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Shprh Gene Detail
Summary
  • Symbol
    Shprh
  • Name
    SNF2 histone linker PHD RING helicase
  • Synonyms
    2610103K11Rik, D230017O13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917581
    NCBI Gene: 268281
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:11025171-11093339 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 3.66 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1647 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917581
 protein coding gene Chr10:11024765-11093339 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017012
 protein coding gene Chr10:8518888-8589368 (+)
A/J MGP_AJ_G0016990
 protein coding gene Chr10:8132088-8202158 (+)
AKR/J MGP_AKRJ_G0016954
 protein coding gene Chr10:8334908-8403014 (+)
BALB/cJ MGP_BALBcJ_G0016948
 protein coding gene Chr10:8144864-8213088 (+)
C3H/HeJ MGP_C3HHeJ_G0016773
 protein coding gene Chr10:8500052-8568370 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017410
 protein coding gene Chr10:8719669-8794309 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015115
 protein coding gene Chr10:7527286-7598216 (+)
CAST/EiJ MGP_CASTEiJ_G0016355
 protein coding gene Chr10:8358750-8433265 (+)
CBA/J MGP_CBAJ_G0016745
 protein coding gene Chr10:9029623-9102377 (+)
DBA/2J MGP_DBA2J_G0016853
 protein coding gene Chr10:8050343-8118580 (+)
FVB/NJ MGP_FVBNJ_G0016848
 protein coding gene Chr10:7952593-8021538 (+)
LP/J MGP_LPJ_G0016928
 protein coding gene Chr10:8316017-8386341 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016878
 protein coding gene Chr10:8946429-9033430 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017448
 protein coding gene Chr10:8271217-8341464 (+)
PWK/PhJ MGP_PWKPhJ_G0016140
 protein coding gene Chr10:7969140-8039891 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015923
 protein coding gene Chr10:8316597-8390882 (+)
WSB/EiJ MGP_WSBEiJ_G0016417
 protein coding gene Chr10:8289522-8358946 (+)



Homology
more
  • Human Ortholog
    SHPRH, SNF2 histone linker PHD RING helicase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SHPRH, SNF2 histone linker PHD RING helicase
  • Synonyms
    bA545I5.2, RAD5
  • Links
    NCBI Gene ID: 257218
    neXtProt AC: NX_Q149N8
    UniProt: Q149N8

  • Chr Location
    6q24.3; chr6:145857838-145964423 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
The gene product is an E3 ligase involved in poly-ubiquitination of Pcna. Neither homozygous truncation nor KO affect B cell somatic hypermutation or class switching.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    19
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000090112 Ensembl Gene Model | MGI Sequence Detail 68169 C57BL/6J ±  kb
    transcript ENSMUST00000044053 Ensembl | MGI Sequence Detail 9271 Not Applicable  
    polypeptide ENSMUSP00000039422 Ensembl | MGI Sequence Detail 1674 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 23

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2441961, MGI:2446137, MGI:3035103, MGI:3035296
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory