Sdr9c7 MGI Mouse Gene Detail - MGI:1917311 - 4short chain dehydrogenase/reductase family 9C, member 7

Symbol

Sdr9c7
Name

4short chain dehydrogenase/reductase family 9C, member 7
Synonyms

1810054F20Rik, Rdh20, Rdhs, Sdro, SDR-O

Feature Type

protein coding gene
IDs

MGI:1917311
NCBI Gene: 70061
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr10:127734404-127747630 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 76.39 cM, cytoband D3
Mapping Data

4 experiments

SNPs within 2kb

478 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917311	protein coding gene	Chr10:127734387-127747630 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017842	protein coding gene	Chr10:131551437-131564871 (+)
A/J	MGP_AJ_G0017817	protein coding gene	Chr10:126297280-126310716 (+)
AKR/J	MGP_AKRJ_G0017780	protein coding gene	Chr10:130009727-130022959 (+)
BALB/cJ	MGP_BALBcJ_G0017781	protein coding gene	Chr10:126680978-126694416 (+)
C3H/HeJ	MGP_C3HHeJ_G0017605	protein coding gene	Chr10:130148655-130161883 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018236	protein coding gene	Chr10:136000547-136022272 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015914	protein coding gene	Chr10:120258727-120271371 (+)
CAST/EiJ	MGP_CASTEiJ_G0017165	protein coding gene	Chr10:130866934-130880440 (+)
CBA/J	MGP_CBAJ_G0017574	protein coding gene	Chr10:141541161-141554383 (+)
DBA/2J	MGP_DBA2J_G0017680	protein coding gene	Chr10:125371565-125384801 (+)
FVB/NJ	MGP_FVBNJ_G0017675	protein coding gene	Chr10:124308483-124321701 (+)
LP/J	MGP_LPJ_G0017754	protein coding gene	Chr10:132169515-132183010 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017703	protein coding gene	Chr10:144156245-144169488 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018276	protein coding gene	Chr10:130104387-130117596 (+)
PWK/PhJ	MGP_PWKPhJ_G0016950	protein coding gene	Chr10:125599732-125613626 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016739	protein coding gene	Chr10:129185258-129198504 (+)
WSB/EiJ	MGP_WSBEiJ_G0017224	protein coding gene	Chr10:130323977-130338307 (+)

Human Ortholog

SDR9C7, short chain dehydrogenase/reductase family 9C member 7

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SDR9C7, short chain dehydrogenase/reductase family 9C member 7
Synonyms

ARCI13, RDHS, SDR-O, SDRO
Links

HGNC:29958

NCBI Gene ID: 121214

neXtProt AC: NX_Q8NEX9

UniProt: Q8NEX9
Chr Location

12q13.3; chr12:56923133-56934408 (-) GRCh38

MGI Vertebrate Homology

Sdr9c7 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: SDR9C7
Gene Tree

Sdr9c7

Diseases

1 with Sdr9c7 mouse models; 1 with human SDR9C7 associations

Human Disease

Mouse Models

autosomal recessive congenital ichthyosis 13

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

12 phenotypes from 2 alleles in 2 genetic backgrounds
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

2
Gene trapped

1
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

27 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous knockout affects the skin barrier function and results in dry skin, trans-epidermal water loss and death within five hours of birth.

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All GO Annotations

7
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

718
Tissues

12
cDNA Data

11
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

35
RefSeq

2
UniProt

1
CCDS

CCDS24256.1

Ensembl

ENSMUSG00000040127 (Evidence)
NCBI Gene

70061

			Length	Strain/Species	Flank
genomic	70061	NCBI Gene Model \| MGI Sequence Detail	13227	C57BL/6J	± kb
transcript	NM_027301	RefSeq \| MGI Sequence Detail	2863	C57BL/6
polypeptide	Q8K3P0	UniProt \| EBI \| MGI Sequence Detail	313	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000031948 short-chain dehydrogenase/reductase family 9C member 7

(term hierarchy)
EC

1.1.1.-
InterPro Domains

IPR036291 NAD(P)-binding domain superfamily

IPR020904 Short-chain dehydrogenase/reductase, conserved site

IPR002347 Short-chain dehydrogenase/reductase SDR

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All nucleic 11

cDNA 11

Microarray probesets 4

Summaries

All 31

Developmental Gene Expression 1

Diseases 1

Gene Ontology 4

Phenotypes 7
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:295441 Takeichi T, et al., SDR9C7 catalyzes critical dehydrogenation of acylceramides for skin barrier formation. J Clin Invest. 2020 Feb 3;130(2):890-903

TSS for Sdr9c7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr96275	Chr10:127734384-127734401 (+)	-11 bp
Tssr96276	Chr10:127734407-127734418 (+)	9 bp
Tssr96277	Chr10:127734419-127734424 (+)	18 bp
Tssr96278	Chr10:127737828-127737849 (+)	3,435 bp
Tssr96279	Chr10:127737869-127737903 (+)	3,482 bp
Tssr96280	Chr10:127737910-127737925 (+)	3,514 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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