Fndc5 MGI Mouse Gene Detail - MGI:1917614 - fibronectin type III domain containing 5

Symbol

Fndc5
Name

fibronectin type III domain containing 5
Synonyms

1500001L03Rik, PeP, Pxp

Feature Type

protein coding gene
IDs

MGI:1917614
NCBI Gene: 384061
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr4:129030672-129038386 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 62.93 cM
Mapping Data

2 experiments

SNPs within 2kb

102 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917614	protein coding gene	Chr4:129030477-129038386 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028814	protein coding gene	Chr4:130994540-131003821 (+)
A/J	MGP_AJ_G0028773	protein coding gene	Chr4:125810647-125818220 (+)
AKR/J	MGP_AKRJ_G0028726	protein coding gene	Chr4:129299185-129306807 (+)
BALB/cJ	MGP_BALBcJ_G0028796	protein coding gene	Chr4:126389235-126396821 (+)
C3H/HeJ	MGP_C3HHeJ_G0028510	protein coding gene	Chr4:129348049-129355627 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029238	protein coding gene	Chr4:135958670-135966234 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026511	protein coding gene	Chr4:118937686-118945386 (+)
CAST/EiJ	MGP_CASTEiJ_G0027943	protein coding gene	Chr4:127525505-127533236 (+)
CBA/J	MGP_CBAJ_G0028476	protein coding gene	Chr4:139279885-139287485 (+)
DBA/2J	MGP_DBA2J_G0028625	protein coding gene	Chr4:126237007-126244596 (+)
FVB/NJ	MGP_FVBNJ_G0028592	protein coding gene	Chr4:124994356-125001937 (+)
LP/J	MGP_LPJ_G0028726	protein coding gene	Chr4:131308431-131316039 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028618	protein coding gene	Chr4:144181575-144189163 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029276	protein coding gene	Chr4:129668445-129676038 (+)
PWK/PhJ	MGP_PWKPhJ_G0027664	protein coding gene	Chr4:122811642-122820739 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027491	protein coding gene	Chr4:125523714-125531350 (+)
WSB/EiJ	MGP_WSBEiJ_G0028023	protein coding gene	Chr4:129777393-129784997 (+)

Human Ortholog

FNDC5, fibronectin type III domain containing 5

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FNDC5, fibronectin type III domain containing 5
Synonyms

FRCP2, irisin
Links

HGNC:20240

NCBI Gene ID: 252995

neXtProt AC: NX_Q8NAU1

UniProt: Q8NAU1
Chr Location

1p35.1; chr1:32862268-32872484 (-) GRCh38

MGI Vertebrate Homology

Fndc5 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: FNDC5
Gene Tree

Fndc5

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Phenotype Summary

17 phenotypes from 2 alleles in 2 genetic backgrounds
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Chemically induced (other)

2
Endonuclease-mediated

7
Gene trapped

1
Radiation induced

1
Targeted

5
Genomic Mutations

4 involving Fndc5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out mice exhibit increased trabecular bone mass and bone connectivity density with resistance to ovariectomy-induced osteoporosis. Homozygous KO also increases susceptibility to diet-induced obesity, hepatic steatosis, cardiac hypertrophy and cardiac inflammation.

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All GO Annotations

12
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

792
Tissues

47
cDNA Data

31
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA FNDC5

ZFIN fndc5b

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All Sequences

47
RefSeq

4
UniProt

1
CCDS

CCDS18683.1

Ensembl

ENSMUSG00000001334 (Evidence)
NCBI Gene

384061

			Length	Strain/Species	Flank
genomic	384061	NCBI Gene Model \| MGI Sequence Detail	7715	C57BL/6J	± kb
transcript	NM_027402	RefSeq \| MGI Sequence Detail	2779	C57BL/6
polypeptide	Q8K4Z2	UniProt \| EBI \| MGI Sequence Detail	209	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000030681 fibronectin type III domain-containing protein 5

(term hierarchy)
InterPro Domains

IPR003961 Fibronectin type III

IPR052120 Fibronectin type III domain-containing protein

IPR036116 Fibronectin type III superfamily

IPR013783 Immunoglobulin-like fold
GlyGen

Q8K4Z2 2 sites, 2 N-linked glycans (2 sites)

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All nucleic 34

cDNA 32

Primer pair 2

Microarray probesets 4

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MGI:2140366

Summaries

All 72

Developmental Gene Expression 4

Gene Ontology 7

Phenotypes 21
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:351143 Li RL, et al., Irisin attenuates vascular remodeling in hypertensive mice induced by Ang II by suppressing Ca(2+)-dependent endoplasmic reticulum stress in VSMCs. Int J Biol Sci. 2024;20(2):680-700

TSS for Fndc5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr39124	Chr4:129030477-129030497 (+)	-185 bp
Tssr39125	Chr4:129030652-129030669 (+)	-11 bp
Tssr39126	Chr4:129030670-129030696 (+)	11 bp
Tssr39127	Chr4:129030713-129030734 (+)	52 bp
Tssr39128	Chr4:129030741-129030766 (+)	82 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24