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Nars1 Gene Detail
Summary
  • Symbol
    Nars1
  • Name
    asparaginyl-tRNA synthetase 1
  • Synonyms
    ASNRS, Nars
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917473
    NCBI Gene: 70223
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:64632726-64649586 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 37.47 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    620 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917473
 protein coding gene Chr18:64632718-64649723 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024504
 protein coding gene Chr18:64555938-64573801 (-)
A/J MGP_AJ_G0024471
 protein coding gene Chr18:61773578-61791440 (-)
AKR/J MGP_AKRJ_G0024441
 protein coding gene Chr18:63502181-63520157 (-)
BALB/cJ MGP_BALBcJ_G0024470
 protein coding gene Chr18:61919696-61937284 (-)
C3H/HeJ MGP_C3HHeJ_G0024238
 protein coding gene Chr18:63719410-63736814 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024917
 protein coding gene Chr18:66285808-66304350 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022348
 protein coding gene Chr18:61218707-61235472 (-)
CAST/EiJ MGP_CASTEiJ_G0023711
 protein coding gene Chr18:63636718-63656502 (-)
CBA/J MGP_CBAJ_G0024208
 protein coding gene Chr18:68434090-68455136 (-)
DBA/2J MGP_DBA2J_G0024338
 protein coding gene Chr18:61440528-61457418 (-)
FVB/NJ MGP_FVBNJ_G0024304
 protein coding gene Chr18:60819158-60836457 (-)
LP/J MGP_LPJ_G0024422
 protein coding gene Chr18:64420637-64438943 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024333
 protein coding gene Chr18:69931766-69950431 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024964
 protein coding gene Chr18:63714256-63731119 (-)
PWK/PhJ MGP_PWKPhJ_G0023454
 protein coding gene Chr18:61668913-61686995 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023259
 protein coding gene Chr18:63865382-63884180 (-)
WSB/EiJ MGP_WSBEiJ_G0023775
 protein coding gene Chr18:63573183-63589963 (-)



Homology
more
  • Human Ortholog
    NARS1, asparaginyl-tRNA synthetase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NARS1, asparaginyl-tRNA synthetase 1
  • Synonyms
    ASNRS, NARS, NEDMILEG, NEDMILG
  • Links
    NCBI Gene ID: 4677
    neXtProt AC: NX_O43776
    UniProt: O43776

  • Chr Location
    18q21.31; chr18:57600656-57622213 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 3 alleles in 3 genetic backgrounds
    1 images
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show complete embryonic lethality prior to organogenesis. In vitro, blastocysts do not hatch from the zona pellucida or form outgrowths after 3 days in culture.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    20
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    802
  • Tissues
    95
  • cDNA Data
    305
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 70223 NCBI Gene Model | MGI Sequence Detail 16861 C57BL/6J ±  kb
transcript NM_001377021 RefSeq | MGI Sequence Detail 2603 C57BL/6  
polypeptide Q8BP47 UniProt | EBI | MGI Sequence Detail 559 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    11 Sequences
  • Protein Ontology
    PR:000010992 asparagine--tRNA ligase, cytoplasmic
    (term hierarchy)
  • EC
    6.1.1.22
  • InterPro Domains
    IPR006195 Aminoacyl-tRNA synthetase, class II
    IPR004364 Aminoacyl-tRNA synthetase, class II (D/K/N)
    IPR004522 Asparagine-tRNA ligase
    IPR048952 Asparagine--tRNA ligase, N-terminal domain
    IPR002312 Aspartyl/Asparaginyl-tRNA synthetase, class IIb
    IPR045864 Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL)
    IPR012340 Nucleic acid-binding, OB-fold
    IPR004365 OB-fold nucleic acid binding domain, AA-tRNA synthetase-type
  • GlyGen
    Q8BP47 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 306
    cDNA 305
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
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MGI:2147188, MGI:2147403, MGI:7484194
References
more
  • Summaries
    All 44
    Developmental Gene Expression 3
    Gene Ontology 7
    Phenotypes 13
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:348677 Beijer D, et al., Nars1 mutations causing axonal Charcot-Marie-Tooth disease expand NARS1-associated diseases. Brain Commun. 2024;6(2)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory