Galk2 MGI Mouse Gene Detail - MGI:1917226

Symbol

Galk2
Name

galactokinase 2
Synonyms

2810017M24Rik, Gk2

Feature Type

protein coding gene
IDs

MGI:1917226
NCBI Gene: 69976
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr2:125701029-125826218 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 61.76 cM
Mapping Data

2 experiments

SNPs within 2kb

2781 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917226	protein coding gene	Chr2:125701029-125826219 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026435	protein coding gene	Chr2:129071300-129193141 (+)
A/J	MGP_AJ_G0026398	protein coding gene	Chr2:123813720-123937938 (+)
AKR/J	MGP_AKRJ_G0026374	protein coding gene	Chr2:127348603-127481561 (+)
BALB/cJ	MGP_BALBcJ_G0026410	protein coding gene	Chr2:124101940-124224089 (+)
C3H/HeJ	MGP_C3HHeJ_G0026154	protein coding gene	Chr2:127833297-127963681 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026856	protein coding gene	Chr2:133175505-133302741 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024233	protein coding gene	Chr2:118594584-118717740 (+)
CAST/EiJ	MGP_CASTEiJ_G0025615	protein coding gene	Chr2:128087932-128219493 (+)
CBA/J	MGP_CBAJ_G0026134	protein coding gene	Chr2:138001228-138146631 (+)
DBA/2J	MGP_DBA2J_G0026268	protein coding gene	Chr2:123226381-123356388 (+)
FVB/NJ	MGP_FVBNJ_G0026232	protein coding gene	Chr2:121914098-122030690 (+)
LP/J	MGP_LPJ_G0026373	protein coding gene	Chr2:129295657-129421977 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026252	protein coding gene	Chr2:142117015-142243674 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026911	protein coding gene	Chr2:127387808-127511598 (+)
PWK/PhJ	MGP_PWKPhJ_G0025351	protein coding gene	Chr2:122767434-122896450 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025153	protein coding gene	Chr2:126476382-126604119 (+)
WSB/EiJ	MGP_WSBEiJ_G0025689	protein coding gene	Chr2:128293506-128413406 (+)

Human Ortholog

GALK2, galactokinase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GALK2, galactokinase 2
Synonyms

GK2
Links

HGNC:4119

NCBI Gene ID: 2585

neXtProt AC: NX_Q01415

UniProt: Q01415
Chr Location

15q21.1-q21.2; chr15:49155656-49367869 (+) GRCh38

MGI Vertebrate Homology

Galk2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GALK2
Protein SuperFamily

Galactokinase
Gene Tree

Galk2

less

Phenotype Summary

13 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

4
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Galk2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

34 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

less

All GO Annotations

11
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

800
Tissues

94
cDNA Data

72
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase galk2

ZFIN galk2

less

All Sequences

79
RefSeq

16
UniProt

10
CCDS

CCDS16680.1, CCDS71134.1

Ensembl

ENSMUSG00000027207 (Evidence)
NCBI Gene

69976

			Length	Strain/Species	Flank
genomic	69976	NCBI Gene Model \| MGI Sequence Detail	125190	C57BL/6J	± kb
transcript	NM_175154	RefSeq \| MGI Sequence Detail	2629	C57BL/6
polypeptide	Q68FH4	UniProt \| EBI \| MGI Sequence Detail	458	Not Applicable

less

UniProt

10 Sequences
Protein Ontology

PR:000007814 N-acetylgalactosamine kinase

(term hierarchy)
EC

2.7.1.157
InterPro Domains

IPR000705 Galactokinase

IPR019741 Galactokinase, conserved site

IPR019539 Galactokinase, N-terminal domain

IPR006203 GHMP kinase, ATP-binding, conserved site

IPR013750 GHMP kinase, C-terminal domain

IPR036554 GHMP kinase, C-terminal domain superfamily

IPR006204 GHMP kinase N-terminal domain

IPR006206 Mevalonate/galactokinase

IPR020568 Ribosomal protein uS5 domain 2-type superfamily

IPR014721 Small ribosomal subunit protein uS5 domain 2-type fold, subgroup

less

All nucleic 73

cDNA 72

Primer pair 1

Microarray probesets 3

less

MGI:2138914

Summaries

All 42

Developmental Gene Expression 2

Gene Ontology 7

Phenotypes 12
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Galk2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr19907	Chr2:125701083-125701145 (+)	85 bp
Tssr19908	Chr2:125708144-125708202 (+)	7,144 bp
Tssr19909	Chr2:125708203-125708225 (+)	7,185 bp
Tssr19910	Chr2:125708239-125708250 (+)	7,216 bp
Tssr19911	Chr2:125735255-125735262 (+)	34,230 bp
Tssr19912	Chr2:125735265-125735288 (+)	34,248 bp
Tssr19913	Chr2:125735297-125735308 (+)	34,274 bp
Tssr19914	Chr2:125751045-125751050 (+)	50,019 bp
Tssr19915	Chr2:125754589-125754600 (+)	53,566 bp
Tssr19916	Chr2:125783674-125783682 (+)	82,649 bp
Tssr19917	Chr2:125789771-125789774 (+)	88,744 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24