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Me3 Gene Detail
Summary
  • Symbol
    Me3
  • Name
    malic enzyme 3, NADP(+)-dependent, mitochondrial
  • Synonyms
    1700020C08Rik, B230207H15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916679
    NCBI Gene: 109264
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:89281492-89503423 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 50.27 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    5835 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916679
 protein coding gene Chr7:89281492-89503567 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032498
 protein coding gene Chr7:92038857-92243195 (+)
A/J MGP_AJ_G0032472
 protein coding gene Chr7:89839331-90035558 (+)
AKR/J MGP_AKRJ_G0032408
 protein coding gene Chr7:91917413-92120464 (+)
BALB/cJ MGP_BALBcJ_G0032483
 protein coding gene Chr7:89486199-89677483 (+)
C3H/HeJ MGP_C3HHeJ_G0032198
 protein coding gene Chr7:92328229-92524902 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032981
 protein coding gene Chr7:95608933-95835367 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029976
 protein coding gene Chr7:92752298-92934883 (+)
CAST/EiJ MGP_CASTEiJ_G0031525
 protein coding gene Chr7:83756513-83962206 (+)
CBA/J MGP_CBAJ_G0032165
 protein coding gene Chr7:98800580-99025485 (+)
DBA/2J MGP_DBA2J_G0032317
 protein coding gene Chr7:88272279-88464252 (+)
FVB/NJ MGP_FVBNJ_G0032273
 protein coding gene Chr7:88145304-88336696 (+)
LP/J MGP_LPJ_G0032406
 protein coding gene Chr7:93273247-93489514 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032307
 protein coding gene Chr7:99840665-100048292 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033003
 protein coding gene Chr7:91218086-91420426 (+)
PWK/PhJ MGP_PWKPhJ_G0031243
 protein coding gene Chr7:81285246-81489166 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031086
 protein coding gene Chr7:78541263-78740986 (+)
WSB/EiJ MGP_WSBEiJ_G0031642
 protein coding gene Chr7:91839724-92070158 (+)



Homology
more
  • Human Ortholog
    ME3, malic enzyme 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ME3, malic enzyme 3
  • Synonyms
    NADP-ME
  • Links
    NCBI Gene ID: 10873
    neXtProt AC: NX_Q16798
    UniProt: Q16798

  • Chr Location
    11q14.2; chr11:86434930-86672636 (-)  GRCh38
  • MGI Vertebrate Homology
    Me3 stringent orthology
    1 human;1 mouse;1 rat;1 zebrafish
  • HCOP
    vertebrate homology predictions: ME3
  • Protein SuperFamily
    ME
  • Gene Tree
    Me3
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    883
  • Tissues
    168
  • cDNA Data
    13
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 109264 NCBI Gene Model | MGI Sequence Detail 221932 C57BL/6J ±  kb
transcript NM_181407 RefSeq | MGI Sequence Detail 4599 C57BL/6  
polypeptide Q8BMF3 UniProt | EBI | MGI Sequence Detail 604 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    cDNA 13

    Microarray probesets 3
Other
Accession IDs
less
MGI:1924706
References
more
  • Summaries
    All 60
    Developmental Gene Expression 4
    Gene Ontology 10
    Phenotypes 30
  • Earliest
    J:330408 Sauer LA, et al., Identification and properties of the nicotinamide adenine dinucleotide (phosphate)+-dependent malic enzyme in mouse ascites tumor mitochondria. Cancer Res. 1978 Jun;38(6):1751-6
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory