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Mtfp1 Gene Detail
Summary
  • Symbol
    Mtfp1
  • Name
    mitochondrial fission process 1
  • Synonyms
    1700020C11Rik, 2610507A21Rik, Mtp18
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916686
    NCBI Gene: 67900
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:4041481-4045431 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 2.87 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    132 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916686
 protein coding gene Chr11:4041480-4045445 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017973
 protein coding gene Chr11:1014767-1018743 (-)
A/J MGP_AJ_G0017946
 protein coding gene Chr11:1034744-1038707 (-)
AKR/J MGP_AKRJ_G0017910
 protein coding gene Chr11:1083864-1087826 (-)
BALB/cJ MGP_BALBcJ_G0017914
 protein coding gene Chr11:1002497-1006462 (-)
C3H/HeJ MGP_C3HHeJ_G0017727
 protein coding gene Chr11:982132-986109 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018367
 protein coding gene Chr11:1099097-1106183 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016025
 protein coding gene Chr11:912860-918191 (-)
CAST/EiJ MGP_CASTEiJ_G0017289
 protein coding gene Chr11:946174-950125 (-)
CBA/J MGP_CBAJ_G0017702
 protein coding gene Chr11:1325788-1329755 (-)
DBA/2J MGP_DBA2J_G0017813
 protein coding gene Chr11:935174-939136 (-)
FVB/NJ MGP_FVBNJ_G0017804
 protein coding gene Chr11:967393-972447 (-)
LP/J MGP_LPJ_G0017883
 protein coding gene Chr11:1127140-1132064 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017830
 protein coding gene Chr11:1011501-1015464 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018406
 protein coding gene Chr11:1084357-1088323 (-)
PWK/PhJ MGP_PWKPhJ_G0017070
 protein coding gene Chr11:934672-939446 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016866
 protein coding gene Chr11:1035662-1039602 (-)
WSB/EiJ MGP_WSBEiJ_G0017343
 protein coding gene Chr11:959676-963639 (-)



Homology
more
  • Human Ortholog
    MTFP1, mitochondrial fission process 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MTFP1, mitochondrial fission process 1
  • Synonyms
    HSPC242, MTP18
  • Links
    NCBI Gene ID: 51537
    neXtProt AC: NX_Q9UDX5
    UniProt: Q9UDX5

  • Chr Location
    22q12.2; chr22:30425623-30429054 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    7
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    707
  • Tissues
    1
  • cDNA Data
    36
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67900 NCBI Gene Model | MGI Sequence Detail 3951 C57BL/6J ±  kb
    transcript NM_026443 RefSeq | MGI Sequence Detail 1396 C57BL/6  
    polypeptide Q9CRB8 UniProt | EBI | MGI Sequence Detail 166 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 36
      cDNA 36

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1915150, MGI:2144449
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 9
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:344739 Patitucci C, et al., Mtfp1 ablation enhances mitochondrial respiration and protects against hepatic steatosis. Nat Commun. 2023 Dec 20;14(1):8474
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory