Rufy2 MGI Mouse Gene Detail - MGI:1917682 - RUN and FYVE domain-containing 2

Symbol

Rufy2
Name

RUN and FYVE domain-containing 2
Synonyms

2610111M19Rik, Denn, LZ-FYVE, ZFYVE13

Feature Type

protein coding gene
IDs

MGI:1917682
NCBI Gene: 70432
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr10:62816002-62852989 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 32.51 cM, cytoband B4
Mapping Data

4 experiments

SNPs within 2kb

983 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917682	protein coding gene	Chr10:62815947-62852989 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017309	protein coding gene	Chr10:62467853-62509640 (+)
A/J	MGP_AJ_G0017287	protein coding gene	Chr10:60531695-60568518 (+)
AKR/J	MGP_AKRJ_G0017247	protein coding gene	Chr10:62126350-62166126 (+)
BALB/cJ	MGP_BALBcJ_G0017247	protein coding gene	Chr10:60640173-60682484 (+)
C3H/HeJ	MGP_C3HHeJ_G0017070	protein coding gene	Chr10:62043399-62084311 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017705	protein coding gene	Chr10:64705120-64755614 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015395	protein coding gene	Chr10:57473233-57510675 (+)
CAST/EiJ	MGP_CASTEiJ_G0016641	protein coding gene	Chr10:62095079-62134487 (+)
CBA/J	MGP_CBAJ_G0017042	protein coding gene	Chr10:67162964-67201642 (+)
DBA/2J	MGP_DBA2J_G0017147	protein coding gene	Chr10:59804415-59841257 (+)
FVB/NJ	MGP_FVBNJ_G0017141	protein coding gene	Chr10:59073022-59110800 (+)
LP/J	MGP_LPJ_G0017221	protein coding gene	Chr10:62838009-62878756 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017169	protein coding gene	Chr10:69329526-69373037 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017743	protein coding gene	Chr10:61967230-62005737 (+)
PWK/PhJ	MGP_PWKPhJ_G0016424	protein coding gene	Chr10:59685051-59722077 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016206	protein coding gene	Chr10:61320681-61357960 (+)
WSB/EiJ	MGP_WSBEiJ_G0016705	protein coding gene	Chr10:61920802-61961356 (+)

Human Ortholog

RUFY2, RUN and FYVE domain containing 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RUFY2, RUN and FYVE domain containing 2
Synonyms

RABIP4R, ZFYVE13
Links

HGNC:19761

NCBI Gene ID: 55680

neXtProt AC: NX_Q8WXA3

UniProt: Q8WXA3
Chr Location

10q21.3; chr10:68341107-68407294 (-) GRCh38

MGI Vertebrate Homology

Rufy2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RUFY2
Gene Tree

Rufy2

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

3
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Rufy2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

31 strains or lines available

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All GO Annotations

7
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

790
Tissues

66
cDNA Data

21
Literature Summary

6

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rufy2

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All Sequences

82
RefSeq

16
UniProt

9
CCDS

CCDS48582.1

Ensembl

ENSMUSG00000020070 (Evidence)
NCBI Gene

70432

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020070	Ensembl Gene Model \| MGI Sequence Detail	36988	C57BL/6J	± kb
transcript	ENSMUST00000119567	Ensembl \| MGI Sequence Detail	4130	Not Applicable
polypeptide	ENSMUSP00000113429	Ensembl \| MGI Sequence Detail	606	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000031903 RUN and FYVE domain-containing protein 2

(term hierarchy)
InterPro Domains

IPR000306 FYVE zinc finger

IPR047335 RUN and FYVE domain-containing protein 1-3

IPR047333 RUN and FYVE domain-containing protein 2, FYVE domain

IPR047332 RUN and FYVE domain-containing protein 2, RUN domain

IPR004012 RUN domain

IPR037213 RUN domain superfamily

IPR011011 Zinc finger, FYVE/PHD-type

IPR017455 Zinc finger, FYVE-related

IPR013083 Zinc finger, RING/FYVE/PHD-type

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All nucleic 26

cDNA 21

Primer pair 5

Microarray probesets 10

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MGD-MRK-37142, MGI:108105, MGI:2143680

Summaries

All 53

Developmental Gene Expression 6

Gene Ontology 5

Phenotypes 15
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rufy2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr93740	Chr10:62816012-62816040 (+)	24 bp
Tssr93741	Chr10:62816059-62816070 (+)	63 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24