Krt25 MGI Mouse Gene Detail - MGI:1918060

Symbol

Krt25
Name

keratin 25
Synonyms

4631426H08Rik, mIRSa1

Feature Type

protein coding gene
IDs

MGI:1918060
NCBI Gene: 70810
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr11:99206342-99213777 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 62.92 cM
Mapping Data

1 experiment

SNPs within 2kb

391 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918060	protein coding gene	Chr11:99206342-99213777 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019087	protein coding gene	Chr11:101971688-101980471 (-)
A/J	MGP_AJ_G0019055	protein coding gene	Chr11:97680376-97687815 (-)
AKR/J	MGP_AKRJ_G0019025	protein coding gene	Chr11:100711817-100720492 (-)
BALB/cJ	MGP_BALBcJ_G0019029	protein coding gene	Chr11:98184635-98192061 (-)
C3H/HeJ	MGP_C3HHeJ_G0018842	protein coding gene	Chr11:100867090-100874516 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019480	protein coding gene	Chr11:105106160-105114843 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017112	protein coding gene	Chr11:95245207-95252711 (-)
CAST/EiJ	MGP_CASTEiJ_G0018397	protein coding gene	Chr11:101853589-101861700 (-)
CBA/J	MGP_CBAJ_G0018813	protein coding gene	Chr11:109495567-109503010 (-)
DBA/2J	MGP_DBA2J_G0018921	protein coding gene	Chr11:97243385-97251412 (-)
FVB/NJ	MGP_FVBNJ_G0018910	protein coding gene	Chr11:96758579-96766002 (-)
LP/J	MGP_LPJ_G0018991	protein coding gene	Chr11:102441201-102449415 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018937	protein coding gene	Chr11:109164458-109171857 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019520	protein coding gene	Chr11:101070221-101079048 (-)
PWK/PhJ	MGP_PWKPhJ_G0018168	protein coding gene	Chr11:98320838-98328482 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017956	protein coding gene	Chr11:100832474-100839921 (-)
WSB/EiJ	MGP_WSBEiJ_G0018445	protein coding gene	Chr11:101044779-101052217 (-)

Human Ortholog

KRT25, keratin 25

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KRT25, keratin 25
Synonyms

ARWH3, KRT24IRS1, KRT25A
Links

HGNC:30839

NCBI Gene ID: 147183

neXtProt AC: NX_Q7Z3Z0

UniProt: Q7Z3Z0
Chr Location

17q21.2; chr17:40748021-40755542 (-) GRCh38

MGI Vertebrate Homology

Krt25 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: KRT25
Gene Tree

Krt25

Diseases

1 with human KRT25 associations

				Human Disease	Mouse Models
				autosomal recessive woolly hair 3 IDs autosomal recessive woolly hair 3 DOID:0111574 OMIM:616760

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

14 phenotypes from 5 alleles in 6 genetic backgrounds
1 images
24 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (ENU)

3
Endonuclease-mediated

2
Spontaneous

1
Targeted

3
Genomic Mutations

2 involving Krt25
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mutations in this gene have a defect in hair formation resulting in a wavy coat and curly vibrissae. Some alleles may compromise normal growth.

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All GO Annotations

16
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

729
Tissues

3
cDNA Data

123
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

30
RefSeq

2
UniProt

1
CCDS

CCDS25377.1

Ensembl

ENSMUSG00000035831 (Evidence)
NCBI Gene

70810

			Length	Strain/Species	Flank
genomic	70810	NCBI Gene Model \| MGI Sequence Detail	7436	C57BL/6J	± kb
transcript	NM_133730	RefSeq \| MGI Sequence Detail	2005	C57BL/6
polypeptide	Q8VCW2	UniProt \| EBI \| MGI Sequence Detail	446	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000009464 keratin, type I cytoskeletal 25

(term hierarchy)
InterPro Domains

IPR039008 Intermediate filament, rod domain

IPR002957 Keratin, type I

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All nucleic 123

cDNA 123

Microarray probesets 3

Summaries

All 51

Developmental Gene Expression 2

Gene Ontology 8

Phenotypes 24
Earliest

J:15328 Crew FAE, et al., Rex: a dominant autosomal monogenic coat texture character in the mouse. J Genet. 1939;38(1-2):341-44
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Krt25:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr110646	Chr11:99213769-99213783 (-)	1 bp
Tssr110645	Chr11:99212027-99212042 (-)	1,742 bp
Tssr110644	Chr11:99209412-99209434 (-)	4,354 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24