Polr3b MGI Mouse Gene Detail - MGI:1917678 - polymerase (RNA) III (DNA directed) polypeptide B

Symbol

Polr3b
Name

polymerase (RNA) III (DNA directed) polypeptide B
Synonyms

2700078H01Rik, A330032P03Rik, RPC2

Feature Type

protein coding gene
IDs

MGI:1917678
NCBI Gene: 70428
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr10:84458156-84563042 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 41.58 cM, cytoband C1
Mapping Data

3 experiments

SNPs within 2kb

2685 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917678	protein coding gene	Chr10:84458156-84563042 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017593	protein coding gene	Chr10:85495674-85607967 (+)
A/J	MGP_AJ_G0017573	protein coding gene	Chr10:82596843-82702359 (+)
AKR/J	MGP_AKRJ_G0017532	protein coding gene	Chr10:84891938-85005026 (+)
BALB/cJ	MGP_BALBcJ_G0017536	protein coding gene	Chr10:82845959-82949711 (+)
C3H/HeJ	MGP_C3HHeJ_G0017358	protein coding gene	Chr10:84976428-85091442 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017993	protein coding gene	Chr10:88394973-88514114 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015677	protein coding gene	Chr10:78419453-78522267 (+)
CAST/EiJ	MGP_CASTEiJ_G0016925	protein coding gene	Chr10:84831437-84938304 (+)
CBA/J	MGP_CBAJ_G0017328	protein coding gene	Chr10:92105351-92225469 (+)
DBA/2J	MGP_DBA2J_G0017434	protein coding gene	Chr10:81739386-81843874 (+)
FVB/NJ	MGP_FVBNJ_G0017428	protein coding gene	Chr10:80974270-81080867 (+)
LP/J	MGP_LPJ_G0017506	protein coding gene	Chr10:86136331-86242121 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017456	protein coding gene	Chr10:93701563-93810009 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018030	protein coding gene	Chr10:84817893-84924450 (+)
PWK/PhJ	MGP_PWKPhJ_G0016706	protein coding gene	Chr10:81599900-81707254 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016495	protein coding gene	Chr10:83440299-83550860 (+)
WSB/EiJ	MGP_WSBEiJ_G0016984	protein coding gene	Chr10:84803817-84913415 (+)

Human Ortholog

POLR3B, RNA polymerase III subunit B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

POLR3B, RNA polymerase III subunit B
Synonyms

C128, CMT1I, HLD8, INMAP, RPC2
Links

HGNC:30348

NCBI Gene ID: 55703

neXtProt AC: NX_Q9NW08

UniProt: Q9NW08
Chr Location

12q23.3; chr12:106357748-106510198 (+) GRCh38

MGI Vertebrate Homology

Polr3b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: POLR3B
Gene Tree

Polr3b

Diseases

2 with human POLR3B associations

				Human Disease	Mouse Models
				Charcot-Marie-Tooth disease IDs Charcot-Marie-Tooth disease DOID:10595 ICD10CM:G60.0 ICD9CM_2006:356.1 ICD9CM:356.1 MESH:D002607 NCI:C75467 OMIM:PS118220 UMLS_CUI:C0007959
				hypomyelinating leukodystrophy 8 IDs hypomyelinating leukodystrophy 8 DOID:0060797 ICD10CM:G11.1 OMIM:614381

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

37
Chemically induced (other)

1
Endonuclease-mediated

8
Gene trapped

26
Targeted

2
Genomic Mutations

1 involving Polr3b
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

102 strains or lines available

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All GO Annotations

33
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

800
Tissues

94
cDNA Data

75
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA POLR3B

Xenbase polr3b

ZFIN polr3b

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All Sequences

43
RefSeq

3
UniProt

4
CCDS

CCDS24081.1

Ensembl

ENSMUSG00000034453 (Evidence)
NCBI Gene

70428

			Length	Strain/Species	Flank
genomic	70428	NCBI Gene Model \| MGI Sequence Detail	104887	C57BL/6J	± kb
transcript	NM_027423	RefSeq \| MGI Sequence Detail	4997	Not Specified
polypeptide	P59470	UniProt \| EBI \| MGI Sequence Detail	1133	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000013001 DNA-directed RNA polymerase III subunit RPC2

(term hierarchy)
EC

2.7.7.6
InterPro Domains

IPR015712 DNA-directed RNA polymerase, subunit 2

IPR007120 DNA-directed RNA polymerase, subunit 2, hybrid-binding domain

IPR037033 DNA-directed RNA polymerase, subunit 2, hybrid-binding domain superfamily

IPR007121 RNA polymerase, beta subunit, conserved site

IPR007644 RNA polymerase, beta subunit, protrusion

IPR007642 RNA polymerase Rpb2, domain 2

IPR037034 RNA polymerase Rpb2, domain 2 superfamily

IPR007645 RNA polymerase Rpb2, domain 3

IPR007646 RNA polymerase Rpb2, domain 4

IPR007647 RNA polymerase Rpb2, domain 5

IPR007641 RNA polymerase Rpb2, domain 7

IPR014724 RNA polymerase Rpb2, OB-fold

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All nucleic 75

cDNA 75

Microarray probesets 5

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MGI:2143941, MGI:2443266

Summaries

All 56

Developmental Gene Expression 1

Gene Ontology 10

Phenotypes 20
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:358530 Malik Y, et al., Disruption of tRNA biogenesis enhances proteostatic resilience, improves later-life health, and promotes longevity. PLoS Biol. 2024 Oct;22(10):e3002853

TSS for Polr3b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94902	Chr10:84458144-84458167 (+)	0 bp
Tssr94903	Chr10:84458176-84458224 (+)	44 bp
Tssr94904	Chr10:84458229-84458274 (+)	96 bp
Tssr94905	Chr10:84475609-84475633 (+)	17,465 bp
Tssr94906	Chr10:84482470-84482519 (+)	24,339 bp
Tssr94907	Chr10:84488464-84488465 (+)	30,309 bp
Tssr94908	Chr10:84544046-84544051 (+)	85,893 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24