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Kansl2 Gene Detail
Summary
  • Symbol
    Kansl2
  • Name
    KAT8 regulatory NSL complex subunit 2
  • Synonyms
    2310037I24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916862
    NCBI Gene: 69612
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:98415539-98432145 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 54.52 cM, cytoband F2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    506 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916862
 protein coding gene Chr15:98415539-98432649 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022300
 protein coding gene Chr15:100249806-100265528 (-)
A/J MGP_AJ_G0022258
 protein coding gene Chr15:96295627-96313000 (-)
AKR/J MGP_AKRJ_G0022233
 protein coding gene Chr15:99238080-99263122 (-)
BALB/cJ MGP_BALBcJ_G0022265
 protein coding gene Chr15:96492922-96509435 (-)
C3H/HeJ MGP_C3HHeJ_G0022033
 protein coding gene Chr15:99294396-99313588 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022710
 protein coding gene Chr15:103961747-103977949 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020235
 protein coding gene Chr15:92212117-92227552 (-)
CAST/EiJ MGP_CASTEiJ_G0021556
 protein coding gene Chr15:100157209-100172693 (-)
CBA/J MGP_CBAJ_G0022002
 protein coding gene Chr15:107490618-107511323 (-)
DBA/2J MGP_DBA2J_G0022128
 protein coding gene Chr15:95743574-95758951 (-)
FVB/NJ MGP_FVBNJ_G0022108
 protein coding gene Chr15:94714674-94732311 (-)
LP/J MGP_LPJ_G0022200
 protein coding gene Chr15:100405541-100420918 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022128
 protein coding gene Chr15:111516677-111532303 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022725
 protein coding gene Chr15:99341271-99357273 (-)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0021132
 protein coding gene Chr15:99178418-99197218 (-)
WSB/EiJ MGP_WSBEiJ_G0021606
 protein coding gene Chr15:99872318-99887785 (-)



Homology
more
  • Human Ortholog
    KANSL2, KAT8 regulatory NSL complex subunit 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KANSL2, KAT8 regulatory NSL complex subunit 2
  • Synonyms
    C12orf41, NSL2
  • Links
    NCBI Gene ID: 54934
    neXtProt AC: NX_Q9H9L4
    UniProt: Q9H9L4

  • Chr Location
    12q13.11; chr12:48653211-48682238 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a floxed allele deleted in the brain exhibit prenatal lethality, intraventricular hemorrhage, and enlarged lateral ventricles.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    744
  • Tissues
    8
  • cDNA Data
    20
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022992 Ensembl Gene Model | MGI Sequence Detail 16607 C57BL/6J ±  kb
    transcript ENSMUST00000230542 Ensembl | MGI Sequence Detail 3596 Not Applicable  
    polypeptide ENSMUSP00000155089 Ensembl | MGI Sequence Detail 486 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 21
      Primer pair 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 8
      Phenotypes 29
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:347290 Guhathakurta S, et al., COX17 acetylation via MOF-KANSL complex promotes mitochondrial integrity and function. Nat Metab. 2023 Nov;5(11):1931-1952
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory