Pold4 MGI Mouse Gene Detail - MGI:1916995 - polymerase (DNA-directed), delta 4

Symbol

Pold4
Name

polymerase (DNA-directed), delta 4
Synonyms

2410012M21Rik, DNA polymerase delta smallest subunit p12, p12

Feature Type

protein coding gene
IDs

MGI:1916995
NCBI Gene: 69745
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr19:4281953-4283688 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 3.93 cM
Mapping Data

2 experiments

SNPs within 2kb

101 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916995	protein coding gene	Chr19:4281947-4283688 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024658	protein coding gene	Chr19:1076208-1077940 (+)
A/J	MGP_AJ_G0024624	protein coding gene	Chr19:1034420-1036138 (+)
AKR/J	MGP_AKRJ_G0024597	protein coding gene	Chr19:1062595-1064321 (+)
BALB/cJ	MGP_BALBcJ_G0024624	protein coding gene	Chr19:1024972-1026702 (+)
C3H/HeJ	MGP_C3HHeJ_G0024392	protein coding gene	Chr19:1059413-1061143 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025072	protein coding gene	Chr19:1113034-1114766 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022501	protein coding gene	Chr19:977889-979596 (+)
CAST/EiJ	MGP_CASTEiJ_G0023864	protein coding gene	Chr19:1073283-1075027 (+)
CBA/J	MGP_CBAJ_G0024363	protein coding gene	Chr19:1176875-1178599 (+)
DBA/2J	MGP_DBA2J_G0024491	protein coding gene	Chr19:994931-996655 (+)
FVB/NJ	MGP_FVBNJ_G0024458	protein coding gene	Chr19:1004155-1006729 (+)
LP/J	MGP_LPJ_G0024577	protein coding gene	Chr19:1069389-1071205 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024488	protein coding gene	Chr19:1118195-1119921 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025119	protein coding gene	Chr19:1060213-1061945 (+)
PWK/PhJ	MGP_PWKPhJ_G0023610	protein coding gene	Chr19:1048371-1050091 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023415	protein coding gene	Chr19:1045048-1047614 (+)
WSB/EiJ	MGP_WSBEiJ_G0023926	protein coding gene	Chr19:1050462-1052188 (+)

Human Ortholog

POLD4, DNA polymerase delta 4, accessory subunit

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

POLD4, DNA polymerase delta 4, accessory subunit
Synonyms

p12, POLDS
Links

HGNC:14106

NCBI Gene ID: 57804

neXtProt AC: NX_Q9HCU8

UniProt: Q9HCU8
Chr Location

11q13.2; chr11:67350765-67356972 (-) GRCh38

MGI Vertebrate Homology

Pold4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: POLD4
Gene Tree

Pold4

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Phenotype Summary

5 phenotypes from 2 alleles in 2 genetic backgrounds
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

2
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

10 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit increased lifespan and decreased incidence of liver tumors. Another null allele shows decreased leukocyte numbers and decreased circulating glucose and calcium levels.

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All GO Annotations

12
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

800
Tissues

94
cDNA Data

80
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

44
RefSeq

3
UniProt

4
CCDS

CCDS29424.1

Ensembl

ENSMUSG00000024854 (Evidence)
NCBI Gene

69745

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024854	Ensembl Gene Model \| MGI Sequence Detail	1736	C57BL/6J	± kb
transcript	ENSMUST00000025773	Ensembl \| MGI Sequence Detail	913	Not Applicable
polypeptide	ENSMUSP00000025773	Ensembl \| MGI Sequence Detail	107	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000012966 DNA polymerase delta subunit 4

(term hierarchy)
InterPro Domains

IPR007218 DNA polymerase delta, subunit 4

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All nucleic 80

cDNA 80

Microarray probesets 3

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MGI:2147559, MGI:2147697

Summaries

All 33

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 6
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Pold4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr154305	Chr19:4281964-4281982 (+)	20 bp
Tssr154306	Chr19:4281985-4282013 (+)	46 bp
Tssr154307	Chr19:4282015-4282031 (+)	70 bp
Tssr154308	Chr19:4282043-4282054 (+)	96 bp
Tssr154309	Chr19:4282462-4282479 (+)	518 bp
Tssr154310	Chr19:4282489-4282533 (+)	558 bp
Tssr154311	Chr19:4282837-4282858 (+)	895 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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