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Smc4 Gene Detail
Summary
  • Symbol
    Smc4
  • Name
    structural maintenance of chromosomes 4
  • Synonyms
    2500002A22Rik, Smc4l1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917349
    NCBI Gene: 70099
  • Alliance
    genome feature page
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:68912071-68941956 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 32.14 cM, cytoband E2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    680 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917349
 protein coding gene Chr3:68912071-68941956 (+)
129S1/SvImJ ENSMUSG00200001446
 protein coding gene Chr3:65674468-65703018 (+)
A/J ENSMUSG00195026428
 protein coding gene Chr3:65786365-65814901 (+)
AKR/J ENSMUSG00220023804
 protein coding gene Chr3:65773069-65801605 (+)
BALB/cJ ENSMUSG00180007992
 protein coding gene Chr3:65849173-65877709 (+)
C3H/HeJ ENSMUSG00175003319
 protein coding gene Chr3:65693981-65722513 (+)
C57BL/6NJ ENSMUSG00215005316
 protein coding gene Chr3:66129045-66157594 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025063
 protein coding gene Chr3:62456273-62486401 (+)
CAST/EiJ ENSTCUG00005021614
 protein coding gene Chr3:65299450-65328394 (+)
CBA/J ENSMUSG00210002076
 protein coding gene Chr3:65783259-65811794 (+)
DBA/2J ENSMUSG00185014797
 protein coding gene Chr3:65938213-65966746 (+)
FVB/NJ ENSMUSG00205009207
 protein coding gene Chr3:64843912-64872461 (+)
JF1/MsJ ENSUMUG00000000942
 protein coding gene Chr3:65524414-65553132 (+)
LP/J ENSMUSG00230002218
 protein coding gene Chr3:67961343-67989888 (+)
NOD/ShiLtJ ENSMUSG00190003152
 protein coding gene Chr3:66240412-66268946 (+)
NZO/HlLtJ ENSMUSG00225001453
 protein coding gene Chr3:70659113-70687663 (+)
PWK/PhJ ENSLUMG00010014567
 protein coding gene Chr3:65620986-65649498 (+)
SPRET/EiJ ENSMSPG00010007561
 protein coding gene Chr3:66136611-66166589 (+)
WSB/EiJ ENSIUOG00005015981
 protein coding gene Chr3:66162620-66191111 (+)



Homology
more
  • Human Ortholog
    SMC4, structural maintenance of chromosomes 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SMC4, structural maintenance of chromosomes 4
  • Synonyms
    CAP-C, CAPC, SMC-4, SMC4L1
  • Links
    NCBI Gene ID: 10051
    UniProt: Q9NTJ3

  • Chr Location
    3q25.33; chr3:160399274-160434965 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    50
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    849
  • Tissues
    116
  • cDNA Data
    307
  • Literature Summary
    6
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 70099 NCBI Gene Model | MGI Sequence Detail 29886 C57BL/6J ±  kb
transcript NM_001356976 RefSeq | MGI Sequence Detail 4346 C57BL/6  
polypeptide Q8CG47 UniProt | EBI | MGI Sequence Detail 1286 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 307
    cDNA 307

    Microarray probesets 5
Other
Accession IDs
less
MGI:2140067
References
more
  • Summaries
    All 57
    Developmental Gene Expression 6
    Diseases 1
    Gene Ontology 14
    Phenotypes 14
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:380055 Yang Z, et al., TREM-1 induces pyroptosis in cardiomyocytes by activating NLRP3 inflammasome through the SMC4/NEMO pathway. FEBS J. 2023 Mar;290(6):1549-1562
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory