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Nt5c1b Gene Detail
Summary
  • Symbol
    Nt5c1b
  • Name
    5'-nucleotidase, cytosolic IB
  • Synonyms
    4921514H13Rik, CN-IB
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918131
    NCBI Gene: 70881
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:10419973-10440175 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 12, 5.27 cM, cytoband A2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    536 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1918131
protein coding gene Chr12:10419971-10440175 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019594
protein coding gene Chr12:7533639-7562123 (+)
A/J MGP_AJ_G0019561
protein coding gene Chr12:7284833-7305549 (+)
AKR/J MGP_AKRJ_G0019531
protein coding gene Chr12:7755319-7775351 (+)
BALB/cJ MGP_BALBcJ_G0019536
protein coding gene Chr12:7453380-7476506 (+)
C3H/HeJ MGP_C3HHeJ_G0019342
protein coding gene Chr12:7566526-7587632 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019985
protein coding gene Chr12:7793942-7816287 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017610
protein coding gene Chr12:7044983-7064827 (+)
CAST/EiJ MGP_CASTEiJ_G0018898
protein coding gene Chr12:7576300-7600342 (+)
CBA/J MGP_CBAJ_G0019313
protein coding gene Chr12:8400426-8423313 (+)
DBA/2J MGP_DBA2J_G0019426
protein coding gene Chr12:7233374-7263415 (+)
FVB/NJ MGP_FVBNJ_G0019417
protein coding gene Chr12:7175117-7195015 (+)
LP/J MGP_LPJ_G0019497
protein coding gene Chr12:7590398-7610371 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019450
protein coding gene Chr12:8179274-8202020 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020024
protein coding gene Chr12:7464417-7486078 (+)
PWK/PhJ MGP_PWKPhJ_G0018664
protein coding gene Chr12:7337235-7358205 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018454
protein coding gene Chr12:7560687-7580491 (+)
WSB/EiJ MGP_WSBEiJ_G0018949
protein coding gene Chr12:7521437-7547521 (+)



Homology
more
  • Human Ortholog
    NT5C1B, 5'-nucleotidase, cytosolic IB
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NT5C1B, 5'-nucleotidase, cytosolic IB
  • Synonyms
    AIRP, CN1B, CN-IB
  • Links
    NCBI Gene ID: 93034
    neXtProt AC: NX_Q96P26
    UniProt: Q96P26

  • Chr Location
    2p24.2; chr2:18562871-18589572 (-)  GRCh38

  • Human Ortholog
    NT5C1B-RDH14, NT5C1B-RDH14 readthrough
  • Synonyms
    AIRP, cN1B, cN-IB, NT5C1B
  • Links
    NCBI Gene ID: 100526794
    neXtProt AC: NX_Q96P26

  • Chr Location
    2p24.2; chr2:18554723-18589569 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice homozygous for a null allele exhibit normal fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020622 Ensembl Gene Model | MGI Sequence Detail 20203 C57BL/6J ±  kb
    transcript ENSMUST00000219826 Ensembl | MGI Sequence Detail 2023 Not Applicable  
    polypeptide ENSMUSP00000151401 Ensembl | MGI Sequence Detail 631 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 17

      Microarray probesets 4
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 8
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:348447 Nguyen TTT, et al., Gene-deficient mouse model established by CRISPR/Cas9 system reveals 15 reproductive organ-enriched genes dispensable for male fertility. Frontiers in Cell and Developmental Biology. 2024;12

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    12/10/2024
    MGI 6.24
    The Jackson Laboratory