Secisbp2l MGI Mouse Gene Detail - MGI:1917604 - SECIS binding protein 2-like

Symbol

Secisbp2l
Name

SECIS binding protein 2-like
Synonyms

3110001I20Rik

Feature Type

protein coding gene
IDs

MGI:1917604
NCBI Gene: 70354
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr2:125578906-125624790 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 61.76 cM
Mapping Data

2 experiments

SNPs within 2kb

1024 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917604	protein coding gene	Chr2:125578906-125624790 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0026433	protein coding gene	Chr2:128940182-128989970 (-)
A/J	MGP_AJ_G0026396	protein coding gene	Chr2:123687444-123734197 (-)
AKR/J	MGP_AKRJ_G0026372	protein coding gene	Chr2:127219392-127267556 (-)
BALB/cJ	MGP_BALBcJ_G0026408	protein coding gene	Chr2:123978272-124024016 (-)
C3H/HeJ	MGP_C3HHeJ_G0026152	protein coding gene	Chr2:127707578-127754703 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0026854	protein coding gene	Chr2:133042497-133095653 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024231	protein coding gene	Chr2:118467841-118516463 (-)
CAST/EiJ	MGP_CASTEiJ_G0025613	protein coding gene	Chr2:127959067-128008400 (-)
CBA/J	MGP_CBAJ_G0026132	protein coding gene	Chr2:137864875-137917713 (-)
DBA/2J	MGP_DBA2J_G0026266	protein coding gene	Chr2:123103089-123148764 (-)
FVB/NJ	MGP_FVBNJ_G0026230	protein coding gene	Chr2:121790222-121837562 (-)
LP/J	MGP_LPJ_G0026371	protein coding gene	Chr2:129168792-129216009 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026250	protein coding gene	Chr2:141986071-142035609 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026909	protein coding gene	Chr2:127257873-127304160 (-)
PWK/PhJ	MGP_PWKPhJ_G0025349	protein coding gene	Chr2:122643543-122689265 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0025151	protein coding gene	Chr2:126337378-126389417 (-)
WSB/EiJ	MGP_WSBEiJ_G0025687	protein coding gene	Chr2:128164532-128212474 (-)

Human Ortholog

SECISBP2L, SECIS binding protein 2 like

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SECISBP2L, SECIS binding protein 2 like
Synonyms

SBP2L, SLAN
Links

HGNC:28997

NCBI Gene ID: 9728

neXtProt AC: NX_Q93073

UniProt: Q93073
Chr Location

15q21.1; chr15:48988476-49046447 (-) GRCh38

MGI Vertebrate Homology

Secisbp2l stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SECISBP2L
Gene Tree

Secisbp2l

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Phenotype Summary

18 phenotypes from 2 alleles in 2 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

1
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Secisbp2l
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

73 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice with loss of expression in oligodendrocytes show impaired differentiation of oligodendrocytes with decreased T3 and increased T4 levels.

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All GO Annotations

5
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

119
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase secisbp2l

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All Sequences

55
RefSeq

6
UniProt

7
CCDS

CCDS38230.1

Ensembl

ENSMUSG00000035093 (Evidence)
NCBI Gene

70354

			Length	Strain/Species	Flank
genomic	70354	NCBI Gene Model \| MGI Sequence Detail	45885	C57BL/6J	± kb
transcript	NM_177608	RefSeq \| MGI Sequence Detail	6797	C57BL/6
polypeptide	Q6A098	UniProt \| EBI \| MGI Sequence Detail	1086	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000014602 selenocysteine insertion sequence-binding protein 2-like

(term hierarchy)
InterPro Domains

IPR029064 Ribosomal protein eL30-like superfamily

IPR004038 Ribosomal protein eL8/eL30/eS12/Gadd45

IPR040051 Selenocysteine insertion sequence-binding protein 2

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All nucleic 119

cDNA 119

Microarray probesets 3

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MGI:2138988

Summaries

All 33

Developmental Gene Expression 1

Gene Ontology 2

Phenotypes 10
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Secisbp2l:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr26021	Chr2:125624754-125624765 (-)	30 bp
Tssr26020	Chr2:125624735-125624746 (-)	49 bp
Tssr26019	Chr2:125624694-125624722 (-)	82 bp
Tssr26018	Chr2:125624654-125624692 (-)	117 bp
Tssr26017	Chr2:125624632-125624650 (-)	149 bp
Tssr26016	Chr2:125622483-125622506 (-)	2,295 bp
Tssr26015	Chr2:125617527-125617549 (-)	7,252 bp
Tssr26014	Chr2:125615332-125615390 (-)	9,429 bp
Tssr26013	Chr2:125609904-125609908 (-)	14,884 bp
Tssr26012	Chr2:125602302-125602323 (-)	22,477 bp
Tssr26011	Chr2:125579805-125579810 (-)	44,982 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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