Rab3b MGI Mouse Gene Detail - MGI:1917158 - RAB3B, member RAS oncogene family

Symbol

Rab3b
Name

RAB3B, member RAS oncogene family

Feature Type

protein coding gene
IDs

MGI:1917158
NCBI Gene: 69908
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr4:108736267-108800521 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 50.67 cM, cytoband C7
Mapping Data

2 experiments

SNPs within 2kb

1977 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917158	protein coding gene	Chr4:108736260-108800521 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028565	protein coding gene	Chr4:109634637-109704205 (+)
A/J	MGP_AJ_G0028528	protein coding gene	Chr4:105687737-105750612 (+)
AKR/J	MGP_AKRJ_G0028475	protein coding gene	Chr4:108318421-108384547 (+)
BALB/cJ	MGP_BALBcJ_G0028547	protein coding gene	Chr4:105894998-105957542 (+)
C3H/HeJ	MGP_C3HHeJ_G0028261	protein coding gene	Chr4:109055832-109118926 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028987	protein coding gene	Chr4:113566680-113637845 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026278	protein coding gene	Chr4:100978251-101040898 (+)
CAST/EiJ	MGP_CASTEiJ_G0027697	protein coding gene	Chr4:106912945-106979480 (+)
CBA/J	MGP_CBAJ_G0028230	protein coding gene	Chr4:117294821-117367962 (+)
DBA/2J	MGP_DBA2J_G0028378	protein coding gene	Chr4:105316432-105378620 (+)
FVB/NJ	MGP_FVBNJ_G0028346	protein coding gene	Chr4:104183247-104248839 (+)
LP/J	MGP_LPJ_G0028479	protein coding gene	Chr4:109874411-109944706 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028372	protein coding gene	Chr4:122495680-122566975 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029023	protein coding gene	Chr4:108566428-108630107 (+)
PWK/PhJ	MGP_PWKPhJ_G0027423	protein coding gene	Chr4:103599604-103665226 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027247	protein coding gene	Chr4:105925254-105998228 (+)
WSB/EiJ	MGP_WSBEiJ_G0027778	protein coding gene	Chr4:108738342-108805843 (+)

Human Ortholog

RAB3B, RAB3B, member RAS oncogene family

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RAB3B, RAB3B, member RAS oncogene family
Links

HGNC:9778

NCBI Gene ID: 5865

neXtProt AC: NX_P20337

UniProt: P20337
Chr Location

1p32.3; chr1:51907956-51990700 (-) GRCh38

MGI Vertebrate Homology

Rab3b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RAB3B
Gene Tree

Rab3b

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
13 phenotypes from multigenic genotypes
18 phenotype references

All Mutations and Alleles

15
Chemically induced (other)

2
Endonuclease-mediated

3
Gene trapped

7
Radiation induced

1
Targeted

2
Genomic Mutations

4 involving Rab3b
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

12 strains or lines available

Mice homozygous for a knock-out allele are viable with no apparent decrease in weight or fertility.

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All GO Annotations

33
GO References

14

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

708
Tissues

2
cDNA Data

21
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rab3b

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All Sequences

43
RefSeq

4
UniProt

3
CCDS

CCDS18459.1

Ensembl

ENSMUSG00000003411 (Evidence)
NCBI Gene

69908

			Length	Strain/Species	Flank
genomic	69908	NCBI Gene Model \| MGI Sequence Detail	64255	C57BL/6J	± kb
transcript	NM_023537	RefSeq \| MGI Sequence Detail	3320	C57BL/6
polypeptide	Q9CZT8	UniProt \| EBI \| MGI Sequence Detail	219	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000013618 Ras-related protein Rab-3B

(term hierarchy)
InterPro Domains

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR037872 Rab3

IPR001806 Small GTPase

IPR050305 Small GTPase superfamily, Rab

IPR005225 Small GTP-binding protein domain
GlyGen

Q9CZT8 2 sites, 2 N-linked glycans (2 sites)

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All nucleic 22

cDNA 21

Primer pair 1

Microarray probesets 3

Summaries

All 55

Developmental Gene Expression 3

Gene Ontology 14

Phenotypes 18
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:327415 Jing J, et al., Spatiotemporal single-cell regulatory atlas reveals neural crest lineage diversification and cellular function during tooth morphogenesis. Nat Commun. 2022 Aug 16;13(1):4803

TSS for Rab3b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr38321	Chr4:108736265-108736282 (+)	7 bp
Tssr38322	Chr4:108736289-108736313 (+)	34 bp
Tssr38323	Chr4:108736327-108736338 (+)	66 bp
Tssr38324	Chr4:108736351-108736358 (+)	88 bp
Tssr38325	Chr4:108799547-108799551 (+)	63,282 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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