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Usp46 Gene Detail
Summary
  • Symbol
    Usp46
  • Name
    ubiquitin specific peptidase 46
  • Synonyms
    1190009E20Rik, 2410018I08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916977
    NCBI Gene: 69727
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:74159387-74229070 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 39.33 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1985 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916977
 protein coding gene Chr5:74159114-74229092 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029630
 protein coding gene Chr5:74033377-74116609 (-)
A/J MGP_AJ_G0029598
 protein coding gene Chr5:71253767-71324992 (-)
AKR/J MGP_AKRJ_G0029546
 protein coding gene Chr5:73563360-73649124 (-)
BALB/cJ MGP_BALBcJ_G0029607
 protein coding gene Chr5:71963640-72034040 (-)
C3H/HeJ MGP_C3HHeJ_G0029330
 protein coding gene Chr5:73958108-74033022 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030061
 protein coding gene Chr5:77064926-77134603 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027301
 protein coding gene Chr5:66922459-66989864 (-)
CAST/EiJ MGP_CASTEiJ_G0028738
 protein coding gene Chr5:73027121-73111187 (-)
CBA/J MGP_CBAJ_G0029299
 protein coding gene Chr5:79584455-79669989 (-)
DBA/2J MGP_DBA2J_G0029444
 protein coding gene Chr5:71323405-71395211 (-)
FVB/NJ MGP_FVBNJ_G0029405
 protein coding gene Chr5:70470527-70544844 (-)
LP/J MGP_LPJ_G0029530
 protein coding gene Chr5:74477629-74557179 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029432
 protein coding gene Chr5:82873541-82947075 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030094
 protein coding gene Chr5:73100289-73181354 (-)
PWK/PhJ MGP_PWKPhJ_G0028461
 protein coding gene Chr5:70296242-70369968 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028296
 protein coding gene Chr5:72455933-72531896 (-)
WSB/EiJ MGP_WSBEiJ_G0028818
 protein coding gene Chr5:73399863-73478004 (-)



Homology
more
  • Human Ortholog
    USP46, ubiquitin specific peptidase 46
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    USP46, ubiquitin specific peptidase 46
  • Links
    NCBI Gene ID: 64854
    neXtProt AC: NX_P62068
    UniProt: P62068

  • Chr Location
    4q12; chr4:52590960-52659301 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    369 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit reduced depression-related behaviors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    709
  • Tissues
    3
  • cDNA Data
    10
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 69727 NCBI Gene Model | MGI Sequence Detail 69684 C57BL/6J ±  kb
transcript NM_177561 RefSeq | MGI Sequence Detail 4535 C57BL/6  
polypeptide P62069 UniProt | EBI | MGI Sequence Detail 366 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000017185 ubiquitin carboxyl-terminal hydrolase 46
    (term hierarchy)
  • EC
    3.4.19.12
  • InterPro Domains
    IPR038765 Papain-like cysteine peptidase superfamily
    IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
    IPR050164 Ubiquitin carboxyl-terminal hydrolases
    IPR018200 Ubiquitin specific protease, conserved site
    IPR028889 Ubiquitin specific protease domain
  • GlyGen
    P62069 1 site, 1 N-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 10
    cDNA 10

    Microarray probesets 5
Other
Accession IDs
less
MGI:1916152, MGI:2140899
References
more
  • Summaries
    All 397
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 9
    Phenotypes 369
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:353367 Taketomi Y, et al., Lipid-orchestrated paracrine circuit coordinates mast cell maturation and anaphylaxis through functional interaction with fibroblasts. Immunity. 2024 Aug 13;57(8):1828-1847.e11
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory