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Smc4 Gene Detail
Summary
  • Symbol
    Smc4
  • Name
    structural maintenance of chromosomes 4
  • Synonyms
    2500002A22Rik, Smc4l1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917349
    NCBI Gene: 70099
  • Alliance
    gene page
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:68912071-68941956 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 32.14 cM, cytoband E2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    680 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917349
 protein coding gene Chr3:68912071-68941956 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027291
 protein coding gene Chr3:68225775-68259364 (+)
A/J MGP_AJ_G0027253
 protein coding gene Chr3:66190437-66220373 (+)
AKR/J MGP_AKRJ_G0027221
 protein coding gene Chr3:67608106-67638072 (+)
BALB/cJ MGP_BALBcJ_G0027264
 protein coding gene Chr3:66067613-66098512 (+)
C3H/HeJ MGP_C3HHeJ_G0027008
 protein coding gene Chr3:67848756-67879808 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027710
 protein coding gene Chr3:70776446-70808422 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025063
 protein coding gene Chr3:62456273-62486401 (+)
CAST/EiJ MGP_CASTEiJ_G0026455
 protein coding gene Chr3:67800945-67832088 (+)
CBA/J MGP_CBAJ_G0026983
 protein coding gene Chr3:72961096-72992722 (+)
DBA/2J MGP_DBA2J_G0027119
 protein coding gene Chr3:65697787-65728300 (+)
FVB/NJ MGP_FVBNJ_G0027087
 protein coding gene Chr3:64319563-64349857 (+)
LP/J MGP_LPJ_G0027227
 protein coding gene Chr3:69162634-69192840 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027106
 protein coding gene Chr3:77576692-77605259 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027768
 protein coding gene Chr3:67498534-67529886 (+)
PWK/PhJ MGP_PWKPhJ_G0026189
 protein coding gene Chr3:65423690-65454356 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026005
 protein coding gene Chr3:66603217-66633045 (+)
WSB/EiJ MGP_WSBEiJ_G0026533
 protein coding gene Chr3:67654505-67684543 (+)



Homology
more
  • Human Ortholog
    SMC4, structural maintenance of chromosomes 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SMC4, structural maintenance of chromosomes 4
  • Synonyms
    CAP-C, CAPC, SMC-4, SMC4L1
  • Links
    NCBI Gene ID: 10051
    neXtProt AC: NX_Q9NTJ3
    UniProt: Q9NTJ3

  • Chr Location
    3q25.33; chr3:160399274-160434954 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    958
  • Tissues
    116
  • cDNA Data
    307
  • Literature Summary
    6
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 70099 NCBI Gene Model | MGI Sequence Detail 29886 C57BL/6J ±  kb
transcript NM_001356976 RefSeq | MGI Sequence Detail 4346 C57BL/6  
polypeptide Q8CG47 UniProt | EBI | MGI Sequence Detail 1286 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 307
    cDNA 307

    Microarray probesets 5
Other
Accession IDs
less
MGI:2140067
References
more
  • Summaries
    All 52
    Developmental Gene Expression 6
    Diseases 1
    Gene Ontology 12
    Phenotypes 13
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:340308 Sun X, et al., The diapause-like colorectal cancer cells induced by SMC4 attenuation are characterized by low proliferation and chemotherapy insensitivity. Cell Metab. 2023 Sep 5;35(9):1563-1579.e8
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory