Smim3 Gene Detail

Summary

• Symbol
  Smim3
• Name
  small integral membrane protein 3
• Synonyms
  2010002N04Rik, cI-41, Nid67

• Feature Type
  protein coding gene
• IDs
  MGI:1917088
  NCBI Gene: 106878
• Alliance
  gene page
• Transcription Start Sites
  7 TSS

Location &
Maps

• Sequence Map
  Chr18:60607263-60635055 bp, - strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 18, 34.36 cM
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  369 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917088	protein coding gene	Chr18:60607263-60635059 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024461	protein coding gene	Chr18:60285198-60314633 (-)
A/J	MGP_AJ_G0024428	protein coding gene	Chr18:57705877-57733731 (-)
AKR/J	MGP_AKRJ_G0024398	protein coding gene	Chr18:59298552-59326100 (-)
BALB/cJ	MGP_BALBcJ_G0024427	protein coding gene	Chr18:57841357-57869394 (-)
C3H/HeJ	MGP_C3HHeJ_G0024195	protein coding gene	Chr18:59528694-59559193 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0024874	protein coding gene	Chr18:61942917-61973261 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022305	protein coding gene	Chr18:57261749-57290139 (-)
CAST/EiJ	MGP_CASTEiJ_G0023668	protein coding gene	Chr18:59392037-59420060 (-)
CBA/J	MGP_CBAJ_G0024165	protein coding gene	Chr18:63959468-63987004 (-)
DBA/2J	MGP_DBA2J_G0024295	protein coding gene	Chr18:57387630-57416140 (-)
FVB/NJ	MGP_FVBNJ_G0024261	protein coding gene	Chr18:56784942-56812759 (-)
LP/J	MGP_LPJ_G0024378	protein coding gene	Chr18:60153032-60180988 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024290	protein coding gene	Chr18:65594990-65623678 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024921	protein coding gene	Chr18:59483162-59514227 (-)
PWK/PhJ	MGP_PWKPhJ_G0023411	protein coding gene	Chr18:57608800-57636564 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023217	protein coding gene	Chr18:59722411-59751743 (-)
WSB/EiJ	MGP_WSBEiJ_G0023732	protein coding gene	Chr18:59348378-59377801 (-)

Homology

• Human Ortholog
  SMIM3, small integral membrane protein 3

• Vertebrate Orthologs
  2

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  SMIM3, small integral membrane protein 3
  
• Synonyms
  C5orf62, MST150, NID67
• Links
  HGNC:30248

  NCBI Gene ID: 85027

  neXtProt AC: NX_Q9BZL3

  UniProt: Q9BZL3

  
  
• Chr Location
  5q33.1; chr5:150778757-150796734 (+)  GRCh38

---

• MGI Vertebrate Homology
  Smim3 stringent orthology
  1 human;1 mouse;1 rat
  
• HCOP
  vertebrate homology predictions: SMIM3
• Gene Tree
  Smim3
  

Human Diseases

• Mutations/Alleles
  1 with disease annotations

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  23 phenotypes from multigenic genotypes
  8 phenotype references
  

• All Mutations and Alleles
  18
• Endonuclease-mediated
  2
• Gene trapped
  14
• Targeted
  2
• Find Mice (IMSR)
  9 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  3
• GO References
  3

Expression

• Assay Results
  732
• Tissues
  3
• cDNA Data
  28
• Literature Summary
  1

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase smim3

Sequences &
Gene Models

• All Sequences
  46
• RefSeq
  6
• UniProt
  3
• CCDS
  CCDS37831.1

• Ensembl
  ENSMUSG00000038059 (Evidence)
• NCBI Gene
  106878

Representative Sequences			Length	Strain/Species
genomic	106878	NCBI Gene Model | MGI Sequence Detail	27793	C57BL/6J
transcript	NM_134133	RefSeq | MGI Sequence Detail	2008	C57BL/6
polypeptide	Q99PE5	UniProt | EBI | MGI Sequence Detail	60	Not Applicable

Protein
Information

• UniProt
  3 Sequences
• Protein Ontology
  PR:000060061 small integral membrane protein 3
  (term hierarchy)
• InterPro Domains
  IPR035275 Small integral membrane protein 3

Molecular
Reagents

• All nucleic 28

  cDNA 28

  
  

  Microarray probesets 4

Other
Accession IDs

MGI:1930796, MGI:2147200

References

• Summaries
  All 34

  Developmental Gene Expression 1

  Diseases 1

  Gene Ontology 3

  Phenotypes 8
• Earliest
  J:66308 Takahashi Y, et al., Identification of cAMP analogue inducible genes in RAW264 macrophages. Biochim Biophys Acta. 2000 Jul 24;1492(2-3):385-94
• Latest
  J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

TSS for Smim3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr153447	Chr18:60635536-60635549 (-)	-488 bp
Tssr153446	Chr18:60634820-60634844 (-)	223 bp
Tssr153445	Chr18:60634765-60634817 (-)	264 bp
Tssr153444	Chr18:60634739-60634749 (-)	311 bp
Tssr153443	Chr18:60634703-60634718 (-)	344 bp
Tssr153442	Chr18:60634587-60634692 (-)	415 bp
Tssr153441	Chr18:60632491-60632502 (-)	2,558 bp