Col22a1 MGI Mouse Gene Detail - MGI:1916950 - collagen, type XXII, alpha 1

Symbol

Col22a1
Name

collagen, type XXII, alpha 1
Synonyms

2310067L16Rik, C80743

Feature Type

protein coding gene
IDs

MGI:1916950
NCBI Gene: 69700
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr15:71667644-71906076 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 32.31 cM
Mapping Data

2 experiments

SNPs within 2kb

8381 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916950	protein coding gene	Chr15:71667644-71906087 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021915	protein coding gene	Chr15:71460343-71707404 (-)
A/J	MGP_AJ_G0021874	protein coding gene	Chr15:68894197-69146467 (-)
AKR/J	MGP_AKRJ_G0021856	protein coding gene	Chr15:70655245-70902457 (-)
BALB/cJ	MGP_BALBcJ_G0021881	protein coding gene	Chr15:68909640-69150686 (-)
C3H/HeJ	MGP_C3HHeJ_G0021654	protein coding gene	Chr15:70800685-71047532 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022320	protein coding gene	Chr15:74215069-74461108 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019857	protein coding gene	Chr15:65377965-65617636 (-)
CAST/EiJ	MGP_CASTEiJ_G0021173	protein coding gene	Chr15:71517307-71772039 (-)
CBA/J	MGP_CBAJ_G0021620	protein coding gene	Chr15:76643155-76904909 (-)
DBA/2J	MGP_DBA2J_G0021745	protein coding gene	Chr15:68510398-68760441 (-)
FVB/NJ	MGP_FVBNJ_G0021727	protein coding gene	Chr15:67526859-67771284 (-)
LP/J	MGP_LPJ_G0021817	protein coding gene	Chr15:71482122-71734274 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021750	protein coding gene	Chr15:82045063-82299077 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022342	protein coding gene	Chr15:71054216-71302958 (-)
PWK/PhJ	MGP_PWKPhJ_G0020914	protein coding gene	Chr15:68586880-68830779 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020755	protein coding gene	Chr15:70881756-71169538 (-)
WSB/EiJ	MGP_WSBEiJ_G0021225	protein coding gene	Chr15:71033897-71286673 (-)

Human Ortholog

COL22A1, collagen type XXII alpha 1 chain

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

COL22A1, collagen type XXII alpha 1 chain
Links

HGNC:22989

NCBI Gene ID: 169044

neXtProt AC: NX_Q8NFW1

UniProt: Q8NFW1
Chr Location

8q24.23-q24.3; chr8:138588235-138914041 (-) GRCh38

MGI Vertebrate Homology

Col22a1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: COL22A1
Gene Tree

Col22a1

Diseases

1 with human COL22A1 associations

				Human Disease	Mouse Models
				intracranial aneurysm IDs intracranial aneurysm DOID:10941 EFO:0003870 MESH:D002532 NCI:C34458 UMLS_CUI:C0007766

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

29 phenotype references

All Mutations and Alleles

11
Chemically induced (other)

3
Endonuclease-mediated

6
Radiation induced

2
Genomic Mutations

5 involving Col22a1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

80 strains or lines available

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All GO Annotations

4
GO References

1

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

766
Tissues

54
cDNA Data

16
Literature Summary

8

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

43
RefSeq

8
UniProt

4
CCDS

CCDS49627.1

Ensembl

ENSMUSG00000079022 (Evidence)
NCBI Gene

69700

			Length	Strain/Species	Flank
genomic	ENSMUSG00000079022	Ensembl Gene Model \| MGI Sequence Detail	238433	C57BL/6J	± kb
transcript	ENSMUST00000159993	Ensembl \| MGI Sequence Detail	8809	Not Applicable
polypeptide	ENSMUSP00000125069	Ensembl \| MGI Sequence Detail	1613	Not Applicable

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UniProt

4 Sequences
InterPro Domains

IPR050938 Collagen and Collagen-like Structural Proteins

IPR050149 Collagen superfamily

IPR008160 Collagen triple helix repeat

IPR013320 Concanavalin A-like lectin/glucanase domain superfamily

IPR048287 Thrombospondin-like, N-terminal domain

IPR036465 von Willebrand factor A-like domain superfamily

IPR002035 von Willebrand factor, type A

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All nucleic 20

cDNA 17

Primer pair 2

Other 1

Microarray probesets 4

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MGI:2146297

Summaries

All 54

Developmental Gene Expression 8

Diseases 1

Gene Ontology 1

Phenotypes 29
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:346064 Leung AOW, et al., Suppression of apoptosis impairs phalangeal joint formation in the pathogenesis of brachydactyly type A1. Nat Commun. 2024 Mar 12;15(1):2229

TSS for Col22a1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr134649	Chr15:71906051-71906073 (-)	14 bp
Tssr134648	Chr15:71826244-71826273 (-)	79,817 bp
Tssr134647	Chr15:71826235-71826242 (-)	79,837 bp
Tssr134646	Chr15:71826217-71826230 (-)	79,852 bp
Tssr134645	Chr15:71826201-71826213 (-)	79,869 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24