Spag9 MGI Mouse Gene Detail - MGI:1918084 - sperm associated antigen 9

Symbol

Spag9
Name

sperm associated antigen 9
Synonyms

3110018C07Rik, 4733401I23Rik, 4831406C20Rik, JIP4, JLP, Mapk8ip4, syd1

Feature Type

protein coding gene
IDs

MGI:1918084
NCBI Gene: 70834
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr11:93886917-94016911 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 58.90 cM, cytoband C
Mapping Data

3 experiments

SNPs within 2kb

2767 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918084	protein coding gene	Chr11:93886794-94016919 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018949	protein coding gene	Chr11:96036460-96179823 (+)
A/J	MGP_AJ_G0018917	protein coding gene	Chr11:92224992-92351279 (+)
AKR/J	MGP_AKRJ_G0018887	protein coding gene	Chr11:95097417-95229143 (+)
BALB/cJ	MGP_BALBcJ_G0018890	protein coding gene	Chr11:92655379-92786508 (+)
C3H/HeJ	MGP_C3HHeJ_G0018704	protein coding gene	Chr11:95170039-95301136 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019342	protein coding gene	Chr11:99026861-99169954 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016973	protein coding gene	Chr11:89718926-89848002 (+)
CAST/EiJ	MGP_CASTEiJ_G0018259	protein coding gene	Chr11:95867654-96004037 (+)
CBA/J	MGP_CBAJ_G0018675	protein coding gene	Chr11:103133592-103281235 (+)
DBA/2J	MGP_DBA2J_G0018783	protein coding gene	Chr11:91795177-91926353 (+)
FVB/NJ	MGP_FVBNJ_G0018772	protein coding gene	Chr11:91208353-91336550 (+)
LP/J	MGP_LPJ_G0018853	protein coding gene	Chr11:96596340-96727849 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018799	protein coding gene	Chr11:103192879-103340648 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019382	protein coding gene	Chr11:95290711-95429717 (+)
PWK/PhJ	MGP_PWKPhJ_G0018029	protein coding gene	Chr11:92710855-92851254 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017819	protein coding gene	Chr11:94975533-95104085 (+)
WSB/EiJ	MGP_WSBEiJ_G0018308	protein coding gene	Chr11:95171563-95312001 (+)

Human Ortholog

SPAG9, sperm associated antigen 9

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SPAG9, sperm associated antigen 9
Synonyms

CT89, HLC4, HLC-6, HLC6, JIP-4, JIP4, JLP, PHET, PIG6
Links

HGNC:14524

NCBI Gene ID: 9043

neXtProt AC: NX_O60271

UniProt: O60271
Chr Location

17q21.33; chr17:50962174-51120868 (-) GRCh38

MGI Vertebrate Homology

Spag9 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SPAG9
Gene Tree

Spag9

Diseases

2 with human SPAG9 associations

				Human Disease	Mouse Models
				hepatocellular carcinoma IDs hepatocellular carcinoma DOID:684 DOID:5005 EFO:0000182 ICD10CM:C22.0 MESH:D006528 NCI:C3099 OMIM:114550 ORDO:88673 UMLS_CUI:C2239176
				liver cirrhosis IDs liver cirrhosis DOID:5082 EFO:0001422 ICD10CM:K74.60 MESH:D008103 NCI:C2951 UMLS_CUI:C0023890

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

less

Phenotype Summary

7 phenotypes from 2 alleles in 2 genetic backgrounds
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (ENU)

1
Endonuclease-mediated

3
Gene trapped

2
Targeted

6
Genomic Mutations

3 involving Spag9
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

77 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Male mice homozygous for a null mutation display reduced fertility with oligoasthenozoospermia.

less

All GO Annotations

48
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

820
Tissues

40
cDNA Data

27
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase spag9

less

All Sequences

131
RefSeq

44
UniProt

11
CCDS

CCDS25248.1, CCDS25249.1, CCDS36282.1, CCDS56797.1

Ensembl

ENSMUSG00000020859 (Evidence)
NCBI Gene

70834

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020859	Ensembl Gene Model \| MGI Sequence Detail	129995	C57BL/6J	± kb
transcript	ENSMUST00000041956	Ensembl \| MGI Sequence Detail	7340	Not Applicable
polypeptide	ENSMUSP00000042271	Ensembl \| MGI Sequence Detail	1307	Not Applicable

less

UniProt

11 Sequences
Protein Ontology

PR:000015463 C-Jun-amino-terminal kinase-interacting protein 4

(term hierarchy)
InterPro Domains

IPR039911 JNK-interacting protein 3/4

IPR032486 JNK-interacting protein, leucine zipper II

IPR034743 RH1 domain

IPR034744 RH2 domain

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily
GlyGen

Q58A65 1 site, 1 O-linked glycan (1 site)

less

All nucleic 30

cDNA 28

Primer pair 1

Other 1

Microarray probesets 5

less

MGI:1920413, MGI:1924388, MGI:2144568

Summaries

All 85

Developmental Gene Expression 6

Diseases 1

Gene Ontology 16

Phenotypes 22
Earliest

J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
Latest

J:354054 Tian M, et al., JLP/Foxk1/N-cadherin axis fosters a partial epithelial-mesenchymal transition state in epithelial tubular cells. iScience. 2023 Apr 21;26(4):106396

TSS for Spag9:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr104159	Chr11:93886186-93886210 (+)	-719 bp
Tssr104160	Chr11:93886226-93886240 (+)	-684 bp
Tssr104161	Chr11:93886883-93886892 (+)	-29 bp
Tssr104162	Chr11:93886908-93886925 (+)	0 bp
Tssr104163	Chr11:93934926-93934931 (+)	48,012 bp
Tssr104164	Chr11:93934937-93934947 (+)	48,025 bp
Tssr104165	Chr11:93934950-93934962 (+)	48,039 bp
Tssr104166	Chr11:93934968-93934982 (+)	48,058 bp
Tssr104167	Chr11:93935020-93935064 (+)	48,125 bp
Tssr104168	Chr11:93935067-93935099 (+)	48,166 bp
Tssr104169	Chr11:93935115-93935122 (+)	48,202 bp
Tssr104170	Chr11:93935150-93935155 (+)	48,236 bp
Tssr104171	Chr11:93935157-93935168 (+)	48,246 bp
Tssr104172	Chr11:93967218-93967247 (+)	80,316 bp
Tssr104173	Chr11:93972154-93972200 (+)	85,260 bp
Tssr104174	Chr11:94002449-94002458 (+)	115,537 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24