Dennd6b MGI Mouse Gene Detail - MGI:1916690

Symbol

Dennd6b
Name

DENN domain containing 6B
Synonyms

1700027J05Rik, Fam116b

Feature Type

protein coding gene
IDs

MGI:1916690
NCBI Gene: 69440
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr15:89066416-89080699 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 44.70 cM
Mapping Data

2 experiments

SNPs within 2kb

341 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916690	protein coding gene	Chr15:89066416-89080793 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022222	protein coding gene	Chr15:90358085-90372528 (-)
A/J	MGP_AJ_G0022181	protein coding gene	Chr15:86906843-86921098 (-)
AKR/J	MGP_AKRJ_G0022156	protein coding gene	Chr15:89472017-89486272 (-)
BALB/cJ	MGP_BALBcJ_G0022187	protein coding gene	Chr15:87007972-87022227 (-)
C3H/HeJ	MGP_C3HHeJ_G0021957	protein coding gene	Chr15:89460978-89475239 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022632	protein coding gene	Chr15:93638445-93654665 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020157	protein coding gene	Chr15:83129260-83144581 (-)
CAST/EiJ	MGP_CASTEiJ_G0021479	protein coding gene	Chr15:90247147-90261420 (-)
CBA/J	MGP_CBAJ_G0021924	protein coding gene	Chr15:96805927-96820182 (-)
DBA/2J	MGP_DBA2J_G0022051	protein coding gene	Chr15:86358374-86373263 (-)
FVB/NJ	MGP_FVBNJ_G0022030	protein coding gene	Chr15:85423945-85437750 (-)
LP/J	MGP_LPJ_G0022122	protein coding gene	Chr15:90515332-90529917 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022050	protein coding gene	Chr15:101227083-101242632 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022647	protein coding gene	Chr15:89508656-89524107 (-)
PWK/PhJ	MGP_PWKPhJ_G0021220	protein coding gene	Chr15:86403084-86417760 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021054	protein coding gene	Chr15:89241058-89257319 (-)
WSB/EiJ	MGP_WSBEiJ_G0021528	protein coding gene	Chr15:89996787-90011019 (-)

Human Ortholog

DENND6B, DENN domain containing 6B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DENND6B, DENN domain containing 6B
Synonyms

AFI1B, FAM116B
Links

HGNC:32690

NCBI Gene ID: 414918

neXtProt AC: NX_Q8NEG7

UniProt: Q8NEG7
Chr Location

22q13.33; chr22:50309030-50327012 (-) GRCh38

MGI Vertebrate Homology

Dennd6b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DENND6B
Gene Tree

Dennd6b

less

References

1 with disease annotations

less

Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
28 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

1
Radiation induced

2
Targeted

2
Genomic Mutations

3 involving Dennd6b
Incidental Mutations

APF
Find Mice (IMSR)

36 strains or lines available

less

All GO Annotations

4
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

812
Tissues

32
cDNA Data

8
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dennd6b

ZFIN dennd6b

less

All Sequences

59
RefSeq

8
UniProt

2
CCDS

CCDS57000.1

Ensembl

ENSMUSG00000015377 (Evidence)
NCBI Gene

69440

			Length	Strain/Species	Flank
genomic	ENSMUSG00000015377	Ensembl Gene Model \| MGI Sequence Detail	14284	C57BL/6J	± kb
transcript	ENSMUST00000078953	Ensembl \| MGI Sequence Detail	4585	Not Applicable
polypeptide	ENSMUSP00000077978	Ensembl \| MGI Sequence Detail	585	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000031821 protein FAM116B

(term hierarchy)
InterPro Domains

IPR001194 cDENN domain

IPR024224 DENND6

IPR037516 Tripartite DENN domain

less

All nucleic 8

cDNA 8

Microarray probesets 7

less

MGI:2145991

Summaries

All 51

Developmental Gene Expression 1

Diseases 1

Gene Ontology 4

Phenotypes 28
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Dennd6b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr135861	Chr15:89080660-89080681 (-)	28 bp
Tssr135860	Chr15:89080646-89080657 (-)	47 bp
Tssr135859	Chr15:89080617-89080633 (-)	74 bp
Tssr135858	Chr15:89074718-89074766 (-)	5,957 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24