Dazap1 MGI Mouse Gene Detail - MGI:1917498

Symbol

Dazap1
Name

DAZ associated protein 1
Synonyms

2410042M16Rik, mPrrp

Feature Type

protein coding gene
IDs

MGI:1917498
NCBI Gene: 70248
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr10:80097320-80124242 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM
Mapping Data

3 experiments

SNPs within 2kb

501 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917498	protein coding gene	Chr10:80097168-80124242 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017492	protein coding gene	Chr10:80858786-80886260 (+)
A/J	MGP_AJ_G0017470	protein coding gene	Chr10:78025571-78053789 (+)
AKR/J	MGP_AKRJ_G0017431	protein coding gene	Chr10:80157026-80187824 (+)
BALB/cJ	MGP_BALBcJ_G0017432	protein coding gene	Chr10:78256893-78284561 (+)
C3H/HeJ	MGP_C3HHeJ_G0017255	protein coding gene	Chr10:80253506-80282967 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017886	protein coding gene	Chr10:83647606-83690138 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015574	protein coding gene	Chr10:74248449-74275447 (+)
CAST/EiJ	MGP_CASTEiJ_G0016822	protein coding gene	Chr10:80458355-80487035 (+)
CBA/J	MGP_CBAJ_G0017227	protein coding gene	Chr10:86888445-86915254 (+)
DBA/2J	MGP_DBA2J_G0017333	protein coding gene	Chr10:77246495-77273285 (+)
FVB/NJ	MGP_FVBNJ_G0017327	protein coding gene	Chr10:76431620-76460582 (+)
LP/J	MGP_LPJ_G0017404	protein coding gene	Chr10:81331467-81359991 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017353	protein coding gene	Chr10:88832381-88860761 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017927	protein coding gene	Chr10:80143334-80176288 (+)
PWK/PhJ	MGP_PWKPhJ_G0016603	protein coding gene	Chr10:77114031-77141776 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016392	protein coding gene	Chr10:79124253-79150830 (+)
WSB/EiJ	MGP_WSBEiJ_G0016882	protein coding gene	Chr10:80179451-80209776 (+)

Human Ortholog

DAZAP1, DAZ associated protein 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DAZAP1, DAZ associated protein 1
Links

HGNC:2683

NCBI Gene ID: 26528

neXtProt AC: NX_Q96EP5

UniProt: Q96EP5
Chr Location

19p13.3; chr19:1407569-1435687 (+) GRCh38

MGI Vertebrate Homology

Dazap1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DAZAP1
Gene Tree

Dazap1

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Phenotype Summary

29 phenotypes from 4 alleles in 2 genetic backgrounds
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

47
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

38
Targeted

5
Genomic Mutations

1 involving Dazap1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

40 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a null allele show partial lethality during fetal growth through weaning, growth retardation, spermatogenic arrest, and premature death. Homozygotes for a hypomorphic allele live longer but are small and sterile and display small gonads, spermatogenic arrest, and abnormal pregnancy.

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All GO Annotations

29
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

856
Tissues

129
cDNA Data

90
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dazap1

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All Sequences

77
RefSeq

26
UniProt

6
CCDS

CCDS35977.1, CCDS48626.1, CCDS48627.1

Ensembl

ENSMUSG00000069565 (Evidence)
NCBI Gene

70248

			Length	Strain/Species	Flank
genomic	ENSMUSG00000069565	Ensembl Gene Model \| MGI Sequence Detail	26923	C57BL/6J	± kb
transcript	ENSMUST00000105361	Ensembl \| MGI Sequence Detail	1537	Not Applicable
polypeptide	ENSMUSP00000101000	Ensembl \| MGI Sequence Detail	406	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000006288 DAZ-associated protein 1

(term hierarchy)
InterPro Domains

IPR034134 DAZ-associated protein 1, RNA recognition motif 1

IPR034131 DAZ-associated protein 1, RNA recognition motif 2

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR035979 RNA-binding domain superfamily

IPR000504 RNA recognition motif domain

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All nucleic 95

cDNA 90

Primer pair 3

Other 2

Microarray probesets 3

Summaries

All 50

Developmental Gene Expression 3

Gene Ontology 11

Phenotypes 19
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Dazap1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94530	Chr10:80097291-80097336 (+)	-6 bp
Tssr94531	Chr10:80100776-80100867 (+)	3,502 bp
Tssr94532	Chr10:80100869-80100920 (+)	3,575 bp
Tssr94533	Chr10:80100921-80100988 (+)	3,635 bp
Tssr94535	Chr10:80116240-80116243 (+)	18,922 bp
Tssr94536	Chr10:80116762-80116810 (+)	19,466 bp
Tssr94537	Chr10:80118855-80118869 (+)	21,542 bp
Tssr94538	Chr10:80120324-80120341 (+)	23,013 bp
Tssr94539	Chr10:80121087-80121112 (+)	23,780 bp
Tssr94540	Chr10:80121159-80121188 (+)	23,854 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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