Ndufa11 MGI Mouse Gene Detail - MGI:1917125 - NADH:ubiquinone oxidoreductase subunit A11

Symbol

Ndufa11
Name

NADH:ubiquinone oxidoreductase subunit A11
Synonyms

11, 14.7kDa, 2010012C24Rik, B14.7

Feature Type

protein coding gene
IDs

MGI:1917125
NCBI Gene: 69875
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr17:57024767-57029141 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 29.47 cM, cytoband D
Mapping Data

3 experiments

SNPs within 2kb

178 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917125	protein coding gene	Chr17:57024762-57031248 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023936	protein coding gene	Chr17:58430873-58437359 (+)
A/J	MGP_AJ_G0023894	protein coding gene	Chr17:56833065-56839551 (+)
AKR/J	MGP_AKRJ_G0023863	protein coding gene	Chr17:57538347-57544833 (+)
BALB/cJ	MGP_BALBcJ_G0023895	protein coding gene	Chr17:56651262-56657748 (+)
C3H/HeJ	MGP_C3HHeJ_G0023659	protein coding gene	Chr17:58273046-58279532 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024341	protein coding gene	Chr17:60694614-60701100 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021787	protein coding gene	Chr17:53306439-53313072 (+)
CAST/EiJ	MGP_CASTEiJ_G0023141	protein coding gene	Chr17:58547943-58554430 (+)
CBA/J	MGP_CBAJ_G0023635	protein coding gene	Chr17:63076702-63083188 (+)
DBA/2J	MGP_DBA2J_G0023763	protein coding gene	Chr17:55532702-55539188 (+)
FVB/NJ	MGP_FVBNJ_G0023729	protein coding gene	Chr17:55086634-55093120 (+)
LP/J	MGP_LPJ_G0023845	protein coding gene	Chr17:59121754-59128240 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023757	protein coding gene	Chr17:62553243-62559729 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024385	protein coding gene	Chr17:57906787-57913273 (+)
PWK/PhJ	MGP_PWKPhJ_G0022887	protein coding gene	Chr17:54891673-54899379 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022698	protein coding gene	Chr17:54668940-54675676 (+)
WSB/EiJ	MGP_WSBEiJ_G0023207	protein coding gene	Chr17:58519186-58525674 (+)

Human Ortholog

NDUFA11, NADH:ubiquinone oxidoreductase subunit A11

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NDUFA11, NADH:ubiquinone oxidoreductase subunit A11
Synonyms

B14.7, CI-B14.7, MC1DN14
Links

HGNC:20371

NCBI Gene ID: 126328

neXtProt AC: NX_Q86Y39

UniProt: Q86Y39
Chr Location

19p13.3; chr19:5891229-5904006 (-) GRCh38

MGI Vertebrate Homology

Ndufa11 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NDUFA11
Gene Tree

Ndufa11

Diseases

2 with human NDUFA11 associations

				Human Disease	Mouse Models
				communication disorder IDs communication disorder DOID:2033 ICD10CM:F80.9 MESH:D003147 NCI:C2958 UMLS_CUI:C0009460
				nuclear type mitochondrial complex I deficiency 14 IDs nuclear type mitochondrial complex I deficiency 14 DOID:0112094 OMIM:618236

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

8 phenotypes from 1 allele in 2 genetic backgrounds
1 images
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Endonuclease-mediated

1
Gene trapped

10
Targeted

3
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit decreased embryo size, a rudimentary egg cylinder, failure of primitive streak formation, absent primitive node and head folds, failure to gastrulate, and complete embryonic lethality by E9.5.

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All GO Annotations

11
GO References

7

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

743
Tissues

32
cDNA Data

167
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ndufa11

ZFIN ndufa11

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All Sequences

43
RefSeq

3
UniProt

5
CCDS

CCDS50155.1

Ensembl

ENSMUSG00000002379 (Evidence)
NCBI Gene

69875

			Length	Strain/Species	Flank
genomic	ENSMUSG00000002379	Ensembl Gene Model \| MGI Sequence Detail	4375	C57BL/6J	± kb
transcript	ENSMUST00000002452	Ensembl \| MGI Sequence Detail	545	Not Applicable
polypeptide	ENSMUSP00000002452	Ensembl \| MGI Sequence Detail	143	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000011069 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11

(term hierarchy)
PDB

6G2J, 6G72, 6ZR2, 6ZTQ, 7AK5, 7AK6, 7B93, 7PSA, 8C2S, 8CA3, 8CA5, 8OLT, 8OM1, 8PW5, 8PW6, 8PW7, 8RGP, 8RGQ, 8RGR, 8RGT
InterPro Domains

IPR039205 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11

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All nucleic 167

cDNA 167

Microarray probesets 5

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MGI:2147010

Summaries

All 40

Developmental Gene Expression 2

Gene Ontology 7

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ndufa11:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr145336	Chr17:57024759-57024819 (+)	22 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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