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Clec4b1 Gene Detail
Summary
  • Symbol
    Clec4b1
  • Name
    C-type lectin domain family 4, member b1
  • Synonyms
    1810046I24Rik, 1810046I24Rik, DCAR, DCARbeta, mDcar2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917060
    NCBI Gene: 69810
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:123026921-123048514 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 58.13 cM, cytoband F2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    596 from dbSNP Build 142
  • Strain Annotations
    13
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917060
 protein coding gene Chr6:123026921-123048514 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031239
 protein coding gene Chr6:126191203-126216708 (+)
A/J MGP_AJ_G0031208
 protein coding gene Chr6:121377799-121398920 (+)
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ MGP_C3HHeJ_G0030937
 protein coding gene Chr6:124713954-124733090 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031677
 protein coding gene Chr6:129502579-129539096 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028834
 protein coding gene Chr6:118038892-118044177 (+)
CAST/EiJ MGP_CASTEiJ_G0030326
 protein coding gene Chr6:124954969-124978180 (+)
CBA/J no annotation
DBA/2J MGP_DBA2J_G0031056
 protein coding gene Chr6:120322222-120345899 (+)
FVB/NJ MGP_FVBNJ_G0031009
 protein coding gene Chr6:119254545-119274707 (+)
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0031044
 protein coding gene Chr6:138526483-138542679 (+)
NZO/HlLtJ no annotation
PWK/PhJ MGP_PWKPhJ_G0030040
 protein coding gene Chr6:119137567-119164361 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029869
 protein coding gene Chr6:122850081-122855363 (+)
WSB/EiJ MGP_WSBEiJ_G0030408
 protein coding gene Chr6:124929624-124951411 (+)



Homology
more
  • Human Ortholog
    CLEC4C, C-type lectin domain family 4 member C
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLEC4C, C-type lectin domain family 4 member C
  • Synonyms
    BDCA-2, BDCA2, CD303, CLECSF11, CLECSF7, DLEC, HECL, PRO34150
  • Links
    NCBI Gene ID: 170482
    neXtProt AC: NX_Q8WTT0
    UniProt: Q8WTT0

  • Chr Location
    12p13.31
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit reduced numbers of monocyte-derived inflammatory cells at mycobacterial infection sites, impaired IFN-gamma production by T cells and increased bacterial load.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    2
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 69810 NCBI Gene Model | MGI Sequence Detail 21594 C57BL/6J ±  kb
transcript NM_001190310 RefSeq | MGI Sequence Detail 784 C57BL/6  
polypeptide NP_001177239 RefSeq | MGI Sequence Detail 209 C57BL/6  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 2
    cDNA 2

    Microarray probesets 2
References
more
  • Summaries
    All 25
    Developmental Gene Expression 1
    Gene Ontology 2
    Phenotypes 7
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:307311 Nagata M, et al., Helicobacter pylori metabolites exacerbate gastritis through C-type lectin receptors. J Exp Med. 2021 Jan 4;218(1)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory