Cnbd2 MGI Mouse Gene Detail - MGI:1918123 - cyclic nucleotide binding domain containing 2

Symbol

Cnbd2
Name

cyclic nucleotide binding domain containing 2
Synonyms

4921517L17Rik, 5430421B09Rik

Feature Type

protein coding gene
IDs

MGI:1918123
NCBI Gene: 70873
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr2:156154219-156217558 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 77.39 cM, cytoband H2
Mapping Data

2 experiments

SNPs within 2kb

1788 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1918123	protein coding gene	Chr2:156153866-156217558 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026763	protein coding gene	Chr2:161190787-161254914 (+)
A/J	MGP_AJ_G0026729	protein coding gene	Chr2:154793203-154851339 (+)
AKR/J	MGP_AKRJ_G0026700	protein coding gene	Chr2:159280883-159346828 (+)
BALB/cJ	MGP_BALBcJ_G0026738	protein coding gene	Chr2:155078193-155134021 (+)
C3H/HeJ	MGP_C3HHeJ_G0026481	protein coding gene	Chr2:159632561-159690092 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027187	protein coding gene	Chr2:165915230-165978880 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024557	protein coding gene	Chr2:148261487-148319802 (+)
CAST/EiJ	MGP_CASTEiJ_G0025942	protein coding gene	Chr2:159965337-160025149 (+)
CBA/J	MGP_CBAJ_G0026458	protein coding gene	Chr2:171948195-172013840 (+)
DBA/2J	MGP_DBA2J_G0026595	protein coding gene	Chr2:153960059-154019489 (+)
FVB/NJ	MGP_FVBNJ_G0026562	protein coding gene	Chr2:152331120-152392046 (+)
LP/J	MGP_LPJ_G0026700	protein coding gene	Chr2:161316163-161379355 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026583	protein coding gene	Chr2:175885521-175948242 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027243	protein coding gene	Chr2:159153758-159214050 (+)
PWK/PhJ	MGP_PWKPhJ_G0025676	protein coding gene	Chr2:153460651-153517916 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025479	protein coding gene	Chr2:158096347-158156579 (+)
WSB/EiJ	MGP_WSBEiJ_G0026012	protein coding gene	Chr2:160043038-160104877 (+)

Human Ortholog

CNBD2, cyclic nucleotide binding domain containing 2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CNBD2, cyclic nucleotide binding domain containing 2
Synonyms

C20orf152, CNMPD1
Links

HGNC:16145

NCBI Gene ID: 140894

neXtProt AC: NX_Q96M20

UniProt: Q96M20
Chr Location

20q11.23; chr20:35954386-36030700 (+) GRCh38

MGI Vertebrate Homology

Cnbd2 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: CNBD2
Gene Tree

Cnbd2

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Phenotype Summary

12 phenotypes from 1 allele in 1 genetic background
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

1
Gene trapped

2
Targeted

3
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

34 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit reduced male fertility associated with impaired spermiogenesis and development of flagellum bending.

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All GO Annotations

5
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

19
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cnbd2

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All Sequences

65
RefSeq

16
UniProt

7
CCDS

CCDS50778.1

Ensembl

ENSMUSG00000038085 (Evidence)
NCBI Gene

70873

			Length	Strain/Species	Flank
genomic	ENSMUSG00000038085	Ensembl Gene Model \| MGI Sequence Detail	63340	C57BL/6J	± kb
transcript	ENSMUST00000037096	Ensembl \| MGI Sequence Detail	2277	Not Applicable
polypeptide	ENSMUSP00000041268	Ensembl \| MGI Sequence Detail	673	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000060021 cyclic nucleotide-binding domain-containing protein 2

(term hierarchy)
InterPro Domains

IPR018488 Cyclic nucleotide-binding, conserved site

IPR000595 Cyclic nucleotide-binding domain

IPR043533 Cyclic nucleotide-binding domain-containing protein 1/2

IPR018490 Cyclic nucleotide-binding domain superfamily

IPR014710 RmlC-like jelly roll fold

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All nucleic 19

cDNA 19

Microarray probesets 4

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MGI:1918593

Summaries

All 29

Developmental Gene Expression 1

Gene Ontology 2

Phenotypes 5
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:207897 Krahling AM, et al., CRIS-a novel cAMP-binding protein controlling spermiogenesis and the development of flagellar bending. PLoS Genet. 2013 Dec;9(12):e1003960

TSS for Cnbd2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr21148	Chr2:156153673-156153686 (+)	-539 bp
Tssr21149	Chr2:156154339-156154346 (+)	124 bp
Tssr21150	Chr2:156154348-156154401 (+)	156 bp
Tssr21151	Chr2:156154509-156154545 (+)	308 bp
Tssr716	Chr2:156211155-156211159 (+)	56,938 bp
Tssr21152	Chr2:156213173-156213191 (+)	58,963 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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