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Cox10 Gene Detail
Summary
  • Symbol
    Cox10
  • Name
    heme A:farnesyltransferase cytochrome c oxidase assembly factor 10
  • Synonyms
    2410004F01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917633
    NCBI Gene: 70383
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:63853453-63970294 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 39.47 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3021 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917633
 protein coding gene Chr11:63853453-63970298 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018470
 protein coding gene Chr11:64101944-64224557 (-)
A/J MGP_AJ_G0018439
 protein coding gene Chr11:61712486-61835042 (-)
AKR/J MGP_AKRJ_G0018408
 protein coding gene Chr11:63625102-63750237 (-)
BALB/cJ MGP_BALBcJ_G0018410
 protein coding gene Chr11:61985174-62102890 (-)
C3H/HeJ MGP_C3HHeJ_G0018223
 protein coding gene Chr11:63585597-63704502 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018862
 protein coding gene Chr11:66070069-66196618 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016506
 protein coding gene Chr11:58764252-58882393 (-)
CAST/EiJ MGP_CASTEiJ_G0017779
 protein coding gene Chr11:63755996-63895471 (-)
CBA/J MGP_CBAJ_G0018197
 protein coding gene Chr11:68969602-69088901 (-)
DBA/2J MGP_DBA2J_G0018306
 protein coding gene Chr11:61274154-61394853 (-)
FVB/NJ MGP_FVBNJ_G0018296
 protein coding gene Chr11:60925644-61043009 (-)
LP/J MGP_LPJ_G0018378
 protein coding gene Chr11:64633357-64758673 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018320
 protein coding gene Chr11:69892218-70024831 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018903
 protein coding gene Chr11:63789624-63906242 (-)
PWK/PhJ MGP_PWKPhJ_G0017553
 protein coding gene Chr11:61863446-62004289 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017343
 protein coding gene Chr11:63638693-63764383 (-)
WSB/EiJ MGP_WSBEiJ_G0017832
 protein coding gene Chr11:63403717-63522654 (-)



Homology
more
  • Human Ortholog
    COX10, cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    COX10, cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10
  • Synonyms
    MC4DN3
  • Links
    NCBI Gene ID: 1352
    neXtProt AC: NX_Q12887
    UniProt: Q12887

  • Chr Location
    17p12; chr17:14069490-14231736 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with Cox10 mouse models; 1 with human COX10 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 1 allele in 3 genetic backgrounds
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    814
  • Tissues
    97
  • cDNA Data
    44
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042148 Ensembl Gene Model | MGI Sequence Detail 116842 C57BL/6J ±  kb
    transcript ENSMUST00000049091 Ensembl | MGI Sequence Detail 2915 Not Applicable  
    polypeptide ENSMUSP00000040138 Ensembl | MGI Sequence Detail 443 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 46
      cDNA 44
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2144433
    References
    more
    • Summaries
      All 77
      Developmental Gene Expression 3
      Diseases 3
      Gene Ontology 12
      Phenotypes 41
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:350558 Spate E, et al., Downregulated expression of lactate dehydrogenase in adult oligodendrocytes and its implication for the transfer of glycolysis products to axons. Glia. 2024 Aug;72(8):1374-1391
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory