Mtfmt MGI Mouse Gene Detail - MGI:1916856 - mitochondrial methionyl-tRNA formyltransferase

Symbol

Mtfmt
Name

mitochondrial methionyl-tRNA formyltransferase
Synonyms

2310020P08Rik

Feature Type

protein coding gene
IDs

MGI:1916856
NCBI Gene: 69606
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr9:65343064-65360336 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 35.31 cM, cytoband D
Mapping Data

2 experiments

SNPs within 2kb

619 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916856	protein coding gene	Chr9:65343064-65360336 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034959	protein coding gene	Chr9:65169180-65188416 (+)
A/J	MGP_AJ_G0034939	protein coding gene	Chr9:62972535-62990648 (+)
AKR/J	MGP_AKRJ_G0034869	protein coding gene	Chr9:64465306-64482580 (+)
BALB/cJ	MGP_BALBcJ_G0034932	protein coding gene	Chr9:62696104-62713565 (+)
C3H/HeJ	MGP_C3HHeJ_G0034642	protein coding gene	Chr9:64993228-65011028 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035451	protein coding gene	Chr9:66951228-66970564 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032362	protein coding gene	Chr9:62621072-62639731 (+)
CAST/EiJ	MGP_CASTEiJ_G0033963	protein coding gene	Chr9:65176996-65194087 (+)
CBA/J	MGP_CBAJ_G0034613	protein coding gene	Chr9:69294300-69314457 (+)
DBA/2J	MGP_DBA2J_G0034772	protein coding gene	Chr9:62742728-62760278 (+)
FVB/NJ	MGP_FVBNJ_G0034714	protein coding gene	Chr9:62067094-62084856 (+)
LP/J	MGP_LPJ_G0034855	protein coding gene	Chr9:65448229-65465301 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034756	protein coding gene	Chr9:70508344-70530862 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035473	protein coding gene	Chr9:64563015-64581279 (+)
PWK/PhJ	MGP_PWKPhJ_G0033667	protein coding gene	Chr9:62947334-62965586 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033501	protein coding gene	Chr9:64847358-64867943 (+)
WSB/EiJ	MGP_WSBEiJ_G0034076	protein coding gene	Chr9:64468671-64485891 (+)

Human Ortholog

MTFMT, mitochondrial methionyl-tRNA formyltransferase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MTFMT, mitochondrial methionyl-tRNA formyltransferase
Synonyms

COXPD15, FMT1, MC1DN27
Links

HGNC:29666

NCBI Gene ID: 123263

neXtProt AC: NX_Q96DP5

UniProt: Q96DP5
Chr Location

15q22.31; chr15:65001512-65029639 (-) GRCh38

MGI Vertebrate Homology

Mtfmt stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MTFMT
Gene Tree

Mtfmt

Diseases

2 with human MTFMT associations

				Human Disease	Mouse Models
				combined oxidative phosphorylation deficiency 15 IDs combined oxidative phosphorylation deficiency 15 DOID:0111491 OMIM:614947 ORDO:319524
				nuclear type mitochondrial complex I deficiency 27 IDs nuclear type mitochondrial complex I deficiency 27 DOID:0112090 OMIM:618248

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

18 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

2
Targeted

3
Genomic Mutations

1 involving Mtfmt
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele display embryonic lethality with mitochondrial abnormalities. Male mice heterozygous for a null mutation display resistance to high-fat diet induced metabolic changes.

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All GO Annotations

9
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

800
Tissues

94
cDNA Data

31
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mtfmt

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All Sequences

37
RefSeq

2
UniProt

3
CCDS

CCDS23292.1

Ensembl

ENSMUSG00000059183 (Evidence)
NCBI Gene

69606

			Length	Strain/Species	Flank
genomic	69606	NCBI Gene Model \| MGI Sequence Detail	17273	C57BL/6J	± kb
transcript	NM_027134	RefSeq \| MGI Sequence Detail	2042	C57BL/6
polypeptide	Q9D799	UniProt \| EBI \| MGI Sequence Detail	386	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000010719 methionyl-tRNA formyltransferase, mitochondrial

(term hierarchy)
EC

2.1.2.9
InterPro Domains

IPR005793 Formyl transferase, C-terminal

IPR002376 Formyl transferase, N-terminal

IPR036477 Formyl transferase, N-terminal domain superfamily

IPR005794 Methionyl-tRNA formyltransferase

IPR041711 Methionyl-tRNA formyltransferase, N-terminal domain

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All nucleic 31

cDNA 31

Microarray probesets 4

Summaries

All 41

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 13
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Mtfmt:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr85701	Chr9:65343048-65343075 (+)	-2 bp
Tssr85702	Chr9:65343079-65343127 (+)	39 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24