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Ubr5 Gene Detail
Summary
  • Symbol
    Ubr5
  • Name
    ubiquitin protein ligase E3 component n-recognin 5
  • Synonyms
    4432411E13Rik, Edd, Edd1, mKIAA0896
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918040
    NCBI Gene: 70790
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:37967572-38079098 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 15.10 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2440 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918040
 protein coding gene Chr15:37966421-38084103 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021805
 protein coding gene Chr15:36453450-36569006 (-)
A/J MGP_AJ_G0021765
 protein coding gene Chr15:35048650-35159988 (-)
AKR/J MGP_AKRJ_G0021745
 protein coding gene Chr15:36076864-36193907 (-)
BALB/cJ MGP_BALBcJ_G0021772
 protein coding gene Chr15:35093010-35204163 (-)
C3H/HeJ MGP_C3HHeJ_G0021546
 protein coding gene Chr15:36027572-36140644 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022211
 protein coding gene Chr15:37872437-37987538 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019748
 protein coding gene Chr15:32826885-32942388 (-)
CAST/EiJ MGP_CASTEiJ_G0021063
 protein coding gene Chr15:36423828-36541814 (-)
CBA/J MGP_CBAJ_G0021515
 protein coding gene Chr15:39078470-39194910 (-)
DBA/2J MGP_DBA2J_G0021639
 protein coding gene Chr15:34890741-35002323 (-)
FVB/NJ MGP_FVBNJ_G0021617
 protein coding gene Chr15:34291508-34404097 (-)
LP/J MGP_LPJ_G0021709
 protein coding gene Chr15:36312416-36430442 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021641
 protein coding gene Chr15:42107603-42224579 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022234
 protein coding gene Chr15:36224715-36337002 (-)
PWK/PhJ MGP_PWKPhJ_G0020807
 protein coding gene Chr15:34923501-35037819 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020645
 protein coding gene Chr15:35905868-36017626 (-)
WSB/EiJ MGP_WSBEiJ_G0021118
 protein coding gene Chr15:36168018-36286211 (-)



Homology
more
  • Human Ortholog
    UBR5, ubiquitin protein ligase E3 component n-recognin 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UBR5, ubiquitin protein ligase E3 component n-recognin 5
  • Synonyms
    DD5, EDD, EDD1, HYD
  • Links
    NCBI Gene ID: 51366
    neXtProt AC: NX_O95071
    UniProt: O95071

  • Chr Location
    8q22.3; chr8:102252273-102412759 (-)  GRCh38
Human Diseases
more
  • Diseases
    6 with human UBR5 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 3 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality during organogenesis, impaired growth of the allantois, failure or impairment of chorioallantoic fusion, impaired angiogenesis in the yolk sac and allantois, decreased cell proliferation, and increased apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    55
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    840
  • Tissues
    21
  • cDNA Data
    455
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037487 Ensembl Gene Model | MGI Sequence Detail 111527 C57BL/6J ±  kb
    transcript ENSMUST00000226414 Ensembl | MGI Sequence Detail 8397 Not Applicable  
    polypeptide ENSMUSP00000154293 Ensembl | MGI Sequence Detail 2798 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000017016 E3 ubiquitin-protein ligase UBR5
      (term hierarchy)
    • EC
      2.3.2.26
    • InterPro Domains
      IPR024725 E3 ubiquitin-protein ligase UBR5, ubiquitin-associated domain
      IPR047503 E3 ubiquitin-protein ligase UBR5, UBR-box
      IPR000569 HECT domain
      IPR035983 HECT, E3 ligase catalytic domain
      IPR036053 PABC (PABP) domain
      IPR002004 Polyadenylate-binding protein/Hyperplastic disc protein
      IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
      IPR003126 Zinc finger, UBR-type
    • GlyGen
      Q80TP3 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 455
      cDNA 455

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2146233, MGI:2146275
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 3
      Gene Ontology 12
      Phenotypes 21
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:307316 Mellis D, et al., Ubiquitin-protein ligase Ubr5 cooperates with hedgehog signalling to promote skeletal tissue homeostasis. PLoS Genet. 2021 Apr;17(4):e1009275
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory