Gprc5c MGI Mouse Gene Detail - MGI:1917605 - G protein-coupled receptor, family C, group 5, member C

Symbol

Gprc5c
Name

G protein-coupled receptor, family C, group 5, member C
Synonyms

1110028I06Rik, 3200002M13Rik

Feature Type

protein coding gene
IDs

MGI:1917605
NCBI Gene: 70355
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr11:114741978-114763443 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 80.54 cM
Mapping Data

2 experiments

SNPs within 2kb

686 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917605	protein coding gene	Chr11:114741976-114763443 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019362	protein coding gene	Chr11:118803307-118824683 (+)
A/J	MGP_AJ_G0019331	protein coding gene	Chr11:113635022-113659612 (+)
AKR/J	MGP_AKRJ_G0019299	protein coding gene	Chr11:116997235-117016557 (+)
BALB/cJ	MGP_BALBcJ_G0019304	protein coding gene	Chr11:114050290-114069240 (+)
C3H/HeJ	MGP_C3HHeJ_G0019113	protein coding gene	Chr11:117346811-117372513 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019755	protein coding gene	Chr11:122370698-122391216 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017378	protein coding gene	Chr11:110696949-110716624 (+)
CAST/EiJ	MGP_CASTEiJ_G0018667	protein coding gene	Chr11:118680835-118704463 (+)
CBA/J	MGP_CBAJ_G0019083	protein coding gene	Chr11:127269945-127294871 (+)
DBA/2J	MGP_DBA2J_G0019195	protein coding gene	Chr11:113073099-113092685 (+)
FVB/NJ	MGP_FVBNJ_G0019186	protein coding gene	Chr11:112558470-112580164 (+)
LP/J	MGP_LPJ_G0019265	protein coding gene	Chr11:119208082-119232495 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019217	protein coding gene	Chr11:126414767-126436362 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019792	protein coding gene	Chr11:117674179-117694244 (+)
PWK/PhJ	MGP_PWKPhJ_G0018432	protein coding gene	Chr11:114310723-114332860 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018224	protein coding gene	Chr11:117478465-117500071 (+)
WSB/EiJ	MGP_WSBEiJ_G0018719	protein coding gene	Chr11:117633310-117654510 (+)

Human Ortholog

GPRC5C, G protein-coupled receptor class C group 5 member C

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GPRC5C, G protein-coupled receptor class C group 5 member C
Synonyms

RAIG-3, RAIG3
Links

HGNC:13309

NCBI Gene ID: 55890

neXtProt AC: NX_Q9NQ84

UniProt: Q9NQ84
Chr Location

17q25.1; chr17:74424851-74451658 (+) GRCh38

MGI Vertebrate Homology

Gprc5c stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GPRC5C
Gene Tree

Gprc5c

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

24
Endonuclease-mediated

4
Gene trapped

19
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

62 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a reporter allele are behaviorally normal but exhibit reticulocytosis, increased mean corpuscular volume, increased percentage of basophils, decreased mean corpuscular hemogloblin concentration, and increased alkaline phophatase and lactic dehydrogenase levels.

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All GO Annotations

12
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

754
Tissues

41
cDNA Data

61
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

ZFIN gprc5c

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All Sequences

81
RefSeq

16
UniProt

9
CCDS

CCDS25612.1, CCDS48978.1

Ensembl

ENSMUSG00000051043 (Evidence)
NCBI Gene

70355

			Length	Strain/Species	Flank
genomic	ENSMUSG00000051043	Ensembl Gene Model \| MGI Sequence Detail	21466	C57BL/6J	± kb
transcript	ENSMUST00000053361	Ensembl \| MGI Sequence Detail	3667	Not Applicable
polypeptide	ENSMUSP00000061760	Ensembl \| MGI Sequence Detail	441	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000008196 G-protein coupled receptor family C group 5 member C

(term hierarchy)
InterPro Domains

IPR002956 Bride of sevenless protein

IPR017978 GPCR family 3, C-terminal

IPR051753 Retinoic acid-inducible GPCR family 3
GlyGen

Q8K3J9 1 site

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All nucleic 66

cDNA 63

Primer pair 1

Other 2

Microarray probesets 6

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MGI:1915929

Summaries

All 40

Developmental Gene Expression 6

Gene Ontology 6

Phenotypes 10
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Gprc5c:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr105792	Chr11:114741948-114741966 (+)	-21 bp
Tssr105793	Chr11:114741968-114741984 (+)	-2 bp
Tssr105794	Chr11:114742218-114742252 (+)	257 bp
Tssr105795	Chr11:114742333-114742379 (+)	378 bp
Tssr105796	Chr11:114742427-114742438 (+)	455 bp
Tssr105797	Chr11:114742441-114742472 (+)	479 bp
Tssr105798	Chr11:114742483-114742492 (+)	510 bp
Tssr105799	Chr11:114742640-114742694 (+)	689 bp
Tssr105800	Chr11:114742733-114742788 (+)	783 bp
Tssr105801	Chr11:114742854-114742868 (+)	883 bp
Tssr105802	Chr11:114742879-114742901 (+)	912 bp
Tssr105803	Chr11:114743009-114743017 (+)	1,035 bp
Tssr105804	Chr11:114743045-114743068 (+)	1,079 bp
Tssr105805	Chr11:114763206-114763217 (+)	21,234 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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