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Card11 Gene Detail
Summary
  • Symbol
    Card11
  • Name
    caspase recruitment domain family, member 11
  • Synonyms
    0610008L17Rik, 2410011D02Rik, BIMP3, CARMA1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916978
    NCBI Gene: 108723
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:140858745-140986337 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 79.42 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    3927 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916978
 protein coding gene Chr5:140858109-140986398 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030308
 protein coding gene Chr5:145997109-146135437 (-)
A/J MGP_AJ_G0030277
 protein coding gene Chr5:139757846-139889240 (-)
AKR/J MGP_AKRJ_G0030209
 protein coding gene Chr5:144116930-144254674 (-)
BALB/cJ MGP_BALBcJ_G0030294
 protein coding gene Chr5:141005230-141135100 (-)
C3H/HeJ MGP_C3HHeJ_G0030005
 protein coding gene Chr5:144930963-145067657 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030739
 protein coding gene Chr5:151394880-151542404 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027957
 protein coding gene Chr5:133587804-133719488 (-)
CAST/EiJ MGP_CASTEiJ_G0029410
 protein coding gene Chr5:144353271-144491708 (-)
CBA/J MGP_CBAJ_G0029975
 protein coding gene Chr5:157574839-157700537 (-)
DBA/2J MGP_DBA2J_G0030125
 protein coding gene Chr5:139566141-139699188 (-)
FVB/NJ MGP_FVBNJ_G0030080
 protein coding gene Chr5:138726192-138855835 (-)
LP/J MGP_LPJ_G0030211
 protein coding gene Chr5:146599903-146739110 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030111
 protein coding gene Chr5:160173242-160309906 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030779
 protein coding gene Chr5:143961738-144093963 (-)
PWK/PhJ MGP_PWKPhJ_G0029125
 protein coding gene Chr5:138592534-138724060 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028961
 protein coding gene Chr5:141666558-141818906 (-)
WSB/EiJ MGP_WSBEiJ_G0029484
 protein coding gene Chr5:144756886-144891160 (-)



Homology
more
  • Human Ortholog
    CARD11, caspase recruitment domain family member 11
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CARD11, caspase recruitment domain family member 11
  • Synonyms
    BENTA, BIMP3, CARMA1, IMD11, IMD11A, PPBL
  • Links
    NCBI Gene ID: 84433
    neXtProt AC: NX_Q9BXL7
    UniProt: Q9BXL7

  • Chr Location
    7p22.2; chr7:2906142-3044228 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human CARD11 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    98 phenotypes from 18 alleles in 17 genetic backgrounds
    1 phenotype from multigenic genotypes
    48 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation exhibit defects in antigen receptor signalling in both T and B lymphocytes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    51
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000036526 Ensembl Gene Model | MGI Sequence Detail 127593 C57BL/6J ±  kb
    transcript ENSMUST00000085786 Ensembl | MGI Sequence Detail 4107 Not Applicable  
    polypeptide ENSMUSP00000082941 Ensembl | MGI Sequence Detail 1154 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      Genomic 2
      cDNA 11
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1915575
    References
    more
    • Summaries
      All 101
      Gene Ontology 11
      Phenotypes 48
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory