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Filip1 Gene Detail
Summary
  • Symbol
    Filip1
  • Name
    filamin A interacting protein 1
  • Synonyms
    5730485H21Rik, FILIP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1917848
    NCBI Gene: 70598
  • Alliance
    gene page
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:79712376-79920133 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 43.83 cM, cytoband E2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5914 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1917848
 protein coding gene Chr9:79708461-79920135 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035077
 protein coding gene Chr9:80356825-80525003 (-)
A/J MGP_AJ_G0035058
 protein coding gene Chr9:77613094-77767385 (-)
AKR/J MGP_AKRJ_G0034986
 protein coding gene Chr9:79415965-79581342 (-)
BALB/cJ MGP_BALBcJ_G0035046
 protein coding gene Chr9:77233594-77390801 (-)
C3H/HeJ MGP_C3HHeJ_G0034758
 protein coding gene Chr9:79941586-80104732 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035569
 protein coding gene Chr9:82547987-82712549 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032476
 protein coding gene Chr9:76746649-76905052 (-)
CAST/EiJ MGP_CASTEiJ_G0034076
 protein coding gene Chr9:80284641-80450089 (-)
CBA/J MGP_CBAJ_G0034731
 protein coding gene Chr9:85489119-85668543 (-)
DBA/2J MGP_DBA2J_G0034889
 protein coding gene Chr9:77222526-77374591 (-)
FVB/NJ MGP_FVBNJ_G0034832
 protein coding gene Chr9:76435072-76594088 (-)
LP/J MGP_LPJ_G0034970
 protein coding gene Chr9:80616424-80777593 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034874
 protein coding gene Chr9:86723906-86894281 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035590
 protein coding gene Chr9:79638998-79812309 (-)
PWK/PhJ MGP_PWKPhJ_G0033780
 protein coding gene Chr9:77421733-77576670 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033616
 protein coding gene Chr9:79773416-79940707 (-)
WSB/EiJ MGP_WSBEiJ_G0034193
 protein coding gene Chr9:79573849-79742488 (-)



Homology
more
  • Human Ortholog
    FILIP1, filamin A interacting protein 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FILIP1, filamin A interacting protein 1
  • Synonyms
    FILIP, NMDF
  • Links
    NCBI Gene ID: 27145
    neXtProt AC: NX_Q7Z7B0
    UniProt: Q7Z7B0

  • Chr Location
    6q14.1; chr6:75291859-75493800 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit altered positioning of cortical neurons and altered localization of the callosal projection neurons, decreased dendritic spine length of piriform cortex pyramidal neurons, and impaired propagation of excitation in the visual cortex.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    7
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    771
  • Tissues
    16
  • cDNA Data
    19
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034898 Ensembl Gene Model | MGI Sequence Detail 207758 C57BL/6J ±  kb
    transcript ENSMUST00000093811 Ensembl | MGI Sequence Detail 4640 Not Applicable  
    polypeptide ENSMUSP00000091329 Ensembl | MGI Sequence Detail 1214 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000007524 filamin-A-interacting protein 1
      (term hierarchy)
    • InterPro Domains
      IPR050719 Cortactin-binding and Actin Dynamics Regulator
      IPR019131 Cortactin-binding protein-2, N-terminal
    • GlyGen
      Q9CS72 6 sites, 1 O-linked glycan (6 sites)
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 19

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2143134
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 15
    • Earliest
      J:12013 Russell LB, Definition of functional units in a small chromosomal segment of the mouse and its use in interpreting the nature of radiation-induced mutations. Mutat Res. 1971 Jan;11(1):107-23
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory