Trak2 MGI Mouse Gene Detail - MGI:1918077 - trafficking protein, kinesin binding 2

Symbol

Trak2
Name

trafficking protein, kinesin binding 2
Synonyms

2900022D04Rik, 4733401O11Rik, Als2cr3, CALS-C, GRIF-1, GRIF1, mKIAA0549, OIP98

Feature Type

protein coding gene
IDs

MGI:1918077
NCBI Gene: 70827
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr1:58939608-59012589 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 29.20 cM
Mapping Data

2 experiments

SNPs within 2kb

1697 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918077	protein coding gene	Chr1:58939608-59013509 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016059	protein coding gene	Chr1:58847269-58915926 (-)
A/J	MGP_AJ_G0016042	protein coding gene	Chr1:56790519-56860402 (-)
AKR/J	MGP_AKRJ_G0015998	protein coding gene	Chr1:58389153-58460463 (-)
BALB/cJ	MGP_BALBcJ_G0015997	protein coding gene	Chr1:56844222-56910844 (-)
C3H/HeJ	MGP_C3HHeJ_G0015829	protein coding gene	Chr1:58642221-58709088 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0016450	protein coding gene	Chr1:61174040-61241634 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014171	protein coding gene	Chr1:52630861-52695445 (-)
CAST/EiJ	MGP_CASTEiJ_G0015411	protein coding gene	Chr1:57777610-57844539 (-)
CBA/J	MGP_CBAJ_G0015801	protein coding gene	Chr1:63072558-63152714 (-)
DBA/2J	MGP_DBA2J_G0015902	protein coding gene	Chr1:56223396-56292376 (-)
FVB/NJ	MGP_FVBNJ_G0015904	protein coding gene	Chr1:55533843-55601871 (-)
LP/J	MGP_LPJ_G0015974	protein coding gene	Chr1:59735234-59799465 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015924	protein coding gene	Chr1:66034116-66100255 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016497	protein coding gene	Chr1:58296306-58368827 (-)
PWK/PhJ	MGP_PWKPhJ_G0015198	protein coding gene	Chr1:55566677-55633100 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0014978	protein coding gene	Chr1:57824404-57892464 (-)
WSB/EiJ	MGP_WSBEiJ_G0015474	protein coding gene	Chr1:58000558-58067184 (-)

Human Ortholog

TRAK2, trafficking kinesin protein 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TRAK2, trafficking kinesin protein 2
Synonyms

ALS2CR3, CALS-C, GRIF-1, GRIF1, MILT2, OIP98
Links

HGNC:13206

NCBI Gene ID: 66008

neXtProt AC: NX_O60296

UniProt: O60296
Chr Location

2q33.1; chr2:201377207-201451500 (-) GRCh38

MGI Vertebrate Homology

Trak2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TRAK2
Gene Tree

Trak2

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

107
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

101
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Trak2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

40 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

33
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

789
Tissues

40
cDNA Data

114
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase trak2

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All Sequences

77
RefSeq

28
UniProt

6
CCDS

CCDS14980.1

Ensembl

ENSMUSG00000026028 (Evidence)
NCBI Gene

70827

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026028	Ensembl Gene Model \| MGI Sequence Detail	72982	C57BL/6J	± kb
transcript	ENSMUST00000027186	Ensembl \| MGI Sequence Detail	6189	Not Applicable
polypeptide	ENSMUSP00000027186	Ensembl \| MGI Sequence Detail	913	Not Applicable

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UniProt

6 Sequences
InterPro Domains

IPR006933 HAP1, N-terminal

IPR051946 Intracellular Trafficking Regulator

IPR022154 Trafficking kinesin-binding protein, C-terminal
GlyGen

Q6P9N8 7 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (6 sites)

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All nucleic 115

cDNA 115

Microarray probesets 6

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MGI:1920129, MGI:2138275, MGI:2138542

Summaries

All 43

Developmental Gene Expression 5

Gene Ontology 3

Phenotypes 14
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Trak2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr11803	Chr1:59012635-59012645 (-)	-51 bp
Tssr11802	Chr1:59012609-59012620 (-)	-26 bp
Tssr11801	Chr1:59012580-59012599 (-)	-1 bp
Tssr11800	Chr1:59012545-59012556 (-)	38 bp
Tssr11799	Chr1:59012514-59012540 (-)	62 bp
Tssr11798	Chr1:59012494-59012513 (-)	85 bp
Tssr11797	Chr1:59012471-59012484 (-)	111 bp
Tssr11796	Chr1:59012445-59012459 (-)	137 bp
Tssr11795	Chr1:59011852-59011856 (-)	735 bp
Tssr11794	Chr1:59001716-59001720 (-)	10,871 bp
Tssr11793	Chr1:59001665-59001676 (-)	10,918 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24