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Lman1 Gene Detail
Summary
  • Symbol
    Lman1
  • Name
    lectin, mannose-binding, 1
  • Synonyms
    2610020P13Rik, ERGIC53, F5F8D, gp58, MCFD1, MR60, P58
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917611
    NCBI Gene: 70361
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:66113810-66135706 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 39.08 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    810 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917611
 protein coding gene Chr18:66113809-66155651 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024515
 protein coding gene Chr18:66171323-66214783 (-)
A/J MGP_AJ_G0024482
 protein coding gene Chr18:63281740-63323322 (-)
AKR/J MGP_AKRJ_G0024452
 protein coding gene Chr18:65070888-65113484 (-)
BALB/cJ MGP_BALBcJ_G0024481
 protein coding gene Chr18:63424240-63469602 (-)
C3H/HeJ MGP_C3HHeJ_G0024249
 protein coding gene Chr18:65284486-65329531 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024928
 protein coding gene Chr18:67929092-67972320 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022359
 protein coding gene Chr18:62721906-62762732 (-)
CAST/EiJ MGP_CASTEiJ_G0023722
 protein coding gene Chr18:65287358-65330762 (-)
CBA/J MGP_CBAJ_G0024219
 protein coding gene Chr18:70172222-70224102 (-)
DBA/2J MGP_DBA2J_G0024349
 protein coding gene Chr18:62948631-62994847 (-)
FVB/NJ MGP_FVBNJ_G0024315
 protein coding gene Chr18:62326726-62369747 (-)
LP/J MGP_LPJ_G0024433
 protein coding gene Chr18:66018634-66064176 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024344
 protein coding gene Chr18:71560264-71604444 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024975
 protein coding gene Chr18:65283269-65327179 (-)
PWK/PhJ MGP_PWKPhJ_G0023465
 protein coding gene Chr18:63204743-63247395 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023270
 protein coding gene Chr18:65440450-65482359 (-)
WSB/EiJ MGP_WSBEiJ_G0023786
 protein coding gene Chr18:65148737-65193137 (-)



Homology
more
  • Human Ortholog
    LMAN1, lectin, mannose binding 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LMAN1, lectin, mannose binding 1
  • Synonyms
    ERGIC-53, ERGIC53, F5F8D, FMFD1, gp58, MCFD1, MR60
  • Links
    NCBI Gene ID: 3998
    neXtProt AC: NX_P49257
    UniProt: P49257

  • Chr Location
    18q21.32; chr18:59327823-59359265 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human LMAN1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 7 genetic backgrounds
    4 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit strain dependent postnatal lethality, slightly dilated endoplasmic reticulum in hepatocytes, and decreased serum levels of factor V and VII and aspartate transaminase with accumulation of those proteins in those ER of hepatocytes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    710
  • Tissues
    3
  • cDNA Data
    17
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 70361 NCBI Gene Model | MGI Sequence Detail 21897 C57BL/6J ±  kb
    transcript NM_027400 RefSeq | MGI Sequence Detail 3576 C57BL/6  
    polypeptide Q9D0F3 UniProt | EBI | MGI Sequence Detail 517 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 17
      Primer pair 1

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:2147213, MGI:2147326
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 6
      Gene Ontology 18
      Phenotypes 13
    • Earliest
      J:33331 Nishiguchi S, et al., A catalogue of genes in mouse embryonal carcinoma F9 cells identified with expressed sequence tags. J Biochem. 1996 Apr;119(4):749-67
    • Latest
      J:341713 Aure MH, et al., FGFR2 is essential for salivary gland duct homeostasis and MAPK-dependent seromucous acinar cell differentiation. Nat Commun. 2023 Oct 14;14(1):6485
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory