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Pggt1b Gene Detail
Summary
  • Symbol
    Pggt1b
  • Name
    protein geranylgeranyltransferase type I, beta subunit
  • Synonyms
    2010207C17Rik, BGG1, GGT1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917514
    NCBI Gene: 225467
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:46368418-46414060 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 24.45 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1210 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917514
 protein coding gene Chr18:46368411-46414173 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024405
 protein coding gene Chr18:45028963-45076203 (-)
A/J MGP_AJ_G0024372
 protein coding gene Chr18:43402770-43445981 (-)
AKR/J MGP_AKRJ_G0024341
 protein coding gene Chr18:44598933-44645664 (-)
BALB/cJ MGP_BALBcJ_G0024372
 protein coding gene Chr18:43518209-43560611 (-)
C3H/HeJ MGP_C3HHeJ_G0024139
 protein coding gene Chr18:44684338-44728787 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024816
 protein coding gene Chr18:46604813-46650099 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022251
 protein coding gene Chr18:43254497-43295155 (-)
CAST/EiJ MGP_CASTEiJ_G0023613
 protein coding gene Chr18:44649106-44692082 (-)
CBA/J MGP_CBAJ_G0024108
 protein coding gene Chr18:47858931-47903119 (-)
DBA/2J MGP_DBA2J_G0024238
 protein coding gene Chr18:43031000-43073072 (-)
FVB/NJ MGP_FVBNJ_G0024204
 protein coding gene Chr18:42597184-42638284 (-)
LP/J MGP_LPJ_G0024322
 protein coding gene Chr18:45081244-45133612 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024235
 protein coding gene Chr18:49224130-49273215 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024863
 protein coding gene Chr18:44513955-44558184 (-)
PWK/PhJ MGP_PWKPhJ_G0023357
 protein coding gene Chr18:43162163-43204886 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023162
 protein coding gene Chr18:44675392-44720098 (-)
WSB/EiJ MGP_WSBEiJ_G0023676
 protein coding gene Chr18:44408626-44456838 (-)



Homology
more
  • Human Ortholog
    PGGT1B, protein geranylgeranyltransferase type I subunit beta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PGGT1B, protein geranylgeranyltransferase type I subunit beta
  • Synonyms
    BGGI, GGTI
  • Links
    NCBI Gene ID: 5229
    neXtProt AC: NX_P53609
    UniProt: P53609

  • Chr Location
    5q22.3; chr5:115204012-115262877 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    23 phenotypes from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene blocks proliferation of primary mouse fibroblasts, disrupts the actin cytoskeleton, and results in altered cell morphology and reduced cell migration in a standard wound healing assay.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    21
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024477 Ensembl Gene Model | MGI Sequence Detail 45643 C57BL/6J ±  kb
    transcript ENSMUST00000236216 Ensembl | MGI Sequence Detail 7477 Not Applicable  
    polypeptide ENSMUSP00000158214 Ensembl | MGI Sequence Detail 377 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 21

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:2143611, MGI:2147241
    References
    more
    • Summaries
      All 58
      Gene Ontology 6
      Phenotypes 28
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:327181 Lewis MA, et al., Identification and characterisation of spontaneous mutations causing deafness from a targeted knockout programme. BMC Biol. 2022 Mar 17;20(1):67
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory