Lipn MGI Mouse Gene Detail - MGI:1917416

Symbol

Lipn
Name

lipase, family member N
Synonyms

2210418G03Rik, Lipl4

Feature Type

protein coding gene
IDs

MGI:1917416
NCBI Gene: 70166
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr19:34044758-34062318 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 29.32 cM, cytoband C3
Mapping Data

2 experiments

SNPs within 2kb

557 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917416	protein coding gene	Chr19:34044458-34063346 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025051	protein coding gene	Chr19:32797692-32819649 (+)
A/J	MGP_AJ_G0025029	protein coding gene	Chr19:31204984-31223182 (+)
AKR/J	MGP_AKRJ_G0024995	protein coding gene	Chr19:32256309-32276635 (+)
BALB/cJ	MGP_BALBcJ_G0025025	protein coding gene	Chr19:31317491-31335768 (+)
C3H/HeJ	MGP_C3HHeJ_G0024784	protein coding gene	Chr19:32360097-32387533 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025466	protein coding gene	Chr19:33742697-33762195 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022884	protein coding gene	Chr19:30658522-30675736 (+)
CAST/EiJ	MGP_CASTEiJ_G0024254	protein coding gene	Chr19:32093713-32122054 (+)
CBA/J	MGP_CBAJ_G0024761	protein coding gene	Chr19:35324391-35348874 (+)
DBA/2J	MGP_DBA2J_G0024893	protein coding gene	Chr19:31103986-31124641 (+)
FVB/NJ	MGP_FVBNJ_G0024854	protein coding gene	Chr19:30951166-30971608 (+)
LP/J	MGP_LPJ_G0024979	protein coding gene	Chr19:32890613-32912183 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024885	protein coding gene	Chr19:35143404-35162903 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025524	protein coding gene	Chr19:32352064-32373519 (+)
PWK/PhJ	MGP_PWKPhJ_G0024003	protein coding gene	Chr19:30917947-30924504 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023804	protein coding gene	Chr19:31212711-31232868 (+)
WSB/EiJ	MGP_WSBEiJ_G0024318	protein coding gene	Chr19:32437111-32456559 (+)

Human Ortholog

LIPN, lipase family member N

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LIPN, lipase family member N
Synonyms

ARCI8, bA186O14.3, LI4, LIPL4
Links

HGNC:23452

NCBI Gene ID: 643418

neXtProt AC: NX_Q5VXI9

UniProt: Q5VXI9
Chr Location

10q23.31; chr10:88757226-88779626 (+) GRCh38

MGI Vertebrate Homology

Lipn stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: LIPN
Protein SuperFamily

Steryl_ester_lip
Gene Tree

Lipn

Diseases

1 with human LIPN associations

				Human Disease	Mouse Models
				autosomal recessive congenital ichthyosis 8 IDs autosomal recessive congenital ichthyosis 8 DOID:0060717 ICD10CM:Q80.2 OMIM:613943

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

3
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

32 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

4
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

721
Tissues

14
cDNA Data

3
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

36
RefSeq

4
UniProt

4
CCDS

CCDS37962.1

Ensembl

ENSMUSG00000024770 (Evidence)
NCBI Gene

70166

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024770	Ensembl Gene Model \| MGI Sequence Detail	17561	C57BL/6J	± kb
transcript	ENSMUST00000025682	Ensembl \| MGI Sequence Detail	1502	Not Applicable
polypeptide	ENSMUSP00000025682	Ensembl \| MGI Sequence Detail	400	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000009841 lipase member N

(term hierarchy)
EC

3.1.1.-
InterPro Domains

IPR029058 Alpha/Beta hydrolase fold

IPR000073 Alpha/beta hydrolase fold-1

IPR025483 Lipase, eukaryotic

IPR006693 Partial AB-hydrolase lipase domain
GlyGen

Q3U4B4 1 site

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All nucleic 4

cDNA 3

Primer pair 1

Microarray probesets 2

Summaries

All 29

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 8
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Lipn:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr156031	Chr19:34044746-34044762 (+)	-4 bp
Tssr156032	Chr19:34044790-34044802 (+)	38 bp
Tssr156033	Chr19:34044925-34044934 (+)	172 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24