Ppp4r1 MGI Mouse Gene Detail - MGI:1917601 - protein phosphatase 4, regulatory subunit 1

Symbol

Ppp4r1
Name

protein phosphatase 4, regulatory subunit 1
Synonyms

3110001J10Rik, Pp4r1

Feature Type

protein coding gene
IDs

MGI:1917601
NCBI Gene: 70351
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr17:66089568-66148921 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 35.26 cM, cytoband E1.2
Mapping Data

2 experiments

SNPs within 2kb

1648 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917601	protein coding gene	Chr17:66089253-66148921 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023980	protein coding gene	Chr17:67936577-67997684 (+)
A/J	MGP_AJ_G0023938	protein coding gene	Chr17:65897798-65957321 (+)
AKR/J	MGP_AKRJ_G0023907	protein coding gene	Chr17:66818893-66887585 (+)
BALB/cJ	MGP_BALBcJ_G0023939	protein coding gene	Chr17:65849577-65912837 (+)
C3H/HeJ	MGP_C3HHeJ_G0023703	protein coding gene	Chr17:67708891-67773068 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024385	protein coding gene	Chr17:70554116-70619827 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021831	protein coding gene	Chr17:61931328-61994870 (+)
CAST/EiJ	MGP_CASTEiJ_G0023185	protein coding gene	Chr17:68048014-68111172 (+)
CBA/J	MGP_CBAJ_G0023679	protein coding gene	Chr17:73312325-73383630 (+)
DBA/2J	MGP_DBA2J_G0023807	protein coding gene	Chr17:64645002-64708839 (+)
FVB/NJ	MGP_FVBNJ_G0023773	protein coding gene	Chr17:64133426-64193467 (+)
LP/J	MGP_LPJ_G0023889	protein coding gene	Chr17:68650911-68713257 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023801	protein coding gene	Chr17:73416060-73480850 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024429	protein coding gene	Chr17:67276969-67341430 (+)
PWK/PhJ	MGP_PWKPhJ_G0022931	protein coding gene	Chr17:63892915-63977728 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022742	protein coding gene	Chr17:63962835-64025175 (+)
WSB/EiJ	MGP_WSBEiJ_G0023251	protein coding gene	Chr17:67988224-68049470 (+)

Human Ortholog

PPP4R1, protein phosphatase 4 regulatory subunit 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PPP4R1, protein phosphatase 4 regulatory subunit 1
Synonyms

MEG1, PP4R1, PP4(Rmeg)
Links

HGNC:9320

NCBI Gene ID: 9989

neXtProt AC: NX_Q8TF05

UniProt: Q8TF05
Chr Location

18p11.22; chr18:9546791-9617199 (-) GRCh38

MGI Vertebrate Homology

Ppp4r1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PPP4R1
Gene Tree

Ppp4r1

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

33
Endonuclease-mediated

1
Gene trapped

32
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

36 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

2
GO References

1

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

736
Tissues

30
cDNA Data

12
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ppp4r1

ZFIN ppp4r1

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All Sequences

98
RefSeq

28
UniProt

11
CCDS

CCDS28941.2, CCDS50167.1

Ensembl

ENSMUSG00000061950 (Evidence)
NCBI Gene

70351

			Length	Strain/Species	Flank
genomic	ENSMUSG00000061950	Ensembl Gene Model \| MGI Sequence Detail	59354	C57BL/6J	± kb
transcript	ENSMUST00000073104	Ensembl \| MGI Sequence Detail	3850	Not Applicable
polypeptide	ENSMUSP00000072848	Ensembl \| MGI Sequence Detail	951	Not Applicable

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UniProt

11 Sequences
Protein Ontology

PR:000013153 serine/threonine-protein phosphatase 4 regulatory subunit 1

(term hierarchy)
InterPro Domains

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR000357 HEAT repeat

IPR021133 HEAT, type 2

IPR051023 Protein Phosphatase 2A Regulatory Subunit A

IPR033461 Putative WW-binding domain and destruction box
GlyGen

Q8K2V1 1 site, 1 O-linked glycan (1 site)

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All nucleic 12

cDNA 12

Microarray probesets 6

Summaries

All 33

Developmental Gene Expression 2

Gene Ontology 1

Phenotypes 11
Earliest

J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ppp4r1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr145572	Chr17:66089696-66089721 (+)	141 bp
Tssr145573	Chr17:66089979-66090099 (+)	471 bp
Tssr145574	Chr17:66090101-66090172 (+)	569 bp
Tssr145577	Chr17:66101160-66101206 (+)	11,615 bp
Tssr145578	Chr17:66106206-66106210 (+)	16,640 bp
Tssr145579	Chr17:66107024-66107027 (+)	17,458 bp
Tssr145580	Chr17:66107031-66107041 (+)	17,468 bp
Tssr145581	Chr17:66107044-66107053 (+)	17,481 bp
Tssr145582	Chr17:66107058-66107070 (+)	17,496 bp
Tssr145583	Chr17:66124050-66124056 (+)	34,485 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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