Med30 MGI Mouse Gene Detail - MGI:1917040 - mediator complex subunit 30

Symbol

Med30
Name

mediator complex subunit 30
Synonyms

1810038N03Rik, 2510044J04Rik, Thrap6, Trap25

Feature Type

protein coding gene
IDs

MGI:1917040
NCBI Gene: 69790
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr15:52575841-52593827 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 19.95 cM
Mapping Data

1 experiment

SNPs within 2kb

748 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917040	protein coding gene	Chr15:52575804-52593960 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021842	protein coding gene	Chr15:51702752-51729627 (+)
A/J	MGP_AJ_G0021802	protein coding gene	Chr15:49657997-49677984 (+)
AKR/J	MGP_AKRJ_G0021783	protein coding gene	Chr15:51047332-51065163 (+)
BALB/cJ	MGP_BALBcJ_G0021809	protein coding gene	Chr15:49885502-49903276 (+)
C3H/HeJ	MGP_C3HHeJ_G0021583	protein coding gene	Chr15:51155108-51177148 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022248	protein coding gene	Chr15:53740424-53761457 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019785	protein coding gene	Chr15:47021599-47038822 (+)
CAST/EiJ	MGP_CASTEiJ_G0021100	protein coding gene	Chr15:51692655-51712391 (+)
CBA/J	MGP_CBAJ_G0021552	protein coding gene	Chr15:55678637-55701582 (+)
DBA/2J	MGP_DBA2J_G0021676	protein coding gene	Chr15:49503768-49522304 (+)
FVB/NJ	MGP_FVBNJ_G0021654	protein coding gene	Chr15:48705895-48723717 (+)
LP/J	MGP_LPJ_G0021746	protein coding gene	Chr15:51485111-51504506 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021678	protein coding gene	Chr15:60740832-60760517 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022271	protein coding gene	Chr15:51401668-51419617 (+)
PWK/PhJ	MGP_PWKPhJ_G0020845	protein coding gene	Chr15:49605430-49623375 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020682	protein coding gene	Chr15:51131423-51149228 (+)
WSB/EiJ	MGP_WSBEiJ_G0021155	protein coding gene	Chr15:51379017-51399137 (+)

Human Ortholog

MED30, mediator complex subunit 30

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MED30, mediator complex subunit 30
Synonyms

MED30S, THRAP6, TRAP25
Links

HGNC:23032

NCBI Gene ID: 90390

neXtProt AC: NX_Q96HR3

UniProt: Q96HR3
Chr Location

8q24.11; chr8:117520713-117540262 (+) GRCh38

MGI Vertebrate Homology

Med30 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MED30
Gene Tree

Med30

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References

1 with disease annotations

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Phenotype Summary

17 phenotypes from 2 alleles in 2 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (ENU)

1
Chemically induced (other)

2
Gene trapped

2
Radiation induced

1
Targeted

1
Genomic Mutations

3 involving Med30
Incidental Mutations

APF
Find Mice (IMSR)

9 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for an ENU-induced allele exhibit premature death associated with cachexia and a rapidly progressive cardiomyopathy.

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All GO Annotations

34
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

746
Tissues

16
cDNA Data

50
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase med30

ZFIN med30

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All Sequences

33
RefSeq

2
UniProt

1
CCDS

CCDS27465.1

Ensembl

ENSMUSG00000038622 (Evidence)
NCBI Gene

69790

			Length	Strain/Species	Flank
genomic	69790	NCBI Gene Model \| MGI Sequence Detail	17987	C57BL/6J	± kb
transcript	NM_027212	RefSeq \| MGI Sequence Detail	871	C57BL/6
polypeptide	Q9CQI9	UniProt \| EBI \| MGI Sequence Detail	178	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000010302 mediator of RNA polymerase II transcription subunit 30

(term hierarchy)
PDB

6W1S, 8T1I
InterPro Domains

IPR021019 Mediator complex, subunit Med30, metazoa

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All nucleic 52

cDNA 50

Primer pair 2

Microarray probesets 3

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MGI:1917553

Summaries

All 52

Developmental Gene Expression 4

Diseases 1

Gene Ontology 11

Phenotypes 16
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:347774 Kolonay DW, et al., Temporal regulation of the Mediator complex during muscle proliferation, differentiation, regeneration, aging, and disease. Front Cell Dev Biol. 2024;12:1331563

TSS for Med30:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr131255	Chr15:52575775-52575780 (+)	-63 bp
Tssr131256	Chr15:52575783-52575790 (+)	-54 bp
Tssr131257	Chr15:52575797-52575825 (+)	-30 bp
Tssr131258	Chr15:52575830-52575873 (+)	11 bp
Tssr131259	Chr15:52575878-52575887 (+)	42 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24