Bclaf1 MGI Mouse Gene Detail - MGI:1917580 - BCL2-associated transcription factor 1

Symbol

Bclaf1
Name

BCL2-associated transcription factor 1
Synonyms

2610102K23Rik, 2700025J07Rik, 2810454G14Rik, 5730534O06Rik, mKIAA0164

Feature Type

protein coding gene
IDs

MGI:1917580
NCBI Gene: 72567
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr10:20187897-20218390 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 9.75 cM, cytoband A3
Mapping Data

3 experiments

SNPs within 2kb

519 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917580	protein coding gene	Chr10:20187897-20220359 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017054	protein coding gene	Chr10:18055151-18088410 (+)
A/J	MGP_AJ_G0017032	protein coding gene	Chr10:17367501-17399665 (+)
AKR/J	MGP_AKRJ_G0016996	protein coding gene	Chr10:17681627-17716552 (+)
BALB/cJ	MGP_BALBcJ_G0016990	protein coding gene	Chr10:17436273-17468364 (+)
C3H/HeJ	MGP_C3HHeJ_G0016815	protein coding gene	Chr10:17996659-18028781 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017452	protein coding gene	Chr10:18510977-18543040 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015157	protein coding gene	Chr10:16363269-16396181 (+)
CAST/EiJ	MGP_CASTEiJ_G0016397	protein coding gene	Chr10:17866362-17899969 (+)
CBA/J	MGP_CBAJ_G0016787	protein coding gene	Chr10:19342479-19376677 (+)
DBA/2J	MGP_DBA2J_G0016895	protein coding gene	Chr10:17252723-17284888 (+)
FVB/NJ	MGP_FVBNJ_G0016890	protein coding gene	Chr10:17007238-17039433 (+)
LP/J	MGP_LPJ_G0016970	protein coding gene	Chr10:17856569-17891506 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016920	protein coding gene	Chr10:19586384-19623415 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017490	protein coding gene	Chr10:17663229-17695906 (+)
PWK/PhJ	MGP_PWKPhJ_G0016182	protein coding gene	Chr10:17127982-17161293 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015965	protein coding gene	Chr10:17808895-17845334 (+)
WSB/EiJ	MGP_WSBEiJ_G0016459	protein coding gene	Chr10:17747500-17779603 (+)

Human Ortholog

BCLAF1, BCL2 associated transcription factor 1

Vertebrate Orthologs

1

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BCLAF1, BCL2 associated transcription factor 1
Synonyms

bK211L9.1, BTF
Links

HGNC:16863

NCBI Gene ID: 9774

neXtProt AC: NX_Q9NYF8

UniProt: Q9NYF8
Chr Location

6q23.3; chr6:136256627-136289851 (-) GRCh38

MGI Vertebrate Homology

Bclaf1 stringent orthology
1 human;1 mouse
HCOP

vertebrate homology predictions: BCLAF1
Gene Tree

Bclaf1

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Phenotype Summary

19 phenotypes from 3 alleles in 3 genetic backgrounds
27 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

71
Chemically induced (other)

1
Endonuclease-mediated

5
Gene trapped

59
Targeted

5
Transgenic

1
Genomic Mutations

1 involving Bclaf1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

62 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit postnatal lethality, impaired lung development, and T cell and B cell homeostasis abnormalities.

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All GO Annotations

21
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

804
Tissues

82
cDNA Data

406
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase bclaf1

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All Sequences

103
RefSeq

16
UniProt

11
CCDS

CCDS23721.1, CCDS35858.1, CCDS78798.1

Ensembl

ENSMUSG00000037608 (Evidence)
NCBI Gene

72567

			Length	Strain/Species	Flank
genomic	72567	NCBI Gene Model \| MGI Sequence Detail	30494	C57BL/6J	± kb
transcript	NM_001025392	RefSeq \| MGI Sequence Detail	5454	Not Specified
polypeptide	Q8K019	UniProt \| EBI \| MGI Sequence Detail	919	Not Applicable

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UniProt

11 Sequences
Protein Ontology

PR:000004706 Bcl-2-associated transcription factor 1

(term hierarchy)
InterPro Domains

IPR029199 THRAP3/BCLAF1 family
GlyGen

Q8K019 1 site, 1 O-linked glycan (1 site)

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All nucleic 408

cDNA 407

Primer pair 1

Microarray probesets 7

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MGI:1914501, MGI:1917913, MGI:1919817, MGI:2143607, MGI:2143868

Summaries

All 66

Developmental Gene Expression 9

Gene Ontology 8

Phenotypes 27
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Bclaf1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr92593	Chr10:20188109-20188146 (+)	231 bp
Tssr92594	Chr10:20188207-20188238 (+)	326 bp
Tssr92595	Chr10:20188244-20188264 (+)	357 bp
Tssr92596	Chr10:20188270-20188285 (+)	381 bp
Tssr92597	Chr10:20188701-20188722 (+)	815 bp
Tssr92598	Chr10:20195894-20195895 (+)	7,998 bp
Tssr92599	Chr10:20201121-20201145 (+)	13,236 bp
Tssr92600	Chr10:20202704-20202709 (+)	14,810 bp
Tssr92601	Chr10:20207847-20207878 (+)	19,966 bp
Tssr92602	Chr10:20207906-20207940 (+)	20,026 bp
Tssr92603	Chr10:20215497-20215513 (+)	27,608 bp
Tssr92604	Chr10:20216972-20216976 (+)	29,077 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24