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Prpf4 Gene Detail
Summary
  • Symbol
    Prpf4
  • Name
    pre-mRNA processing factor 4
  • Synonyms
    1600015H11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917302
    NCBI Gene: 70052
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:62327034-62345227 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 33.13 cM, cytoband C1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    443 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917302
 protein coding gene Chr4:62327002-62345227 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028351
 protein coding gene Chr4:61394410-61413009 (+)
A/J MGP_AJ_G0028312
 protein coding gene Chr4:59168548-59186556 (+)
AKR/J MGP_AKRJ_G0028261
 protein coding gene Chr4:60805432-60824896 (+)
BALB/cJ MGP_BALBcJ_G0028332
 protein coding gene Chr4:59343784-59361977 (+)
C3H/HeJ MGP_C3HHeJ_G0028050
 protein coding gene Chr4:61313975-61332424 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028772
 protein coding gene Chr4:63498117-63516519 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026078
 protein coding gene Chr4:56458979-56477569 (+)
CAST/EiJ MGP_CASTEiJ_G0027486
 protein coding gene Chr4:59252358-59270856 (+)
CBA/J MGP_CBAJ_G0028017
 protein coding gene Chr4:65692908-65711054 (+)
DBA/2J MGP_DBA2J_G0028167
 protein coding gene Chr4:59026071-59044288 (+)
FVB/NJ MGP_FVBNJ_G0028132
 protein coding gene Chr4:58274652-58293300 (+)
LP/J MGP_LPJ_G0028264
 protein coding gene Chr4:61675439-61693589 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028159
 protein coding gene Chr4:68831862-68850065 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028808
 protein coding gene Chr4:60907463-60926480 (+)
PWK/PhJ MGP_PWKPhJ_G0027213
 protein coding gene Chr4:57505205-57523958 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027042
 protein coding gene Chr4:58356550-58376331 (+)
WSB/EiJ MGP_WSBEiJ_G0027566
 protein coding gene Chr4:60893334-60911541 (+)



Homology
more
  • Human Ortholog
    PRPF4, pre-mRNA splicing tri-snRNP complex factor PRPF4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRPF4, pre-mRNA splicing tri-snRNP complex factor PRPF4
  • Synonyms
    HPRP4, HPRP4P, PRP4, Prp4p, RP70, SNRNP60
  • Links
    NCBI Gene ID: 9128
    neXtProt AC: NX_O43172
    UniProt: O43172

  • Chr Location
    9q32; chr9:113275642-113294009 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PRPF4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    779
  • Tissues
    18
  • cDNA Data
    74
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000066148 Ensembl Gene Model | MGI Sequence Detail 18194 C57BL/6J ±  kb
transcript ENSMUST00000084524 Ensembl | MGI Sequence Detail 5223 Not Applicable  
polypeptide ENSMUSP00000081572 Ensembl | MGI Sequence Detail 521 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 76
    cDNA 75
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
less
MGI:2140401, MGI:2140542
References
more
  • Summaries
    All 35
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 6
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:301700 Cao H, et al., Temporal and tissue specific regulation of RP-associated splicing factor genes PRPF3, PRPF31 and PRPC8--implications in the pathogenesis of RP. PLoS One. 2011 Jan 19;6(1):e15860
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory