Zfp398 MGI Mouse Gene Detail - MGI:1917856

Symbol

Zfp398
Name

zinc finger protein 398
Synonyms

5730513I23Rik

Feature Type

protein coding gene
IDs

MGI:1917856
NCBI Gene: 272347
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr6:47812595-47850471 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 22.94 cM, cytoband B3
Mapping Data

3 experiments

SNPs within 2kb

757 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917856	protein coding gene	Chr6:47812567-47850476 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030685	protein coding gene	Chr6:46742725-46777917 (+)
A/J	MGP_AJ_G0030657	protein coding gene	Chr6:44589486-44621039 (+)
AKR/J	MGP_AKRJ_G0030582	protein coding gene	Chr6:46143203-46177939 (+)
BALB/cJ	MGP_BALBcJ_G0030667	protein coding gene	Chr6:44942580-44974638 (+)
C3H/HeJ	MGP_C3HHeJ_G0030380	protein coding gene	Chr6:46166642-46199353 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031122	protein coding gene	Chr6:47759874-47796675 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028328	protein coding gene	Chr6:42304020-42335099 (+)
CAST/EiJ	MGP_CASTEiJ_G0029784	protein coding gene	Chr6:45895487-45928142 (+)
CBA/J	MGP_CBAJ_G0030355	protein coding gene	Chr6:49782677-49819191 (+)
DBA/2J	MGP_DBA2J_G0030504	protein coding gene	Chr6:44535791-44566813 (+)
FVB/NJ	MGP_FVBNJ_G0030456	protein coding gene	Chr6:44170274-44201840 (+)
LP/J	MGP_LPJ_G0030588	protein coding gene	Chr6:46642495-46675731 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030490	protein coding gene	Chr6:52662091-52695778 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031151	protein coding gene	Chr6:46053622-46089873 (+)
PWK/PhJ	MGP_PWKPhJ_G0029496	protein coding gene	Chr6:44054692-44085338 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029332	protein coding gene	Chr6:45475698-45508500 (+)
WSB/EiJ	MGP_WSBEiJ_G0029860	protein coding gene	Chr6:46053982-46086232 (+)

Human Ortholog

ZNF398, zinc finger protein 398

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZNF398, zinc finger protein 398
Synonyms

P51, P71, ZER6
Links

HGNC:18373

NCBI Gene ID: 57541

neXtProt AC: NX_Q8TD17

UniProt: Q8TD17
Chr Location

7q36.1; chr7:149126408-149183042 (+) GRCh38

MGI Vertebrate Homology

Zfp398 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: ZNF398
Gene Tree

Zfp398

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

3
Gene trapped

1
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

31 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

4
GO References

1

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

798
Tissues

71
cDNA Data

15
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

55
RefSeq

8
UniProt

7
CCDS

CCDS20099.1, CCDS39476.1

Ensembl

ENSMUSG00000062519 (Evidence)
NCBI Gene

272347

			Length	Strain/Species	Flank
genomic	ENSMUSG00000062519	Ensembl Gene Model \| MGI Sequence Detail	37877	C57BL/6J	± kb
transcript	ENSMUST00000079881	Ensembl \| MGI Sequence Detail	2906	Not Applicable
polypeptide	ENSMUSP00000078806	Ensembl \| MGI Sequence Detail	643	Not Applicable

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UniProt

7 Sequences
InterPro Domains

IPR003655 Ancestral KRAB domain

IPR036051 KRAB domain superfamily

IPR001909 Krueppel-associated box

IPR050169 Krueppel C2H2-type zinc-finger

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type

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All nucleic 17

cDNA 15

Primer pair 2

Microarray probesets 3

Summaries

All 30

Developmental Gene Expression 4

Gene Ontology 1

Phenotypes 9
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Zfp398:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr56101	Chr6:47812584-47812659 (+)	27 bp
Tssr56102	Chr6:47812662-47812673 (+)	73 bp
Tssr56103	Chr6:47812683-47812711 (+)	102 bp
Tssr56104	Chr6:47812720-47812731 (+)	131 bp
Tssr56105	Chr6:47812732-47812758 (+)	150 bp
Tssr56106	Chr6:47846916-47846919 (+)	34,323 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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