Frey1 MGI Mouse Gene Detail - MGI:1916742 - Frey regulator of sperm-oocyte fusion 1

Symbol

Frey1
Name

Frey regulator of sperm-oocyte fusion 1
Synonyms

1700021K07Rik, 1700029I15Rik

Feature Type

protein coding gene
IDs

MGI:1916742
NCBI Gene: 75641
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr2:92213263-92213948 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 50.99 cM
Mapping Data

1 experiment

SNPs within 2kb

67 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916742	protein coding gene	Chr2:92212883-92216053 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026166	protein coding gene	Chr2:93813202-93816372 (+)
A/J	MGP_AJ_G0026127	protein coding gene	Chr2:90016167-90019321 (+)
AKR/J	MGP_AKRJ_G0026108	protein coding gene	Chr2:92505444-92508612 (+)
BALB/cJ	MGP_BALBcJ_G0026136	protein coding gene	Chr2:90200537-90203707 (+)
C3H/HeJ	MGP_C3HHeJ_G0025887	protein coding gene	Chr2:92811382-92814550 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026587	protein coding gene	Chr2:97028484-97031654 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023978	protein coding gene	Chr2:86508397-86511539 (+)
CAST/EiJ	MGP_CASTEiJ_G0025352	protein coding gene	Chr2:93357549-93360695 (+)
CBA/J	MGP_CBAJ_G0025865	protein coding gene	Chr2:100414467-100417637 (+)
DBA/2J	MGP_DBA2J_G0026001	protein coding gene	Chr2:89609229-89612399 (+)
FVB/NJ	MGP_FVBNJ_G0025964	protein coding gene	Chr2:88720035-88723203 (+)
LP/J	MGP_LPJ_G0026105	protein coding gene	Chr2:94009265-94012435 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025990	protein coding gene	Chr2:103372916-103376086 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026641	protein coding gene	Chr2:92589000-92592170 (+)
PWK/PhJ	MGP_PWKPhJ_G0025087	protein coding gene	Chr2:89354850-89358006 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024888	protein coding gene	Chr2:92159138-92162278 (+)
WSB/EiJ	MGP_WSBEiJ_G0025419	protein coding gene	Chr2:93207048-93210202 (+)

Human Ortholog

FREY1, Frey regulator of sperm-oocyte fusion 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FREY1, Frey regulator of sperm-oocyte fusion 1
Synonyms

C11orf94, Frey
Links

HGNC:37213

NCBI Gene ID: 143678

neXtProt AC: NX_C9JXX5

UniProt: C9JXX5
Chr Location

11p11.2; chr11:45906513-45907272 (-) GRCh38

MGI Vertebrate Homology

Frey1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: FREY1
Gene Tree

Frey1

less

Phenotype Summary

11 phenotypes from 4 alleles in 4 genetic backgrounds
1 phenotype from multigenic genotypes
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

3
Radiation induced

1
Targeted

4
Transgenic

1
Genomic Mutations

4 involving Frey1
Incidental Mutations

APF
Find Mice (IMSR)

8 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mutations in this gene result in male infertility due to failure of sperm-egg fusion.

less

All GO Annotations

17
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

5

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

less

All Sequences

39
RefSeq

2
UniProt

3
CCDS

CCDS16445.1

Ensembl

ENSMUSG00000044916 (Evidence)
NCBI Gene

75641

			Length	Strain/Species	Flank
genomic	75641	NCBI Gene Model \| MGI Sequence Detail	686	C57BL/6J	± kb
transcript	NM_183112	RefSeq \| MGI Sequence Detail	420	C57BL/6
polypeptide	Q8CF31	UniProt \| EBI \| MGI Sequence Detail	99	Not Applicable

less

UniProt

3 Sequences
Protein Ontology

PR:000059732 protein Frey 1

(term hierarchy)
InterPro Domains

IPR031748 Protein Frey

less

All nucleic 5

cDNA 5

Microarray probesets 4

less

MGI:1922891, MGI:7384624

Summaries

All 33

Gene Ontology 4

Phenotypes 15
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:353044 Cai R, et al., Pressure sensing of lysosomes enables control of TFEB responses in macrophages. Nat Cell Biol. 2024 Jul 12;

TSS for Frey1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr18945	Chr2:92213256-92213269 (+)	0 bp
Tssr18946	Chr2:92213277-92213286 (+)	19 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24