Arap1 MGI Mouse Gene Detail - MGI:1916960 - ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1

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Arap1 Gene Detail

Symbol

Arap1
Name

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
Synonyms

2410002L19Rik, Centd2, mKIAA0782

Feature Type

protein coding gene
IDs

MGI:1916960
NCBI Gene: 69710
Alliance

gene page
Transcription Start Sites

27 TSS

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Sequence Map

Chr7:100997296-101061793 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 54.56 cM, cytoband F1
Mapping Data

2 experiments

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SNPs within 2kb

1601 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_1916960	protein coding gene	Chr7:100997274-101061793 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032584	protein coding gene	Chr7:104314457-104384652 (+)
A/J	MGP_AJ_G0032558	protein coding gene	Chr7:101647967-101714060 (+)
AKR/J	MGP_AKRJ_G0032494	protein coding gene	Chr7:104092290-104143762 (+)
BALB/cJ	MGP_BALBcJ_G0032569	protein coding gene	Chr7:101338304-101406854 (+)
C3H/HeJ	MGP_C3HHeJ_G0032284	protein coding gene	Chr7:104484618-104536810 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033067	protein coding gene	Chr7:108248966-108320351 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030061	protein coding gene	Chr7:104021811-104087506 (+)
CAST/EiJ	MGP_CASTEiJ_G0031611	protein coding gene	Chr7:96020683-96089801 (+)
CBA/J	MGP_CBAJ_G0032251	protein coding gene	Chr7:111985638-112057132 (+)
DBA/2J	MGP_DBA2J_G0032402	protein coding gene	Chr7:100016832-100068687 (+)
FVB/NJ	MGP_FVBNJ_G0032359	protein coding gene	Chr7:99774051-99839551 (+)
LP/J	MGP_LPJ_G0032492	protein coding gene	Chr7:105641543-105711607 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032392	protein coding gene	Chr7:113357973-113425950 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033089	protein coding gene	Chr7:103352800-103421337 (+)
PWK/PhJ	MGP_PWKPhJ_G0031329	protein coding gene	Chr7:93121985-93188482 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031172	protein coding gene	Chr7:90649325-90719110 (+)
WSB/EiJ	MGP_WSBEiJ_G0031728	protein coding gene	Chr7:104064557-104133109 (+)

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Human Ortholog

ARAP1, ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ARAP1, ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
Synonyms

CENTD2, cnt-d2
Links

HGNC:16925

NCBI Gene ID: 116985

neXtProt AC: NX_Q96P48

UniProt: Q96P48
Chr Location

11q13.4; chr11:72685069-72793599 (-) GRCh38

MGI Vertebrate Homology

Arap1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ARAP1
Gene Tree

Arap1

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Phenotype Summary

7 phenotypes from 2 alleles in 3 genetic backgrounds
32 phenotype references

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

29
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

19
Radiation induced

1
Targeted

6
Genomic Mutations

2 involving Arap1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

77 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

40
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

898
Tissues

49
cDNA Data

117
Literature Summary

3

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase arap1

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All Sequences

128
RefSeq

35
UniProt

11
CCDS

CCDS21510.1, CCDS40041.1, CCDS40042.1

Ensembl

ENSMUSG00000032812 (Evidence)
NCBI Gene

69710

Representative Sequences				Length	Strain/Species	Flank
	genomic	69710	NCBI Gene Model \| MGI Sequence Detail	64498	C57BL/6J	± kb
	transcript	NM_001407803	RefSeq \| MGI Sequence Detail	5850	C57BL/6
	polypeptide	Q4LDD4	UniProt \| EBI \| MGI Sequence Detail	1452	Not Applicable

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UniProt

11 Sequences
Protein Ontology

PR:000004193 Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1

(term hierarchy)
PDB

5XHZ
InterPro Domains

IPR037858 ARAP, RhoGAP domain

IPR038508 ArfGAP domain superfamily

IPR037278 ARFGAP/RecO-like zinc finger

IPR052227 Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein

IPR001164 Arf GTPase activating protein

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

IPR000159 Ras-associating domain

IPR000198 Rho GTPase-activating protein domain

IPR008936 Rho GTPase activation protein

IPR001660 Sterile alpha motif domain

IPR013761 Sterile alpha motif/pointed domain superfamily

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All nucleic 119

Genomic 2

cDNA 117

Microarray probesets 4

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Summaries

All 64

Developmental Gene Expression 3

Gene Ontology 7

Phenotypes 32
Earliest

J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Arap1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr68221	Chr7:100997268-100997335 (+)	6 bp
Tssr68222	Chr7:100997347-100997356 (+)	56 bp
Tssr68223	Chr7:101010457-101010494 (+)	13,180 bp
Tssr68224	Chr7:101010672-101010714 (+)	13,397 bp
Tssr68225	Chr7:101011174-101011185 (+)	13,884 bp
Tssr68226	Chr7:101011186-101011195 (+)	13,895 bp
Tssr68227	Chr7:101011204-101011251 (+)	13,932 bp
Tssr68228	Chr7:101011261-101011276 (+)	13,973 bp
Tssr68229	Chr7:101012250-101012297 (+)	14,978 bp
Tssr68230	Chr7:101015779-101015800 (+)	18,494 bp
Tssr68231	Chr7:101022406-101022438 (+)	25,126 bp
Tssr68232	Chr7:101022478-101022491 (+)	25,189 bp
Tssr68233	Chr7:101022516-101022548 (+)	25,236 bp
Tssr68234	Chr7:101027317-101027340 (+)	30,033 bp
Tssr68235	Chr7:101027390-101027417 (+)	30,108 bp
Tssr68236	Chr7:101032021-101032047 (+)	34,738 bp
Tssr68237	Chr7:101033154-101033169 (+)	35,866 bp
Tssr68238	Chr7:101033176-101033183 (+)	35,884 bp
Tssr68239	Chr7:101033192-101033207 (+)	35,904 bp
Tssr68240	Chr7:101033218-101033245 (+)	35,936 bp
Tssr68241	Chr7:101033257-101033282 (+)	35,974 bp
Tssr68242	Chr7:101034079-101034094 (+)	36,791 bp
Tssr68243	Chr7:101034095-101034118 (+)	36,811 bp
Tssr68244	Chr7:101034730-101034759 (+)	37,449 bp
Tssr68245	Chr7:101035992-101036007 (+)	38,704 bp
Tssr68246	Chr7:101043568-101043643 (+)	46,310 bp
Tssr68247	Chr7:101055800-101055825 (+)	58,517 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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