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Znhit1 Gene Detail
Summary
  • Symbol
    Znhit1
  • Name
    zinc finger, HIT domain containing 1
  • Synonyms
    2700001K05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917353
    NCBI Gene: 70103
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:137011048-137016813 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 76.09 cM, cytoband G1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    228 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917353
 protein coding gene Chr5:137011018-137016875 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030212
 protein coding gene Chr5:141687294-141693130 (-)
A/J MGP_AJ_G0030180
 protein coding gene Chr5:135554995-135560923 (-)
AKR/J MGP_AKRJ_G0030113
 protein coding gene Chr5:139944721-139951472 (-)
BALB/cJ MGP_BALBcJ_G0030190
 protein coding gene Chr5:136914190-136920032 (-)
C3H/HeJ MGP_C3HHeJ_G0029906
 protein coding gene Chr5:140567480-140573315 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030642
 protein coding gene Chr5:146962729-146968602 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027862
 protein coding gene Chr5:129829864-129833334 (-)
CAST/EiJ MGP_CASTEiJ_G0029316
 protein coding gene Chr5:139985302-139991173 (-)
CBA/J MGP_CBAJ_G0029876
 protein coding gene Chr5:152699059-152704903 (-)
DBA/2J MGP_DBA2J_G0030027
 protein coding gene Chr5:135448941-135454776 (-)
FVB/NJ MGP_FVBNJ_G0029982
 protein coding gene Chr5:134626882-134632721 (-)
LP/J MGP_LPJ_G0030116
 protein coding gene Chr5:142125690-142131575 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030014
 protein coding gene Chr5:155602937-155608775 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030683
 protein coding gene Chr5:139773176-139779014 (-)
PWK/PhJ MGP_PWKPhJ_G0029029
 protein coding gene Chr5:134536802-134542634 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028865
 protein coding gene Chr5:137363477-137369299 (-)
WSB/EiJ MGP_WSBEiJ_G0029389
 protein coding gene Chr5:140516267-140522745 (-)



Homology
more
  • Human Ortholog
    ZNHIT1, zinc finger HIT-type containing 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZNHIT1, zinc finger HIT-type containing 1
  • Synonyms
    CG1I, p18(Hamlet), ZNFN4A1
  • Links
    NCBI Gene ID: 10467
    neXtProt AC: NX_O43257
    UniProt: O43257

  • Chr Location
    7q22.1; chr7:101218165-101224190 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 2 alleles in 3 genetic backgrounds
    1 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show embryonic lethality during peri-implantation stages with abnormal inner cell mass, primitive endoderm, and trophectoderm morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    770
  • Tissues
    19
  • cDNA Data
    95
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 70103 NCBI Gene Model | MGI Sequence Detail 5766 C57BL/6J ±  kb
    transcript NM_027318 RefSeq | MGI Sequence Detail 1131 C57BL/6  
    polypeptide Q8R331 UniProt | EBI | MGI Sequence Detail 154 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 98
      cDNA 95
      Primer pair 3

      Microarray probesets 4
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 5
      Gene Ontology 10
      Phenotypes 14
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:354661 He XD, et al., Overlapping peri-implantation phenotypes of ZNHIT1 and ZNHIT2 despite distinct functions during early mouse development. Biol Reprod. 2024 Aug 28;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory