Jsrp1 MGI Mouse Gene Detail - MGI:1916700 - junctional sarcoplasmic reticulum protein 1

Symbol

Jsrp1
Name

junctional sarcoplasmic reticulum protein 1
Synonyms

2300003C06Rik, 2310032K21Rik, JP-45, JP45

Feature Type

protein coding gene
IDs

MGI:1916700
NCBI Gene: 71912
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr10:80644330-80649332 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM, cytoband C1
Mapping Data

2 experiments

SNPs within 2kb

157 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916700	protein coding gene	Chr10:80644330-80649359 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017521	protein coding gene	Chr10:81461482-81473881 (-)
A/J	MGP_AJ_G0017499	protein coding gene	Chr10:78600143-78605145 (-)
AKR/J	MGP_AKRJ_G0017460	protein coding gene	Chr10:80754187-80759182 (-)
BALB/cJ	MGP_BALBcJ_G0017461	protein coding gene	Chr10:78813995-78818997 (-)
C3H/HeJ	MGP_C3HHeJ_G0017284	protein coding gene	Chr10:80840439-80845437 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017915	protein coding gene	Chr10:84265132-84270161 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015604	protein coding gene	Chr10:74809387-74814657 (-)
CAST/EiJ	MGP_CASTEiJ_G0016851	protein coding gene	Chr10:81068699-81073735 (-)
CBA/J	MGP_CBAJ_G0017256	protein coding gene	Chr10:87536617-87541617 (-)
DBA/2J	MGP_DBA2J_G0017362	protein coding gene	Chr10:77798981-77803981 (-)
FVB/NJ	MGP_FVBNJ_G0017356	protein coding gene	Chr10:77030658-77035670 (-)
LP/J	MGP_LPJ_G0017433	protein coding gene	Chr10:81926297-81931299 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017382	protein coding gene	Chr10:89451563-89456535 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017956	protein coding gene	Chr10:80747972-80754540 (-)
PWK/PhJ	MGP_PWKPhJ_G0016632	protein coding gene	Chr10:77687784-77693030 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016422	protein coding gene	Chr10:79694996-79700128 (-)
WSB/EiJ	MGP_WSBEiJ_G0016911	protein coding gene	Chr10:80785345-80790335 (-)

Human Ortholog

JSRP1, junctional sarcoplasmic reticulum protein 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

JSRP1, junctional sarcoplasmic reticulum protein 1
Synonyms

JP-45, JP45
Links

HGNC:24963

NCBI Gene ID: 126306

neXtProt AC: NX_Q96MG2

UniProt: Q96MG2
Chr Location

19p13.3; chr19:2252252-2269759 (-) GRCh38

MGI Vertebrate Homology

Jsrp1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: JSRP1
Gene Tree

Jsrp1

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

1
Targeted

2
Genomic Mutations

1 involving Jsrp1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

13 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit muscle weakness, abnormal voluntary movement and abnormal muscle physiology.

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All GO Annotations

10
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

725
Tissues

9
cDNA Data

12
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase jsrp1

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All Sequences

40
RefSeq

4
UniProt

4
CCDS

CCDS24034.2

Ensembl

ENSMUSG00000020216 (Evidence)
NCBI Gene

71912

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020216	Ensembl Gene Model \| MGI Sequence Detail	5003	C57BL/6J	± kb
transcript	ENSMUST00000181039	Ensembl \| MGI Sequence Detail	1108	Not Applicable
polypeptide	ENSMUSP00000137666	Ensembl \| MGI Sequence Detail	332	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000009228 junctional sarcoplasmic reticulum protein 1

(term hierarchy)
InterPro Domains

IPR026178 Junctional sarcoplasmic reticulum protein 1

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All nucleic 12

cDNA 12

Microarray probesets 2

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MGI:1919162

Summaries

All 37

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 14
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:235459 Mosca B, et al., Role of the JP45-Calsequestrin Complex on Calcium Entry in Slow Twitch Skeletal Muscles. J Biol Chem. 2016 Jul 8;291(28):14555-65

TSS for Jsrp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr98518	Chr10:80649320-80649367 (-)	-12 bp
Tssr98517	Chr10:80648397-80648418 (-)	924 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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