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Antxr1 Gene Detail
Summary
  • Symbol
    Antxr1
  • Name
    anthrax toxin receptor 1
  • Synonyms
    2310008J16Rik, 2810405N18Rik, Tem8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916788
    NCBI Gene: 69538
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:87110835-87312757 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 37.94 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5681 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916788
 protein coding gene Chr6:87110835-87312803 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030988
 protein coding gene Chr6:88475129-88684624 (-)
A/J MGP_AJ_G0030954
 protein coding gene Chr6:85055468-85255713 (-)
AKR/J MGP_AKRJ_G0030885
 protein coding gene Chr6:87528897-87726111 (-)
BALB/cJ MGP_BALBcJ_G0030967
 protein coding gene Chr6:85063284-85257336 (-)
C3H/HeJ MGP_C3HHeJ_G0030743
 protein coding gene Chr6:96753571-96959004 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031424
 protein coding gene Chr6:90861004-91065796 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028608
 protein coding gene Chr6:83235283-83450491 (-)
CAST/EiJ MGP_CASTEiJ_G0030076
 protein coding gene Chr6:87584566-87795402 (-)
CBA/J MGP_CBAJ_G0030651
 protein coding gene Chr6:94417608-94613674 (-)
DBA/2J MGP_DBA2J_G0030807
 protein coding gene Chr6:84361835-84561379 (-)
FVB/NJ MGP_FVBNJ_G0030760
 protein coding gene Chr6:83544552-83742305 (-)
LP/J MGP_LPJ_G0030884
 protein coding gene Chr6:88492684-88697702 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030793
 protein coding gene Chr6:98523520-98728043 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031451
 protein coding gene Chr6:87363228-87568496 (-)
PWK/PhJ MGP_PWKPhJ_G0029791
 protein coding gene Chr6:83323803-83523809 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029619
 protein coding gene Chr6:86183658-86383359 (-)
WSB/EiJ MGP_WSBEiJ_G0030157
 protein coding gene Chr6:87828886-88023558 (-)



Homology
more
  • Human Ortholog
    ANTXR1, ANTXR cell adhesion molecule 1
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ANTXR1, ANTXR cell adhesion molecule 1
  • Synonyms
    ATR, GAPO, TEM8
  • Links
    NCBI Gene ID: 84168
    neXtProt AC: NX_Q9H6X2
    UniProt: Q9H6X2

  • Chr Location
    2p13.3; chr2:69013144-69249327 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human ANTXR1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display female infertility and malocclusion of the incisors. Mice homozygous for a different knock-out allele exhibit malocclusion of incisors and increased extracellular matrix deposition in several organs, includingthe ovaries and uterus, but normal fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    737
  • Tissues
    28
  • cDNA Data
    9
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 69538 NCBI Gene Model | MGI Sequence Detail 201923 C57BL/6J ±  kb
    transcript NM_054041 RefSeq | MGI Sequence Detail 5280 C57BL/6  
    polypeptide Q9CZ52 UniProt | EBI | MGI Sequence Detail 562 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000004068 anthrax toxin receptor 1
      (term hierarchy)
    • InterPro Domains
      IPR008399 Anthrax toxin receptor, C-terminal
      IPR008400 Anthrax toxin receptor, extracellular domain
      IPR036465 von Willebrand factor A-like domain superfamily
      IPR002035 von Willebrand factor, type A
    • GlyGen
      Q9CZ52 3 sites, 2 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 12
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1919432
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 6
      Gene Ontology 8
      Phenotypes 23
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:331389 Hsu KS, et al., Cancer cell survival depends on collagen uptake into tumor-associated stroma. Nat Commun. 2022 Nov 18;13(1):7078
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory