Ddi2 MGI Mouse Gene Detail - MGI:1917244 - DNA-damage inducible protein 2

Symbol

Ddi2
Name

DNA-damage inducible protein 2
Synonyms

1110056G13Rik, 1700027M01Rik, 9130022E05Rik

Feature Type

protein coding gene
IDs

MGI:1917244
NCBI Gene: 68817
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr4:141410874-141450730 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 74.69 cM
Mapping Data

2 experiments

SNPs within 2kb

1067 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917244	protein coding gene	Chr4:141404860-141450730 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0029054	protein coding gene	Chr4:144767619-144814889 (-)
A/J	MGP_AJ_G0029014	protein coding gene	Chr4:138454449-138501093 (-)
AKR/J	MGP_AKRJ_G0028966	protein coding gene	Chr4:142480305-142534238 (-)
BALB/cJ	MGP_BALBcJ_G0029038	protein coding gene	Chr4:139152338-139199096 (-)
C3H/HeJ	MGP_C3HHeJ_G0028752	protein coding gene	Chr4:142843330-142892382 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0029479	protein coding gene	Chr4:149807421-149854250 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026750	protein coding gene	Chr4:131369324-131414002 (-)
CAST/EiJ	MGP_CASTEiJ_G0028184	protein coding gene	Chr4:141112861-141158624 (-)
CBA/J	MGP_CBAJ_G0028716	protein coding gene	Chr4:154222137-154275372 (-)
DBA/2J	MGP_DBA2J_G0028866	protein coding gene	Chr4:138850304-138897022 (-)
FVB/NJ	MGP_FVBNJ_G0028833	protein coding gene	Chr4:137971849-138017794 (-)
LP/J	MGP_LPJ_G0028965	protein coding gene	Chr4:144785397-144830984 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028859	protein coding gene	Chr4:157959368-158006415 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029517	protein coding gene	Chr4:142996134-143044080 (-)
PWK/PhJ	MGP_PWKPhJ_G0027905	protein coding gene	Chr4:135744965-135791780 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0027729	protein coding gene	Chr4:138807039-138853304 (-)
WSB/EiJ	MGP_WSBEiJ_G0028262	protein coding gene	Chr4:143267600-143313522 (-)

Human Ortholog

DDI2, DNA damage inducible 1 homolog 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DDI2, DNA damage inducible 1 homolog 2
Links

HGNC:24578

NCBI Gene ID: 84301

neXtProt AC: NX_Q5TDH0

UniProt: Q5TDH0
Chr Location

1p36.21; chr1:15617458-15669044 (+) GRCh38

MGI Vertebrate Homology

Ddi2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DDI2
Gene Tree

Ddi2

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

25
Chemically induced (other)

2
Endonuclease-mediated

3
Gene trapped

15
Targeted

5
Genomic Mutations

3 involving Ddi2
Find Mice (IMSR)

64 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

19
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

720
Tissues

7
cDNA Data

15
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ddi2

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All Sequences

48
RefSeq

2
UniProt

1
CCDS

CCDS18880.1

Ensembl

ENSMUSG00000078515 (Evidence)
NCBI Gene

68817

			Length	Strain/Species	Flank
genomic	68817	NCBI Gene Model \| MGI Sequence Detail	39857	C57BL/6J	± kb
transcript	NM_001017966	RefSeq \| MGI Sequence Detail	3539	C57BL/6
polypeptide	A2ADY9	UniProt \| EBI \| MGI Sequence Detail	399	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000006346 protein DDI1 homolog 2

(term hierarchy)

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All nucleic 16

cDNA 15

Primer pair 1

Microarray probesets 4

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MGI:1916067, MGI:1921816, MGI:2140343, MGI:2140476

Summaries

All 43

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 17
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:354587 Nedomova M, et al., DDI2 protease controls embryonic development and inflammation via TCF11/NRF1. iScience. 2024 Oct 18;27(10):110893

TSS for Ddi2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr44362	Chr4:141450769-141450777 (-)	-43 bp
Tssr1364	Chr4:141450750-141450765 (-)	-28 bp
Tssr44361	Chr4:141450712-141450747 (-)	0 bp
Tssr44360	Chr4:141450608-141450619 (-)	116 bp
Tssr44359	Chr4:141435713-141435725 (-)	15,011 bp
Tssr44358	Chr4:141423354-141423358 (-)	27,374 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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