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Wdr77 Gene Detail
Summary
  • Symbol
    Wdr77
  • Name
    WD repeat domain 77
  • Synonyms
    2610003I18Rik, 2610312E17Rik, p44/MEP50
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917715
    NCBI Gene: 70465
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:105866814-105877076 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 46.46 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    397 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917715
 protein coding gene Chr3:105866685-105877353 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027725
 protein coding gene Chr3:107348511-107359040 (+)
A/J MGP_AJ_G0027685
 protein coding gene Chr3:103914925-103927167 (+)
AKR/J MGP_AKRJ_G0027650
 protein coding gene Chr3:106492517-106503046 (+)
BALB/cJ MGP_BALBcJ_G0027697
 protein coding gene Chr3:103696267-103706796 (+)
C3H/HeJ MGP_C3HHeJ_G0027427
 protein coding gene Chr3:106836623-106847152 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028141
 protein coding gene Chr3:111353312-111363841 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025481
 protein coding gene Chr3:99988520-99999099 (+)
CAST/EiJ MGP_CASTEiJ_G0026883
 protein coding gene Chr3:105993862-106006100 (+)
CBA/J MGP_CBAJ_G0027402
 protein coding gene Chr3:115101007-115111536 (+)
DBA/2J MGP_DBA2J_G0027544
 protein coding gene Chr3:103159234-103169763 (+)
FVB/NJ MGP_FVBNJ_G0027512
 protein coding gene Chr3:101082492-101093021 (+)
LP/J MGP_LPJ_G0027651
 protein coding gene Chr3:108750784-108761313 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027542
 protein coding gene Chr3:121227584-121240848 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028196
 protein coding gene Chr3:106066906-106077442 (+)
PWK/PhJ MGP_PWKPhJ_G0026609
 protein coding gene Chr3:102940728-102952363 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026430
 protein coding gene Chr3:104069909-104080437 (+)
WSB/EiJ MGP_WSBEiJ_G0026963
 protein coding gene Chr3:106601985-106615248 (+)



Homology
more
  • Human Ortholog
    WDR77, WD repeat domain 77
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WDR77, WD repeat domain 77
  • Synonyms
    HKMT1069, MEP-50, MEP50, Nbla10071, p44, p44/Mep50
  • Links
    NCBI Gene ID: 79084
    neXtProt AC: NX_Q9BQA1
    UniProt: Q9BQA1

  • Chr Location
    1p13.2; chr1:111439890-111449256 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 3 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele die prior to E8.5 for unknown reasons. Heterozygotes develop multifocal hyperplasia in the dorsal prostate; however, no prostate tumors are detected up to 12 months of age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    828
  • Tissues
    82
  • cDNA Data
    206
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 70465 NCBI Gene Model | MGI Sequence Detail 10263 C57BL/6J ±  kb
    transcript NM_027432 RefSeq | MGI Sequence Detail 3553 C57BL/6  
    polypeptide Q99J09 UniProt | EBI | MGI Sequence Detail 342 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 207
      cDNA 207

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1923782, MGI:2140070
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 12
      Phenotypes 13
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:338972 Li J, et al., WDR77 inhibits prion-like aggregation of MAVS to limit antiviral innate immune response. Nat Commun. 2023 Aug 10;14(1):4824
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory