Ifi35 MGI Mouse Gene Detail - MGI:1917360 - interferon-induced protein 35

Symbol

Ifi35
Name

interferon-induced protein 35
Synonyms

2010008K16Rik, IFP35

Feature Type

protein coding gene
IDs

MGI:1917360
NCBI Gene: 70110
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr11:101339238-101349527 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 65.07 cM, cytoband D
Mapping Data

3 experiments

SNPs within 2kb

374 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917360	protein coding gene	Chr11:101339233-101349527 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019203	protein coding gene	Chr11:104315936-104326725 (+)
A/J	MGP_AJ_G0019171	protein coding gene	Chr11:99930226-99940526 (+)
AKR/J	MGP_AKRJ_G0019140	protein coding gene	Chr11:103036744-103047031 (+)
BALB/cJ	MGP_BALBcJ_G0019145	protein coding gene	Chr11:100422709-100432986 (+)
C3H/HeJ	MGP_C3HHeJ_G0018954	protein coding gene	Chr11:103211524-103223585 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019594	protein coding gene	Chr11:107591139-107601379 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017220	protein coding gene	Chr11:97327228-97338308 (+)
CAST/EiJ	MGP_CASTEiJ_G0018508	protein coding gene	Chr11:104191906-104202266 (+)
CBA/J	MGP_CBAJ_G0018923	protein coding gene	Chr11:112018497-112029933 (+)
DBA/2J	MGP_DBA2J_G0019035	protein coding gene	Chr11:99451702-99462546 (+)
FVB/NJ	MGP_FVBNJ_G0019025	protein coding gene	Chr11:98994933-99004890 (+)
LP/J	MGP_LPJ_G0019104	protein coding gene	Chr11:104856002-104866304 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019056	protein coding gene	Chr11:111575665-111585865 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019632	protein coding gene	Chr11:103366471-103376658 (+)
PWK/PhJ	MGP_PWKPhJ_G0018271	protein coding gene	Chr11:100513947-100524801 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018063	protein coding gene	Chr11:103088788-103100031 (+)
WSB/EiJ	MGP_WSBEiJ_G0018557	protein coding gene	Chr11:103361716-103371977 (+)

Human Ortholog

IFI35, interferon induced protein 35

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IFI35, interferon induced protein 35
Synonyms

IFP35
Links

HGNC:5399

NCBI Gene ID: 3430

neXtProt AC: NX_P80217

UniProt: P80217
Chr Location

17q21.31; chr17:43006740-43014456 (+) GRCh38

MGI Vertebrate Homology

Ifi35 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: IFI35
Gene Tree

Ifi35

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

20
Endonuclease-mediated

1
Gene trapped

15
Targeted

4
Genomic Mutations

1 involving Ifi35
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a different null allele exhibit reduced susceptibility to LPS treatment.

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All GO Annotations

31
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

709
Tissues

1
cDNA Data

75
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ifi35

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All Sequences

36
RefSeq

2
UniProt

2
CCDS

CCDS25471.1

Ensembl

ENSMUSG00000010358 (Evidence)
NCBI Gene

70110

			Length	Strain/Species	Flank
genomic	70110	NCBI Gene Model \| MGI Sequence Detail	10290	C57BL/6J	± kb
transcript	NM_027320	RefSeq \| MGI Sequence Detail	1360	C57BL/6
polypeptide	Q9D8C4	UniProt \| EBI \| MGI Sequence Detail	286	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000008906 interferon-induced 35 kDa protein

(term hierarchy)
InterPro Domains

IPR009909 Nmi/IFP 35 domain

IPR009938 Nmi/IFP 35 domain, N-terminal

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

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All nucleic 75

cDNA 75

Microarray probesets 5

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MGI:2144592

Summaries

All 44

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 15
Earliest

J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
Latest

J:309551 Jing X, et al., IFP35 family proteins promote neuroinflammation and multiple sclerosis. Proc Natl Acad Sci U S A. 2021 Aug 10;118(32):e2102642118

TSS for Ifi35:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr105119	Chr11:101339229-101339313 (+)	33 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24