Insc MGI Mouse Gene Detail - MGI:1917942 - INSC spindle orientation adaptor protein

Symbol

Insc
Name

INSC spindle orientation adaptor protein
Synonyms

3830422K02Rik, Inscuteable

Feature Type

protein coding gene
IDs

MGI:1917942
NCBI Gene: 233752
Alliance

gene page
Transcription Start Sites

17 TSS

Sequence Map

Chr7:114342931-114449615 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 60.23 cM
Mapping Data

1 experiment

SNPs within 2kb

3307 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1917942	protein coding gene	Chr7:114342929-114449618 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032886	protein coding gene	Chr7:118427913-118537857 (+)
A/J	MGP_AJ_G0032869	protein coding gene	Chr7:115451915-115560215 (+)
AKR/J	MGP_AKRJ_G0032801	protein coding gene	Chr7:118369166-118479830 (+)
BALB/cJ	MGP_BALBcJ_G0032874	protein coding gene	Chr7:115157038-115264806 (+)
C3H/HeJ	MGP_C3HHeJ_G0032584	protein coding gene	Chr7:118334854-118443742 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033380	protein coding gene	Chr7:123181931-123292784 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030352	protein coding gene	Chr7:116968683-117079367 (+)
CAST/EiJ	MGP_CASTEiJ_G0031912	protein coding gene	Chr7:109983586-110108219 (+)
CBA/J	MGP_CBAJ_G0032557	protein coding gene	Chr7:127298291-127411129 (+)
DBA/2J	MGP_DBA2J_G0032709	protein coding gene	Chr7:113499174-113605816 (+)
FVB/NJ	MGP_FVBNJ_G0032662	protein coding gene	Chr7:113365534-113472325 (+)
LP/J	MGP_LPJ_G0032803	protein coding gene	Chr7:119928841-120036948 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032694	protein coding gene	Chr7:128900929-129012622 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033400	protein coding gene	Chr7:117359509-117466646 (+)
PWK/PhJ	MGP_PWKPhJ_G0031620	protein coding gene	Chr7:106377268-106521673 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031467	protein coding gene	Chr7:104090624-104222207 (+)
WSB/EiJ	MGP_WSBEiJ_G0032025	protein coding gene	Chr7:118223624-118333633 (+)

Human Ortholog

INSC, INSC spindle orientation adaptor protein

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

INSC, INSC spindle orientation adaptor protein
Links

HGNC:33116

NCBI Gene ID: 387755

neXtProt AC: NX_Q1MX18

UniProt: Q1MX18
Chr Location

11p15.2; chr11:15111416-15269676 (+) GRCh38

MGI Vertebrate Homology

Insc stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: INSC
Gene Tree

Insc

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Phenotype Summary

20 phenotypes from 4 alleles in 2 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Endonuclease-mediated

2
Gene trapped

1
Radiation induced

1
Targeted

9
Genomic Mutations

1 involving Insc
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous inactivation of this gene leads to abnormal cochlear hair cell morphology.

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All GO Annotations

19
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

728
Tissues

20
cDNA Data

12
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

82
RefSeq

18
UniProt

5
CCDS

CCDS40095.2

Ensembl

ENSMUSG00000048782 (Evidence)
NCBI Gene

233752

			Length	Strain/Species	Flank
genomic	233752	NCBI Gene Model \| MGI Sequence Detail	106685	C57BL/6J	± kb
transcript	NR_175961	RefSeq \| MGI Sequence Detail	2390	C57BL/6
polypeptide	Q3HNM7	UniProt \| EBI \| MGI Sequence Detail	579	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000009055 protein inscuteable

(term hierarchy)
PDB

3RO3
InterPro Domains

IPR000225 Armadillo

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR039921 Inscuteable

IPR045789 Protein inscuteable homologue, C-terminal domain

IPR031938 Protein inscuteable homologue, LGN-binding domain

IPR038205 Protein inscuteable homologue, LGN-binding domain superfamily

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All nucleic 13

cDNA 12

Primer pair 1

Microarray probesets 2

Summaries

All 50

Developmental Gene Expression 9

Gene Ontology 6

Phenotypes 16
Earliest

J:61682 Hagiwara N, et al., Sox6 is a candidate gene for p100H myopathy, heart block, and sudden neonatal death. Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4180-5
Latest

J:308321 Lau EO, et al., DIAPH3 deficiency links microtubules to mitotic errors, defective neurogenesis, and brain dysfunction. Elife. 2021 Apr 26;10:e61974

TSS for Insc:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr68664	Chr7:114342950-114342968 (+)	28 bp
Tssr68665	Chr7:114344761-114344771 (+)	1,835 bp
Tssr68666	Chr7:114344909-114344918 (+)	1,983 bp
Tssr68667	Chr7:114344920-114344953 (+)	2,006 bp
Tssr68668	Chr7:114345142-114345166 (+)	2,223 bp
Tssr68669	Chr7:114345174-114345185 (+)	2,249 bp
Tssr68670	Chr7:114352933-114352948 (+)	10,010 bp
Tssr68671	Chr7:114352994-114352999 (+)	10,066 bp
Tssr68672	Chr7:114353015-114353028 (+)	10,091 bp
Tssr68673	Chr7:114353030-114353063 (+)	10,116 bp
Tssr68674	Chr7:114353067-114353072 (+)	10,139 bp
Tssr68675	Chr7:114367987-114367998 (+)	25,062 bp
Tssr68676	Chr7:114368002-114368016 (+)	25,078 bp
Tssr68677	Chr7:114368019-114368033 (+)	25,095 bp
Tssr68678	Chr7:114368116-114368126 (+)	25,190 bp
Tssr68679	Chr7:114445539-114445558 (+)	102,618 bp
Tssr68680	Chr7:114445560-114445573 (+)	102,636 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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