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Asnsd1 Gene Detail
Summary
  • Symbol
    Asnsd1
  • Name
    asparagine synthetase domain containing 1
  • Synonyms
    2210409M21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917646
    NCBI Gene: 70396
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr1:53383776-53391911 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 26.99 cM, cytoband C1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    337 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917646
 protein coding gene Chr1:53383776-53391911 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016021
 protein coding gene Chr1:52889278-52897964 (-)
A/J MGP_AJ_G0016003
 protein coding gene Chr1:51104375-51112522 (-)
AKR/J MGP_AKRJ_G0015959
 protein coding gene Chr1:52222340-52230474 (-)
BALB/cJ no annotation
C3H/HeJ MGP_C3HHeJ_G0015791
 protein coding gene Chr1:52601602-52610457 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016411
 protein coding gene Chr1:55067451-55077017 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014113
 protein coding gene Chr1:40776633-40784898 (+)
CAST/EiJ MGP_CASTEiJ_G0015373
 protein coding gene Chr1:52090369-52098527 (-)
CBA/J MGP_CBAJ_G0015762
 protein coding gene Chr1:56578282-56586054 (-)
DBA/2J MGP_DBA2J_G0015864
 protein coding gene Chr1:50378043-50387678 (-)
FVB/NJ MGP_FVBNJ_G0015866
 protein coding gene Chr1:49835646-49843781 (-)
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0015886
 protein coding gene Chr1:59651688-59659863 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016459
 protein coding gene Chr1:52338378-52347081 (-)
PWK/PhJ MGP_PWKPhJ_G0015159
 protein coding gene Chr1:50227265-50237997 (-)
SPRET/EiJ MGP_SPRETEiJ_G0014939
 protein coding gene Chr1:51997001-52005155 (-)
WSB/EiJ MGP_WSBEiJ_G0015436
 protein coding gene Chr1:52141608-52149739 (-)



Homology
more
  • Human Ortholog
    ASNSD1, asparagine synthetase domain containing 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ASNSD1, asparagine synthetase domain containing 1
  • Synonyms
    NBLA00058, NS3TP1
  • Links
    NCBI Gene ID: 54529
    neXtProt AC: NX_Q9NWL6
    UniProt: Q9NWL6

  • Chr Location
    2q32.2; chr2:189661385-189670831 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Asnsd1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced viability at weaning, handling-induced seizures, and decreased systolic blood pressure, and develop a progressive degenerative myopathy with severe muscle weakness and myosteatosis but no signs of lipotoxicity despite extremely increased body fat percentage and low skeletal muscle mass.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    797
  • Tissues
    5
  • cDNA Data
    132
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 70396 NCBI Gene Model | MGI Sequence Detail 8136 C57BL/6J ±  kb
    transcript NM_133728 RefSeq | MGI Sequence Detail 2450 C57BL/6  
    polypeptide Q8BFS9 UniProt | EBI | MGI Sequence Detail 627 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    Molecular
    Reagents
    less
    • All nucleic 133
      cDNA 133

      Microarray probesets 5
    References
    more
    • Summaries
      All 30
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 3
      Phenotypes 9
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory